Abstract
Basal dendrites of hippocampal CA1 pyramidal cells in senile dementia of Alzheimer type (SDAT) were studied quantitatively by the Golgi impregnation method. The present data suggested that basal dendrites of the pyramidal cells were decreased in number in SDAT, and that the dendritic decrease was associated with a decrease in size of their cell bodies.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Buell S. J., Coleman P. D. Dendritic growth in the aged human brain and failure of growth in senile dementia. Science. 1979 Nov 16;206(4420):854–856. doi: 10.1126/science.493989. [DOI] [PubMed] [Google Scholar]
- Flood D. G., Guarnaccia M., Coleman P. D. Dendritic extent in human CA2-3 hippocampal pyramidal neurons in normal aging and senile dementia. Brain Res. 1987 Apr 14;409(1):88–96. doi: 10.1016/0006-8993(87)90744-x. [DOI] [PubMed] [Google Scholar]
- Hyman B. T., Van Hoesen G. W., Damasio A. R., Barnes C. L. Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. Science. 1984 Sep 14;225(4667):1168–1170. doi: 10.1126/science.6474172. [DOI] [PubMed] [Google Scholar]
- Probst A., Basler V., Bron B., Ulrich J. Neuritic plaques in senile dementia of Alzheimer type: a Golgi analysis in the hippocampal region. Brain Res. 1983 Jun 6;268(2):249–254. doi: 10.1016/0006-8993(83)90490-0. [DOI] [PubMed] [Google Scholar]
- SHOLL D. A. Dendritic organization in the neurons of the visual and motor cortices of the cat. J Anat. 1953 Oct;87(4):387–406. [PMC free article] [PubMed] [Google Scholar]
- Scheibel A. B., Tomiyasu U. Dendritic sprouting in Alzheimer's presenile dementia. Exp Neurol. 1978 May 15;60(1):1–8. doi: 10.1016/0014-4886(78)90164-4. [DOI] [PubMed] [Google Scholar]
- Scheibel M. E., Lindsay R. D., Tomiyasu U., Scheibel A. B. Progressive dendritic changes in aging human cortex. Exp Neurol. 1975 Jun;47(3):392–403. doi: 10.1016/0014-4886(75)90072-2. [DOI] [PubMed] [Google Scholar]
- Scheibel M. E., Lindsay R. D., Tomiyasu U., Scheibel A. B. Progressive dendritic changes in the aging human limbic system. Exp Neurol. 1976 Nov;53(2):420–430. doi: 10.1016/0014-4886(76)90082-0. [DOI] [PubMed] [Google Scholar]