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. 1988 Jun;51(6):790–795. doi: 10.1136/jnnp.51.6.790

Central motor conduction in degenerative ataxic disorders: a magnetic stimulation study.

D Claus 1, A E Harding 1, C W Hess 1, K R Mills 1, N M Murray 1, P K Thomas 1
PMCID: PMC1033149  PMID: 2841427

Abstract

Central motor conduction to small hand muscles was measured using magnetic stimulation of the motor cortex and electrical stimulation of proximal motor roots in 11 patients with Friedreich's ataxia, 10 patients with early onset cerebellar ataxia with retained tendon reflexes (EOCA) and 13 patients with late onset degenerative cerebellar disease (LOCD). Central motor conduction was abnormal in 91% with Friedreich's ataxia, 70% with EOCA and 38% with LOCD. Central motor conduction abnormalities were not specific to individual disorders but were more severe and were related to disease duration in Friedreich's ataxia and EOCA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barker A. T., Jalinous R., Freeston I. L. Non-invasive magnetic stimulation of human motor cortex. Lancet. 1985 May 11;1(8437):1106–1107. doi: 10.1016/s0140-6736(85)92413-4. [DOI] [PubMed] [Google Scholar]
  2. Caruso G., Santoro L., Perretti A., Massini R., Pelosi L., Crisci C., Ragno M., Campanella G., Filla A. Friedreich's ataxia: electrophysiologic and histologic findings in patients and relatives. Muscle Nerve. 1987 Jul-Aug;10(6):503–515. doi: 10.1002/mus.880100604. [DOI] [PubMed] [Google Scholar]
  3. Claus D., Schöcklmann H. O., Dietrich H. J. Long latency muscle responses in cerebellar diseases. Eur Arch Psychiatry Neurol Sci. 1986;235(6):355–360. doi: 10.1007/BF00381004. [DOI] [PubMed] [Google Scholar]
  4. Felix D., Wiesendanger M. Pyramidal and non-pyramidal motor cortical effects on distal forelimb muscles of monkeys. Exp Brain Res. 1971;12(1):81–91. doi: 10.1007/BF00234417. [DOI] [PubMed] [Google Scholar]
  5. Friedemann H. H., Noth J., Diener H. C., Bacher M. Long latency EMG responses in hand and leg muscles: cerebellar disorders. J Neurol Neurosurg Psychiatry. 1987 Jan;50(1):71–77. doi: 10.1136/jnnp.50.1.71. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Geoffroy G., Barbeau A., Breton G., Lemieux B., Aube M., Leger C., Bouchard J. P. Clinical description and roentgenologic evaluation of patients with Friedreich's ataxia. Can J Neurol Sci. 1976 Nov;3(4):279–286. doi: 10.1017/s0317167100025464. [DOI] [PubMed] [Google Scholar]
  7. Harding A. E. Early onset cerebellar ataxia with retained tendon reflexes: a clinical and genetic study of a disorder distinct from Friedreich's ataxia. J Neurol Neurosurg Psychiatry. 1981 Jun;44(6):503–508. doi: 10.1136/jnnp.44.6.503. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hess C. W., Mills K. R., Murray N. M. Magnetic stimulation of the human brain: facilitation of motor responses by voluntary contraction of ipsilateral and contralateral muscles with additional observations on an amputee. Neurosci Lett. 1986 Nov 11;71(2):235–240. doi: 10.1016/0304-3940(86)90565-3. [DOI] [PubMed] [Google Scholar]
  9. Hess C. W., Mills K. R., Murray N. M. Measurement of central motor conduction in multiple sclerosis by magnetic brain stimulation. Lancet. 1986 Aug 16;2(8503):355–358. doi: 10.1016/s0140-6736(86)90050-4. [DOI] [PubMed] [Google Scholar]
  10. Hess C. W., Mills K. R., Murray N. M. Responses in small hand muscles from magnetic stimulation of the human brain. J Physiol. 1987 Jul;388:397–419. doi: 10.1113/jphysiol.1987.sp016621. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hess C. W., Mills K. R., Murray N. M., Schriefer T. N. Magnetic brain stimulation: central motor conduction studies in multiple sclerosis. Ann Neurol. 1987 Dec;22(6):744–752. doi: 10.1002/ana.410220611. [DOI] [PubMed] [Google Scholar]
  12. Jones S. J., Baraitser M., Halliday A. M. Peripheral and central somatosensory nerve conduction defects in Friedreich's ataxia. J Neurol Neurosurg Psychiatry. 1980 Jun;43(6):495–503. doi: 10.1136/jnnp.43.6.495. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. McLeod J. G. An electrophysiological and pathological study of peripheral nerves in Friedreich's ataxia. J Neurol Sci. 1971 Mar;12(3):333–349. doi: 10.1016/0022-510x(71)90067-0. [DOI] [PubMed] [Google Scholar]
  14. Mills K. R., Murray N. M. Electrical stimulation over the human vertebral column: which neural elements are excited? Electroencephalogr Clin Neurophysiol. 1986 Jun;63(6):582–589. doi: 10.1016/0013-4694(86)90145-8. [DOI] [PubMed] [Google Scholar]
  15. Oppenheimer D. R. Brain lesions in Friedreich's ataxia. Can J Neurol Sci. 1979 May;6(2):173–176. doi: 10.1017/s0317167100119596. [DOI] [PubMed] [Google Scholar]
  16. Ouvrier R. A., McLeod J. G., Conchin T. E. Friedreich's ataxia. Early detection and progression of peripheral nerve abnormalities. J Neurol Sci. 1982 Aug;55(2):137–145. doi: 10.1016/0022-510x(82)90095-8. [DOI] [PubMed] [Google Scholar]
  17. Puska P., Iacono J. M., Nissinen A., Korhonen H. J., Vartianinen E., Pietinen P., Dougherty R., Leino U., Mutanen M., Moisio S. Controlled, randomised trial of the effect of dietary fat on blood pressure. Lancet. 1983 Jan 1;1(8314-5):1–5. doi: 10.1016/s0140-6736(83)91556-8. [DOI] [PubMed] [Google Scholar]
  18. Sauer M. Somatosensible Leitungsmessungen bei neurologischen Systemerkrankungen. Arch Psychiatr Nervenkr (1970) 1980;228(3):223–242. doi: 10.1007/BF00342348. [DOI] [PubMed] [Google Scholar]
  19. Thomas P. K., Walker R. W., Rudge P., Morgan-Hughes J. A., King R. H., Jacobs J. M., Mills K. R., Ormerod I. E., Murray N. M., McDonald W. I. Chronic demyelinating peripheral neuropathy associated with multifocal central nervous system demyelination. Brain. 1987 Feb;110(Pt 1):53–76. doi: 10.1093/brain/110.1.53. [DOI] [PubMed] [Google Scholar]

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