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. 1988 Aug;51(8):1022–1031. doi: 10.1136/jnnp.51.8.1022

Limb pain in migraine and cluster headache.

R J Guiloff 1, M Fruns 1
PMCID: PMC1033109  PMID: 3216204

Abstract

Upper limb pain occurred in close temporal association with attacks of migraine, cluster headache and cluster-migraine in 22 cases. Seven had also lower limb pain. Limb pain was usually ipsilateral to the headache but could alternate sides and behaved like other accepted migraine accompaniments. It was always ipsilateral to the associated paraesthesiae/numbness (9 cases) and weakness (6 cases). The distribution and restricted localisations of limb pain were similar to those of the sensory symptoms and could not be accounted for by primary dysfunction of the peripheral or autonomic nervous systems. A central origin for limb pain is postulated. A temporary dysfunction in the somatosensory cortex, and/or its thalamic connections, during migraine or cluster headache attacks, might mediate such pain in a number of patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersson S. A., Rydenhag B. Cortical nociceptive systems. Philos Trans R Soc Lond B Biol Sci. 1985 Feb 19;308(1136):347–359. doi: 10.1098/rstb.1985.0035. [DOI] [PubMed] [Google Scholar]
  2. BIEMOND A. The conduction of pain above the level of the thalamus opticus. AMA Arch Neurol Psychiatry. 1956 Mar;75(3):231–244. doi: 10.1001/archneurpsyc.1956.02330210011001. [DOI] [PubMed] [Google Scholar]
  3. BRADSHAW P., PARSONS M. HEMIPLEGIC MIGRAINE, A CLINICAL STUDY. Q J Med. 1965 Jan;34:65–85. [PubMed] [Google Scholar]
  4. Basser L. S. The relation of migraine and epilepsy. Brain. 1969;92(2):285–300. doi: 10.1093/brain/92.2.285. [DOI] [PubMed] [Google Scholar]
  5. Bruyn G. W., Weenink H. R. Migraine accompagnee, a critical evaluation. Headache. 1966 Apr;6(1):1–22. doi: 10.1111/j.1526-4610.1966.hed0601001.x. [DOI] [PubMed] [Google Scholar]
  6. Chatrian G. E., Canfield R. C., Knauss T. A., Eegt E. L. Cerebral responses to electrical tooth pulp stimulation in man. An objective correlate of acute experimental pain. Neurology. 1975 Aug;25(8):745–757. doi: 10.1212/wnl.25.8.745. [DOI] [PubMed] [Google Scholar]
  7. Denny-Brown D., Yanagisawa N. The function of the descending root of the fifth nerve. Brain. 1973 Dec;96(4):783–814. doi: 10.1093/brain/96.4.783. [DOI] [PubMed] [Google Scholar]
  8. ECHLIN F. Pain responses on stimulation of the lumbar sympathetic chain under local anesthesia; a case report. J Neurosurg. 1949 Nov;6(6):530–533. doi: 10.3171/jns.1949.6.6.0530. [DOI] [PubMed] [Google Scholar]
  9. Edmeads J. Headaches and head pains associated with diseases of the cervical spine. Med Clin North Am. 1978 May;62(3):533–544. doi: 10.1016/s0025-7125(16)31791-6. [DOI] [PubMed] [Google Scholar]
  10. Fields H. L., Adams J. E. Pain after cortical injury relieved by electrical stimulation of the internal capsule. Brain. 1974 Mar;97(1):169–178. doi: 10.1093/brain/97.1.169. [DOI] [PubMed] [Google Scholar]
  11. Fisher C. M. Late-life migraine accompaniments as a cause of unexplained transient ischemic attacks. Can J Neurol Sci. 1980 Feb;7(1):9–17. [PubMed] [Google Scholar]
  12. Gillmann H. Schmerzempfindung--Ursachen und Beeinflussungsmöglichkeiten. Arzneimittelforschung. 1984;34(9A):1051–1052. [PubMed] [Google Scholar]
  13. Jones E. G., Powell T. P. Connexions of the somatic sensory cortex of the rhesus monkey. I. Ipsilateral cortical connexions. Brain. 1969;92(3):477–502. doi: 10.1093/brain/92.3.477. [DOI] [PubMed] [Google Scholar]
  14. KERR F. W., OLAFSON R. A. Trigeminal and cervical volleys. Convergence on single units in the spinal gray at C-1 and C-2. Arch Neurol. 1961 Aug;5:171–178. doi: 10.1001/archneur.1961.00450140053005. [DOI] [PubMed] [Google Scholar]
