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. 1988 Jul;51(7):929–933. doi: 10.1136/jnnp.51.7.929

Concentration-effect relationships with carbamazepine and its epoxide on psychomotor and cognitive function in epileptic patients.

R A Gillham 1, N Williams 1, K Wiedmann 1, E Butler 1, J G Larkin 1, M J Brodie 1
PMCID: PMC1033196  PMID: 3204401

Abstract

A battery of psychometric tests was administered to 85 patients with epilepsy, of whom 26 were untreated, 40 received carbamazepine monotherapy and 19 took carbamazepine with another anticonvulsant. Carbamazepine alone had little effect on performance, but carbamazepine polypharmacy produced significant impairment. Increasing concentrations of carbamazepine (four tests) and its active metabolite, carbamazepine 10,11 epoxide (seven tests), correlated with decreasing performance in the monotherapy patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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