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. 1990 Sep;47(9):621–626. doi: 10.1136/oem.47.9.621

Comparison of fibre types and size distributions in lung tissues of paraoccupational and occupational cases of malignant mesothelioma.

A R Gibbs 1, D M Griffiths 1, F D Pooley 1, J S Jones 1
PMCID: PMC1035248  PMID: 2207033

Abstract

The results of analysis of mineral fibres in lung tissues from 10 paraoccupational cases of malignant mesothelioma were compared with analysis obtained from seven cases of malignant mesotheliomas that had developed in gas mask workers. Nine of the paraoccupational cases were considered to have developed their tumours because of exposure to asbestos on their husbands' working clothes and one cancer developed in the daughter of a man who had died of asbestosis. The gas mask workers had direct exposure to asbestos while working in a factory that produced military gas masks. The results of mineral fibre analysis in the paraoccupational cases were variable; six showed high crocidolite concentrations, seven raised amosite concentrations and two normal concentrations of all types of asbestos fibre measured. Chrysotile was raised in one case but crocidolite and amosite were also increased. The gas mask workers showed a consistent pattern with high crocidolite concentrations and normal or low concentrations of chrysotile and amosite. Fibre lengths for chrysotile were similar in both groups and predominantly less than 5 microns. Crocidolite fibres tended to be longer in the gas mask workers than in the paraoccupational group and longer than chrysotile in both groups. Amosite fibres tended to be more variable in width than those of chrysotile or crocidolite.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Borow M., Conston A., Livornese L., Schalet N. Mesothelioma following exposure to asbestos: a review of 72 cases. Chest. 1973 Nov;64(5):641–646. doi: 10.1378/chest.64.5.641. [DOI] [PubMed] [Google Scholar]
  2. Brenner J., Sordillo P. P., Magill G. B., Golbey R. B. Malignant mesothelioma of the pleura: review of 123 patients. Cancer. 1982 Jun 1;49(11):2431–2435. doi: 10.1002/1097-0142(19820601)49:11<2431::aid-cncr2820491134>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
  3. Churg A., Wiggs B., Depaoli L., Kampe B., Stevens B. Lung asbestos content in chrysotile workers with mesothelioma. Am Rev Respir Dis. 1984 Dec;130(6):1042–1045. doi: 10.1164/arrd.1984.130.6.1042. [DOI] [PubMed] [Google Scholar]
  4. Cochrane J. C., Webster I. Mesothelioma in relation to asbestos fibre exposure. A review of 70 serial cases. S Afr Med J. 1978 Aug 12;54(7):279–281. [PubMed] [Google Scholar]
  5. Gardner M. J., Saracci R. Effects on health of non-occupational exposure to airborne mineral fibres. IARC Sci Publ. 1989;(90):375–397. [PubMed] [Google Scholar]
  6. Greenberg M., Davies T. A. Mesothelioma register 1967-68. Br J Ind Med. 1974 Apr;31(2):91–104. doi: 10.1136/oem.31.2.91. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Jones J. S., Smith P. G., Pooley F. D., Berry G., Sawle G. W., Madeley R. J., Wignall B. K., Aggarwal A. The consequences of exposure to asbestos dust in a wartime gas-mask factory. IARC Sci Publ. 1980;(30):637–653. [PubMed] [Google Scholar]
  8. Newhouse M. L., Thompson H. Mesothelioma of pleura and peritoneum following exposure to asbestos in the London area. Br J Ind Med. 1965 Oct;22(4):261–269. doi: 10.1136/oem.22.4.261. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Oels H. C., Harrison E. G., Jr, Carr D. T., Bernatz P. E. Diffuse malignant mesothelioma of the pleura: a review of 37 cases. Chest. 1971 Dec;60(6):564–570. doi: 10.1378/chest.60.6.564. [DOI] [PubMed] [Google Scholar]
  10. Pooley F. D., Clark N. J. Quantitative assessment of inorganic fibrous particulates in dust samples with an analytical transmission electron microscope. Ann Occup Hyg. 1979;22(3):253–271. doi: 10.1093/annhyg/22.3.253. [DOI] [PubMed] [Google Scholar]
  11. Tagnon I., Blot W. J., Stroube R. B., Day N. E., Morris L. E., Peace B. B., Fraumeni J. F., Jr Mesothelioma associated with the shipbuilding industry in coastal Virginia. Cancer Res. 1980 Nov;40(11):3875–3879. [PubMed] [Google Scholar]
  12. Vianna N. J., Polan A. K. Non-occupational exposure to asbestos and malignant mesothelioma in females. Lancet. 1978 May 20;1(8073):1061–1063. doi: 10.1016/s0140-6736(78)90911-x. [DOI] [PubMed] [Google Scholar]
  13. WAGNER J. C., SLEGGS C. A., MARCHAND P. Diffuse pleural mesothelioma and asbestos exposure in the North Western Cape Province. Br J Ind Med. 1960 Oct;17:260–271. doi: 10.1136/oem.17.4.260. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Webster I. Asbestos and malignancy. S Afr Med J. 1973 Feb 3;47(5):165–171. [PubMed] [Google Scholar]
  15. Whitwell F., Rawcliffe R. M. Diffuse malignant pleural mesothelioma and asbestos exposure. Thorax. 1971 Jan;26(1):6–22. doi: 10.1136/thx.26.1.6. [DOI] [PMC free article] [PubMed] [Google Scholar]

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