Skip to main content
NCBI home page
British Journal of Industrial Medicine logoLink to British Journal of Industrial Medicine
. 1990 Feb;47(2):110–115. doi: 10.1136/oem.47.2.110

Sister chromatid exchanges in human lymphocytes treated with silica.

J C Pairon 1, M C Jaurand 1, L Kheuang 1, X Janson 1, P Brochard 1, J Bignon 1
PMCID: PMC1035111  PMID: 2155649

Abstract

The abilities of Min U Sil quartz or tridymite particles to induce sister chromatid exchanges (SCEs) in cultures of human lymphocytes plus monocytes or of human purified lymphocytes were investigated. With cultures of lymphocytes plus monocytes the level of SCEs was significantly enhanced after treatment with tridymite at the highest dose tested (50 micrograms/cm2). No effect was observed with purified lymphocytes. Quartz did not give clear cut results. Complementary experiments with tridymite filtrates suggested that phagocytosis of tridymite particles by monocytes was a necessary step for the induction of SCEs in human lymphocytes.

Full text

PDF
110

Images in this article

113Image
on p.113
114Image
on p.114

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allison A. C., Harington J. S., Birbeck M. An examination of the cytotoxic effects of silica on macrophages. J Exp Med. 1966 Aug 1;124(2):141–154. doi: 10.1084/jem.124.2.141. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Armstrong B. K., McNulty J. C., Levitt L. J., Williams K. A., Hobbs M. S. Mortality in gold and coal miners in Western Australia with special reference to lung cancer. Br J Ind Med. 1979 Aug;36(3):199–205. doi: 10.1136/oem.36.3.199. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Barhad B., Manolescu N., Simionescu N., Ciocnitu V. Changes concerning the external structure of peritoneal macrophages, due to the DQ-12 standard dust. Environ Res. 1983 Aug;31(2):256–265. doi: 10.1016/0013-9351(83)90002-6. [DOI] [PubMed] [Google Scholar]
  4. Finkelstein M., Kusiak R., Suranyi G. Mortality among miners receiving workmen's compensation for silicosis in Ontario: 1940-1975. J Occup Med. 1982 Sep;24(9):663–667. doi: 10.1097/00043764-198209000-00012. [DOI] [PubMed] [Google Scholar]
  5. Forastiere F., Lagorio S., Michelozzi P., Cavariani F., Arca' M., Borgia P., Perucci C., Axelson O. Silica, silicosis and lung cancer among ceramic workers: a case-referent study. Am J Ind Med. 1986;10(4):363–370. doi: 10.1002/ajim.4700100404. [DOI] [PubMed] [Google Scholar]
  6. Goldsmith D. F., Guidotti T. L., Johnston D. R. Does occupational exposure to silica cause lung cancer? Am J Ind Med. 1982;3(4):423–440. doi: 10.1002/ajim.4700030408. [DOI] [PubMed] [Google Scholar]
  7. Harington J. S. Fiber carcinogenesis: epidemiologic observations and the Stanton hypothesis. J Natl Cancer Inst. 1981 Nov;67(5):977–989. [PubMed] [Google Scholar]
  8. Hesterberg T. W., Barrett J. C. Dependence of asbestos- and mineral dust-induced transformation of mammalian cells in culture on fiber dimension. Cancer Res. 1984 May;44(5):2170–2180. [PubMed] [Google Scholar]
  9. Jaurand M. C., Fleury J., Monchaux G., Nebut M., Bignon J. Pleural carcinogenic potency of mineral fibers (asbestos, attapulgite) and their cytotoxicity on cultured cells. J Natl Cancer Inst. 1987 Oct;79(4):797–804. [PubMed] [Google Scholar]
  10. Jaurand M. C., Renier A., Van der Meeren A., Magne L., Pinchon M. C., Bignon J. In vitro growth characteristics of rat mesothelioma cells in culture. Biol Cell. 1986;57(3):249–256. doi: 10.1111/j.1768-322x.1986.tb00481.x. [DOI] [PubMed] [Google Scholar]
