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[Preprint]. 2023 Jul 3:2023.07.03.547547. [Version 1] doi: 10.1101/2023.07.03.547547

Fig. 5 |. Subchronic treatment with a ketone ester remodels the older C57BL/6 brain insolublome in vivo.

Fig. 5 |

a, Schematic of cohort and sequential detergent extraction used on insoluble cytosolic brain proteins for proteomic analysis. b, Venn diagram of significantly regulated proteins with ketone ester BH-BD/canola oil control supplementation from each detergent fraction. c-f, Volcano plots of BH-BD/control proteomic samples from each detergent fraction. g-i, Dotplots from clusterProfiler KEGG overrepresentation analysis on (g) upregulated proteins in fraction 2, (h) upregulated proteins in fraction 3, and (i) downregulated proteins in fraction 4.