Abstract
In order to test the regenerative capacity of atrophic axons, a constricting ligature was placed around the proximal tibial nerve of the rabbit, and the nerve crushed at the ankle one week later. Axonal atrophy with altered g ratios was subsequently confirmed in fibres distal to the site of ligature and proximal to the site of crush. In nerves with tight proximal ligatures the reinnervation of plantar muscles and the subsequent recovery of distal motor latency were delayed, indicating impaired regeneration. This result may be relevant to the "double-crush" theory of nerve damage.
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Selected References
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- Baba M., Fowler C. J., Jacobs J. M., Gilliatt R. W. Changes in peripheral nerve fibres distal to a constriction. J Neurol Sci. 1982 May;54(2):197–208. doi: 10.1016/0022-510x(82)90182-4. [DOI] [PubMed] [Google Scholar]
- Baba M., Gilliatt R. W., Harding A. E., Reiners K. Demyelination following diphtheria toxin in the presence of axonal atrophy. J Neurol Sci. 1984 May;64(2):199–211. doi: 10.1016/0022-510x(84)90038-8. [DOI] [PubMed] [Google Scholar]
- Baba M., Gilliatt R. W., Jacobs J. M. Recovery of distal changes after nerve constriction by a ligature. J Neurol Sci. 1983 Aug;60(2):235–246. doi: 10.1016/0022-510x(83)90065-5. [DOI] [PubMed] [Google Scholar]
- Cavanagh J. B., Gysbers M. F. "Dying back" above a nerve ligature produced by acrylamide. Acta Neuropathol. 1980;51(3):169–177. doi: 10.1007/BF00687383. [DOI] [PubMed] [Google Scholar]
- Hoffman P. N., Griffin J. W., Price D. L. Control of axonal caliber by neurofilament transport. J Cell Biol. 1984 Aug;99(2):705–714. doi: 10.1083/jcb.99.2.705. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Krarup C., Gilliatt R. W. Some effects of prolonged constriction on nerve regeneration in the rabbit. J Neurol Sci. 1985 Apr;68(1):1–14. doi: 10.1016/0022-510x(85)90045-0. [DOI] [PubMed] [Google Scholar]
- Morgan-Hughes J. A., Sinclair S., Durston J. H. The pattern of peripheral nerve regeneration induced by crush in rats with severe acrylamide neuropathy. Brain. 1974 Jun;97(2):235–250. doi: 10.1093/brain/97.1.235. [DOI] [PubMed] [Google Scholar]
- Shiraishi S., Le Quesne P. M., Gajree T. The effect of vincristine on nerve regeneration in the rat. An electrophysiological study. J Neurol Sci. 1985 Nov;71(1):9–17. doi: 10.1016/0022-510x(85)90033-4. [DOI] [PubMed] [Google Scholar]
- Upton A. R., McComas A. J. The double crush in nerve entrapment syndromes. Lancet. 1973 Aug 18;2(7825):359–362. doi: 10.1016/s0140-6736(73)93196-6. [DOI] [PubMed] [Google Scholar]
- Williams I. R., Gilliatt R. W. Regeneration distal to a prolonged conduction block. J Neurol Sci. 1977 Aug;33(1-2):267–273. doi: 10.1016/0022-510x(77)90199-x. [DOI] [PubMed] [Google Scholar]