  11. Katsnelson B. A., Mokronosova K. A. Non-fibrous mineral dusts and malignant tumors: an epidemiological study of mortality. J Occup Med. 1979 Jan;21(1):15–20. [PubMed] [Google Scholar]
  12. Kelsey K. T., Nagasawa H., Umans R. S., Little J. B. Epidermal growth factor induces cytogenetic damage in mammalian cells. Carcinogenesis. 1987 Apr;8(4):625–627. doi: 10.1093/carcin/8.4.625. [DOI] [PubMed] [Google Scholar]
  13. Koskela R. S., Klockars M., Järvinen E., Kolari P. J., Rossi A. Mortality and disability among granite workers. Scand J Work Environ Health. 1987 Feb;13(1):18–25. doi: 10.5271/sjweh.2085. [DOI] [PubMed] [Google Scholar]
  14. O'Rourke E. J., Halstead S. B., Allison A. C., Platts-Mills T. A. Specific lethality of silica for human peripheral blood mononuclear phagocytes, in vitro. J Immunol Methods. 1978;19(2-3):137–151. doi: 10.1016/0022-1759(78)90174-6. [DOI] [PubMed] [Google Scholar]
  15. Oshimura M., Hesterberg T. W., Tsutsui T., Barrett J. C. Correlation of asbestos-induced cytogenetic effects with cell transformation of Syrian hamster embryo cells in culture. Cancer Res. 1984 Nov;44(11):5017–5022. [PubMed] [Google Scholar]
  16. Schmidt J. A., Oliver C. N., Lepe-Zuniga J. L., Green I., Gery I. Silica-stimulated monocytes release fibroblast proliferation factors identical to interleukin 1. A potential role for interleukin 1 in the pathogenesis of silicosis. J Clin Invest. 1984 May;73(5):1462–1472. doi: 10.1172/JCI111350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Silverstein M., Maizlish N., Park R., Silverstein B., Brodsky L., Mirer F. Mortality among ferrous foundry workers. Am J Ind Med. 1986;10(1):27–43. doi: 10.1002/ajim.4700100105. [DOI] [PubMed] [Google Scholar]
  18. Sinha A. K., Linscombe V. A., Gollapudi B. B., McClintock M. L., Flake R. E., Bodner K. M. The incidence of spontaneous cytogenetic aberrations in lymphocytes cultured from normal humans for 48 and 72 h. Can J Genet Cytol. 1984 Oct;26(5):528–531. doi: 10.1139/g84-084. [DOI] [PubMed] [Google Scholar]
  19. Stanton M. F., Laynard M., Tegeris A., Miller E., May M., Kent E. Carcinogenicity of fibrous glass: pleural response in the rat in relation to fiber dimension. J Natl Cancer Inst. 1977 Mar;58(3):587–603. doi: 10.1093/jnci/58.3.587. [DOI] [PubMed] [Google Scholar]
  20. Steenland K., Beaumont J. A proportionate mortality study of granite cutters. Am J Ind Med. 1986;9(2):189–201. doi: 10.1002/ajim.4700090210. [DOI] [PubMed] [Google Scholar]
  21. Wagner M. F., Wagner J. C. Lymphomas in the Wistar rat after intrapleural inoculation of silica. J Natl Cancer Inst. 1972 Jul;49(1):81–91. [PubMed] [Google Scholar]
  22. Wagner M. M. Pathogenesis of malignant histiocytic lymphoma induced by silica in a colony of specificpathogen-free Wistar rats. J Natl Cancer Inst. 1976 Sep;57(3):509–518. doi: 10.1093/jnci/57.3.509. [DOI] [PubMed] [Google Scholar]
  23. Wagner M. M., Wagner J. C., Davies R., Griffiths D. M. Silica-induced malignant histiocytic lymphoma: incidence linked with strain of rat and type of silica. Br J Cancer. 1980 Jun;41(6):908–917. doi: 10.1038/bjc.1980.168. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Zambon P., Simonato L., Mastrangelo G., Winkelmann R., Saia B., Crepet M. Mortality of workers compensated for silicosis during the period 1959-1963 in the Veneto region of Italy. Scand J Work Environ Health. 1987 Apr;13(2):118–123. doi: 10.5271/sjweh.2072. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Industrial Medicine are provided here courtesy of BMJ Publishing Group

RESOURCES