  15. KUNTZ A. Afferent innervation of peripheral blood vessels through sympathetic trunks; its clinical implications. South Med J. 1951 Aug;44(8):673–678. doi: 10.1097/00007611-195108000-00001. [DOI] [PubMed] [Google Scholar]
  16. Laplante P., Saint-Hilaire J. M., Bouvier G. Headache as an epileptic manifestation. Neurology. 1983 Nov;33(11):1493–1495. doi: 10.1212/wnl.33.11.1493. [DOI] [PubMed] [Google Scholar]
  17. Leon-Sotomayor L. A. Cardiac migraine--report of twelve cases. Angiology. 1974 Mar;25(3):161–171. doi: 10.1177/000331977402500301. [DOI] [PubMed] [Google Scholar]
  18. MEHLER W. R., FEFERMAN M. E., NAUTA W. J. Ascending axon degeneration following anterolateral cordotomy. An experimental study in the monkey. Brain. 1960 Dec;83:718–750. doi: 10.1093/brain/83.4.718. [DOI] [PubMed] [Google Scholar]
  19. MONTGOMERY B. M., KING W. W., Jr Hemiplegic migraine: a case with paroxysmal shoulder-hand syndrome. Ann Intern Med. 1962 Sep;57:450–455. doi: 10.7326/0003-4819-57-3-450. [DOI] [PubMed] [Google Scholar]
  20. MOUNTCASTLE V. B., POWELL T. P. Neural mechanisms subserving cutaneous sensibility, with special reference to the role of afferent inhibition in sensory perception and discrimination. Bull Johns Hopkins Hosp. 1959 Oct;105:201–232. [PubMed] [Google Scholar]
  21. Olesen J., Larsen B., Lauritzen M. Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine. Ann Neurol. 1981 Apr;9(4):344–352. doi: 10.1002/ana.410090406. [DOI] [PubMed] [Google Scholar]
  22. Raskin N. H., Schwartz R. K. Icepick-like pain. Neurology. 1980 Feb;30(2):203–205. doi: 10.1212/wnl.30.2.203. [DOI] [PubMed] [Google Scholar]
  23. SILVER M. L. Central pain from cerebral arteriovenous aneurysm. J Neurosurg. 1957 Jan;14(1):92–96. doi: 10.3171/jns.1957.14.1.0092. [DOI] [PubMed] [Google Scholar]
  24. Sjaastad O., Dale I. A new (?) Clinical headache entity "chronic paroxysmal hemicrania" 2. Acta Neurol Scand. 1976 Aug;54(2):140–159. doi: 10.1111/j.1600-0404.1976.tb04788.x. [DOI] [PubMed] [Google Scholar]
  25. Sjaastad O., Dale I. Evidence for a new (?), treatable headache entity. Headache. 1974 Jul;14(2):105–108. doi: 10.1111/j.1526-4610.1974.hed1402105.x. [DOI] [PubMed] [Google Scholar]
  26. Sjaastad O., Saunte C., Hovdahl H., Breivik H., Grønbaek E. "Cervicogenic" headache. An hypothesis. Cephalalgia. 1983 Dec;3(4):249–256. doi: 10.1046/j.1468-2982.1983.0304249.x. [DOI] [PubMed] [Google Scholar]
  27. TALAIRACH J., TOURNOUX P., BANCAUD J. [Parietal surgery of pain]. Acta Neurochir (Wien) 1960 May 25;8:153–250. doi: 10.1007/BF01406275. [DOI] [PubMed] [Google Scholar]
  28. Whitsel B. L., Petrucelli L. M., Werner G. Symmetry and connectivity in the map of the body surface in somatosensory area II of primates. J Neurophysiol. 1969 Mar;32(2):170–183. doi: 10.1152/jn.1969.32.2.170. [DOI] [PubMed] [Google Scholar]
  29. Wilkinson H. A. Epileptic pain. An uncommon manifestation with localizing value. Neurology. 1973 May;23(5):518–520. doi: 10.1212/wnl.23.5.518. [DOI] [PubMed] [Google Scholar]
  30. Woolsey C. N., Erickson T. C., Gilson W. E. Localization in somatic sensory and motor areas of human cerebral cortex as determined by direct recording of evoked potentials and electrical stimulation. J Neurosurg. 1979 Oct;51(4):476–506. doi: 10.3171/jns.1979.51.4.0476. [DOI] [PubMed] [Google Scholar]
  31. Yaksh T. L., Hammond D. L. Peripheral and central substrates involved in the rostrad transmission of nociceptive information. Pain. 1982 May;13(1):1–85. doi: 10.1016/0304-3959(82)90067-7. [DOI] [PubMed] [Google Scholar]

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