Table 3.

Average slope of association across regions between perfusion measures and age for each group according to hemisphere

Perfusion Measure Hemisphere	Sex and Genotype	Average Slope with Age across Brain Regions (mean +/− st. dev.)	Comparison with Female ε4 (T-statistic, p-value)
CBF		(ml/100 g/min per decade)
Left	Female ε3	−2.90 ± 1.04	−2.94, 4.62×10−3 *
	Male ε3	−2.85 ± 1.05	−3.10, 2.87×10−3 *
	Female ε4	−3.77 ± 1.37	xxxxxxxxxxxxxxxxxxx
	Male ε4	−3.19 ± 1.01	−1.99, 0.051
	Female ε2	−3.83 ± 1.68	0.14, 0.89
	Male ε2	2.41 ± 1.56	−11.26, < 2.2 × 10−16 *
Right	Female ε3	−2.78 ± 1.27	−4.67, 1.66×10−5 *
	Male ε3	−2.87 ± 1.15	−4.57, 2.51×10−5 *
	Female ε4	−4.41 ± 1.60	xxxxxxxxxxxxxxxxxxx
	Male ε4	−3.35 ± 1.53	−2.81, 6.46×10−3 *
	Female ε2	−3.84 ± 1.70	−1.43, 0.157
	Male ε2	−0.27 ± 1.60	−10.68, 5.00×10−16 *
Bilateral Subcortical	Female ε3	−0.81 ± 1.01	−2.26, 0.032*
	Male ε3	−0.90 ± 0.84	−2.19, 0.038*
	Female ε4	−1.65 ± 0.96	xxxxxxxxxxxxxxxxxxx
	Male ε4	−1.61 ± 0.88	−0.10, 0.920
	Female ε2	−1.77 ± 1.32	−0.27, 0.788
	Male ε2	0.37 ± 1.19	−4.94, 4.44×10−5 *
ATT		(seconds per decade)
Left	Female ε3	0.075 ± 0.016	2.62, 0.011*
	Male ε3	0.074 ± 0.014	3.03, 3.66×10−3 *
	Female ε4	0.087 ± 0.021	xxxxxxxxxxxxxxxxxxx
	Male ε4	0.078 ± 0.024	1.72, 0.09
	Female ε2	0.076 ± 0.020	2.19, 0.03*
	Male ε2	0.040 ± 0.033	6.90, 5.10×10−9 *
Right	Female ε3	0.066 ± 0.015	8.11, 2.56×10−11 *
	Male ε3	0.075 ± 0.015	5.75, 2.87×10−7 *
	Female ε4	0.099 ± 0.019	xxxxxxxxxxxxxxxxxxx
	Male ε4	0.083 ± 0.017	3.78, 3.38×10−4 *
	Female ε2	0.067 ± 0.013	8.09, 3.89×10−11 *
	Male ε2	0.051 ± 0.032	7.61, 4.27×10−10 *
Bilateral Subcortical	Female ε3	0.062 ± 0.011	1.65, 0.115
	Male ε3	0.062 ± 0.018	1.42, 0.169
	Female ε4	0.073 ± 0.023	xxxxxxxxxxxxxxxxxxx
	Male ε4	0.055 ± 0.026	1.98, 0.058
	Female ε2	0.064 ± 0.020	1.19, 0.246
	Male ε2	0.062 ± 0.018	3.95, 6.10×10−4 *

^*= p < 0.05.