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. 1991 Jan;48(1):30–33. doi: 10.1136/oem.48.1.30

The effect of smoking on the development of allergic disease and specific immunological responses in a factory workforce exposed to humidifier contaminants.

M J Finnegan 1, S Little 1, D J Gordon 1, P K Austwick 1, R D Tee 1, A J Nunn 1, A J Newman-Taylor 1
PMCID: PMC1035308  PMID: 1993157

Abstract

The effects of smoking on the development of work related asthma and on the production of specific IgE and IgG antibodies to antigen from a contaminated humidifier are described for a sample of 258 workers from a printing factory. Current smoking was associated with low production of IgG antibody but with higher production of IgE antibody. No dose response for either antibody was found when numbers of cigarettes or pack-years smoked were considered. Work related asthma was detected in 12 workers by peak flow recordings. Six were current smokers and one was an ex-smoker. One subject with work related asthma had a high (and one a marginal) concentration of specific IgE to humidifier antigen.

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Selected References

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  1. Anderson K., Morrison S. M., Bourke S., Boyd G. Effect of cigarette smoking on the specific antibody response in pigeon fanciers. Thorax. 1988 Oct;43(10):798–800. doi: 10.1136/thx.43.10.798. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Burge P. S., Finnegan M., Horsfield N., Emery D., Austwick P., Davies P. S., Pickering C. A. Occupational asthma in a factory with a contaminated humidifier. Thorax. 1985 Apr;40(4):248–254. doi: 10.1136/thx.40.4.248. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Burge P. S., O'Brien I. M., Harries M. G. Peak flow rate records in the diagnosis of occupational asthma due to colophony. Thorax. 1979 Jun;34(3):308–316. doi: 10.1136/thx.34.3.308. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Burge P. S., O'Brien I. M., Harries M. G. Peak flow rate records in the diagnosis of occupational asthma due to isocyanates. Thorax. 1979 Jun;34(3):317–323. doi: 10.1136/thx.34.3.317. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dales L. G., Friedman G. D., Siegelaub A. B., Seltzer C. C. Cigarette smoking and serum chemistry tests. J Chronic Dis. 1974 Aug;27(6):293–307. doi: 10.1016/0021-9681(74)90093-9. [DOI] [PubMed] [Google Scholar]
  6. Finnegan M. J., Pickering C. A., Davies P. S., Austwick P. K. Factors affecting the development of precipitating antibodies in workers exposed to contaminated humidifiers. Clin Allergy. 1985 May;15(3):281–292. doi: 10.1111/j.1365-2222.1985.tb02286.x. [DOI] [PubMed] [Google Scholar]
  7. Gerrard J. W., Heiner D. C., Ko C. G., Mink J., Meyers A., Dosman J. A. Immunoglobulin levels in smokers and non-smokers. Ann Allergy. 1980 May;44(5):261–262. [PubMed] [Google Scholar]
  8. Hulbert W. C., Walker D. C., Jackson A., Hogg J. C. Airway permeability to horseradish peroxidase in guinea pigs: the repair phase after injury by cigarette smoke. Am Rev Respir Dis. 1981 Mar;123(3):320–326. doi: 10.1164/arrd.1981.123.3.320. [DOI] [PubMed] [Google Scholar]
  9. Venables K. M., Topping M. D., Howe W., Luczynska C. M., Hawkins R., Taylor A. J. Interaction of smoking and atopy in producing specific IgE antibody against a hapten protein conjugate. Br Med J (Clin Res Ed) 1985 Jan 19;290(6463):201–204. doi: 10.1136/bmj.290.6463.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Warren C. P. Extrinsic allergic alveolitis: a disease commoner in non-smokers. Thorax. 1977 Oct;32(5):567–569. doi: 10.1136/thx.32.5.567. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Zetterström O., Nordvall S. L., Björkstén B., Ahlstedt S., Stelander M. Increased IgE antibody responses in rats exposed to tobacco smoke. J Allergy Clin Immunol. 1985 May;75(5):594–598. doi: 10.1016/0091-6749(85)90035-1. [DOI] [PubMed] [Google Scholar]
  12. Zetterström O., Osterman K., Machado L., Johansson S. G. Another smoking hazard: raised serum IgE concentration and increased risk of occupational allergy. Br Med J (Clin Res Ed) 1981 Nov 7;283(6301):1215–1217. doi: 10.1136/bmj.283.6301.1215. [DOI] [PMC free article] [PubMed] [Google Scholar]

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