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[Preprint]. 2023 Jul 4:2023.05.25.542131. [Version 2] doi: 10.1101/2023.05.25.542131

Figure 6. Vaccination preserved gastric acidity, induced bbAb responses, and reduced H. pylori gastric mucosal attachment.

Figure 6.

(A). The non-vaccinated mice with dysplasia or gastric cancer demonstrated elevated gastric pH, whereas the vaccinated group preserved the gastric acidity over the 12-month period (Wilcoxon p = 0.014*) (Table S4D).

(B) The sera of the vaccinated group of mice demonstrated broadly blocking IT50s against the global series of H. pylori strains, including the challenge onco-strain USU101.

(C) The 1:10 diluted sera of the vaccinated group of mice reduced attachment to the human gastric mucosa by (a) 95% for H. pylori 17875/Leb, (b) 80% for USU101, (c) 73% for J533 (Japan), and (d) 78% for Ch1 (China) compared to the sera of the non-vaccinated controls (Figure S6C).