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. 1988 Jul;51(7):909–913. doi: 10.1136/jnnp.51.7.909

Does a "moderate" alcohol intake damage the brain?

C Harper 1, J Kril 1, J Daly 1
PMCID: PMC1033192  PMID: 3204399

Abstract

A range of volumetric and neurochemical analyses were carried out on the brains of 14 "moderate" drinkers. These data were compared with previous studies from controls and alcoholics. Volumetric measurements consistently suggest a loss of cerebral tissue although the differences were not statistically significant. Changes in the lipid and water content of the white matter were noted and the significance of these changes in relation to the pathogenesis of reversible brain shrinkage caused by alcohol abuse is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cala L. A., Jones B., Mastaglia F. L., Wiley B. Brain atrophy and intellectual impairment in heavy drinkers--a clinical, psychometric and computerized tomography study. Aust N Z J Med. 1978 Apr;8(2):147–153. doi: 10.1111/j.1445-5994.1978.tb04502.x. [DOI] [PubMed] [Google Scholar]
  2. Carlen P. L., Wortzman G., Holgate R. C., Wilkinson D. A., Rankin J. C. Reversible cerebral atrophy in recently abstinent chronic alcoholics measured by computed tomography scans. Science. 1978 Jun 2;200(4345):1076–1078. doi: 10.1126/science.653357. [DOI] [PubMed] [Google Scholar]
  3. Chin J. H., Goldstein D. B. Membrane-disordering action of ethanol: variation with membrane cholesterol content and depth of the spin label probe. Mol Pharmacol. 1981 May;19(3):425–431. [PubMed] [Google Scholar]
  4. DAVISON A. N., WAJDA M. Cerebral lipids in multiple sclerosis. J Neurochem. 1962 Jul-Aug;9:427–432. doi: 10.1111/j.1471-4159.1962.tb09470.x. [DOI] [PubMed] [Google Scholar]
  5. FOLCH J., LEES M., SLOANE STANLEY G. H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957 May;226(1):497–509. [PubMed] [Google Scholar]
  6. Harper C. G., Blumbergs P. C. Brain weights in alcoholics. J Neurol Neurosurg Psychiatry. 1982 Sep;45(9):838–840. doi: 10.1136/jnnp.45.9.838. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Harper C. G., Kril J. J., Daly J. M. Brain shrinkage in alcoholics is not caused by changes in hydration: a pathological study. J Neurol Neurosurg Psychiatry. 1988 Jan;51(1):124–127. doi: 10.1136/jnnp.51.1.124. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Harper C. G., Kril J. J., Daly J. M. The specific gravity of the brains of alcoholic and control patients: a pathological study. Br J Addict. 1987 Dec;82(12):1349–1354. doi: 10.1111/j.1360-0443.1987.tb00438.x. [DOI] [PubMed] [Google Scholar]
  9. Harper C. G., Kril J. J., Holloway R. L. Brain shrinkage in chronic alcoholics: a pathological study. Br Med J (Clin Res Ed) 1985 Feb 16;290(6467):501–504. doi: 10.1136/bmj.290.6467.501. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Harper C., Kril J. Brain atrophy in chronic alcoholic patients: a quantitative pathological study. J Neurol Neurosurg Psychiatry. 1985 Mar;48(3):211–217. doi: 10.1136/jnnp.48.3.211. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Harper C., Kril J., Daly J. Are we drinking our neurones away? Br Med J (Clin Res Ed) 1987 Feb 28;294(6571):534–536. doi: 10.1136/bmj.294.6571.534. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Harper C., Kril J. Pathological changes in alcoholic brain shrinkage. Med J Aust. 1986 Jan 6;144(1):3–4. doi: 10.5694/j.1326-5377.1986.tb113618.x. [DOI] [PubMed] [Google Scholar]
  13. Harper C., Kril J., Raven D., Jones N. Intracranial cavity volumes: a new method and its potential applications. Neuropathol Appl Neurobiol. 1984 Jan-Feb;10(1):25–32. doi: 10.1111/j.1365-2990.1984.tb00337.x. [DOI] [PubMed] [Google Scholar]
  14. Hay D. A., Cummins J. E. Genetic dependence of alcohol-related disease: animal models. Aust N Z J Med. 1981 Apr;11(2):148–153. doi: 10.1111/j.1445-5994.1981.tb04222.x. [DOI] [PubMed] [Google Scholar]
  15. Lishman W. A., Jacobson R. R., Acker C. Brain damage in alcoholism: current concepts. Acta Med Scand Suppl. 1987;717:5–17. doi: 10.1111/j.0954-6820.1987.tb13037.x. [DOI] [PubMed] [Google Scholar]
  16. Marmarou A., Poll W., Shulman K., Bhagavan H. A simple gravimetric technique for measurement of cerebral edema. J Neurosurg. 1978 Oct;49(4):530–537. doi: 10.3171/jns.1978.49.4.0530. [DOI] [PubMed] [Google Scholar]
  17. O'Brien J. S., Sampson E. L. Lipid composition of the normal human brain: gray matter, white matter, and myelin. J Lipid Res. 1965 Oct;6(4):537–544. [PubMed] [Google Scholar]
  18. Paton A., Saunders J. B. ABC of alcohol. Definitions. Br Med J (Clin Res Ed) 1981 Nov 7;283(6301):1248–1250. doi: 10.1136/bmj.283.6301.1248. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Phillips S. C., Harper C. G., Kril J. A quantitative histological study of the cerebellar vermis in alcoholic patients. Brain. 1987 Apr;110(Pt 2):301–314. doi: 10.1093/brain/110.2.301. [DOI] [PubMed] [Google Scholar]
  20. Ron M. A. The alcoholic brain: CT scan and psychological findings. Psychol Med Monogr Suppl. 1983;3:1–33. doi: 10.1017/s0264180100000345. [DOI] [PubMed] [Google Scholar]
  21. Shaw D. M., Frizel D., Camps F. E., White S. Brain electrolytes in depressive and alcoholic suicides. Br J Psychiatry. 1969 Jan;115(518):69–79. doi: 10.1192/bjp.115.518.69. [DOI] [PubMed] [Google Scholar]
  22. Yates A. J., Thelmo W., Pappius H. M. Postmorten changes in the chemistry and histology of normal and edematous brains. Am J Pathol. 1975 Jun;79(3):555–564. [PMC free article] [PubMed] [Google Scholar]

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