Skip to main content
[Preprint]. 2023 Jul 4:2023.05.25.542131. [Version 2] doi: 10.1101/2023.05.25.542131

Figure 1. Induction of IT50 responses by challenge infection in humans and rhesus macaques.

Figure 1.

(Ai) The 29 serum samples were tested for IT50s with the challenge strain H. pylori BCM300. Only one individual (no. 1027) showed no induction of IT50, whereas four individuals demonstrated pre-challenge titers (blue). (Aii) The unrelated strain 17875/Le identified five serum samples with bbAbs reaching the risk factor IT50 = 30 (dotted line), ranging from an IT50 of 27 to 85, with a mean IT50 of 49 and a median IT50 of 50 (Table S1A).

(B) Five SPF rhesus macaques were challenge infected with H. pylori J166. Two out of the five SPF animals, no. 2 and no. 3, demonstrated induction of an IT50 response, whereas the other three animals demonstrated high pre-challenge IT50 titers (in blue) as tested with J166 (Bi) and 17875/Leb (Figure S1A)

(Bii) Testing of the serum samples from the two animals no. 2 and no. 3 with the phylogenetically distant (unrelated) Indian strain I9 showed that they also induced IT50 responses of bbAbs (Tables S1B and S1C). ND - Not Determined