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. 1988 Aug;51(8):1051–1057. doi: 10.1136/jnnp.51.8.1051

Effects of enzymatic blood defibrination in subcortical arteriosclerotic encephalopathy.

E B Ringelstein 1, A Mauckner 1, R Schneider 1, W Sturm 1, W Doering 1, S Wolf 1, N Maurin 1, K Willmes 1, M Schlenker 1, H Brückmann 1, et al.
PMCID: PMC1033113  PMID: 3063776

Abstract

Plasma hyperviscosity is a striking abnormality in patients suffering from subcortical arteriosclerotic encephalopathy (SAE) and is thought to perpetuate the chronic ischaemic demyelinating process of the periventricular white matter. Ancrod, a defibrinating enzyme, was given to 10 patients with SAE in an attempt to reduce plasma fibrinogen, which would thus normalise hyperviscosity. This was paralleled by a significant improvement of the initially abnormal retinal arteriovenous passage time, as well as a significant augmentation of the CO2-induced cerebral vasomotor response. This did not lead, however, to any clinical improvement with respect to performance of neuropsychological tests, recurrences of strokes during a 6 month observation period or improvement of various audiological parameters. The findings indicate that hyperviscosity in patients with SAE is merely an epiphenomenon. A potentially reversible, chronic penumbral state of the brain tissue apparently does not exist in SAE.

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Selected References

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