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. 2023 Jun 21;619(7969):394–402. doi: 10.1038/s41586-023-06257-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a,b, Mouse and human AGO2 affinities for 6–11-nt complementary stretches contiguously paired from g2 (a) and for 9-nt complementary stretches contiguously paired from all guide nucleotides (b) for miR-34b, miR-449a, let-7, miR-1, miR-7, miR-124, miR-155, and lsy-6. Mouse AGO2 data are from ref. ³². Human AGO2 data are from ref. ⁵⁷. c, Measurements of MIWI piRISC affinity for its targets (0.1 nM) using nitrocellulose filter binding assay. Mean and the standard deviation of the data from three independent trials are shown. d, MIWI, MILI, EfPiwi, and mouse AGO2 binding affinities for ≥11-nt complementary stretches contiguously paired from all guide nucleotides. Mean and standard deviation from three independent trials are shown.