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. 1988 Jun;51(6):859–862. doi: 10.1136/jnnp.51.6.859

Dystonia in homocystinuria.

P A Kempster 1, D P Brenton 1, A N Gale 1, G M Stern 1
PMCID: PMC1033161  PMID: 3404194

Abstract

Three patients with homocystinuria due to cystathionine beta-synthase deficiency who developed progressive generalised dystonia are described. Although cerebrovascular thrombosis is usually thought to be responsible for neurological dysfunction in homocystinuric patients, neuropathological studies in one case and clinical and radiological evidence in the other two suggested that dystonia was not caused by brain infarction. Movement disorder associated with homocystinuria may result from the neurochemical changes in the basal ganglia related to the inherited defect in sulphur amino acid metabolism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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