Abstract
The necropsy findings on the cardiorespiratory organs of 849 South African gold miners were analysed to test the hypothesis that fibrosis of the hilar lymph glands predisposes to the development of parenchymal silicotic nodules. Four hundred and eighty three cases had fibrosed glands, 34% of which also had parenchymal silicosis. By comparison, of 238 cases with silicosis, 88% had fibrosed glands. The proportion of cases with both silicosis and fibrosed glands, as well as those with gland fibrosis only, increased with increasing duration of exposure. As far as can be ascertained from a necropsy series such as this, it is possible that fibrosis of the lymph glands may predispose to the development of lung parenchymal silicosis.
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- Bohning D. E., Atkins H. L., Cohn S. H. Long-term particle clearance in man: normal and impaired. Ann Occup Hyg. 1982;26(1-4):259–271. [PubMed] [Google Scholar]
- Bowden D. H., Adamson I. Y. The role of cell injury and the continuing inflammatory response in the generation of silicotic pulmonary fibrosis. J Pathol. 1984 Nov;144(3):149–161. doi: 10.1002/path.1711440302. [DOI] [PubMed] [Google Scholar]
- Brody A. R., Roe M. W., Evans J. N., Davis G. S. Deposition and translocation of inhaled silica in rats. Quantification of particle distribution, macrophage participation, and function. Lab Invest. 1982 Dec;47(6):533–542. [PubMed] [Google Scholar]
- Corry D., Kulkarni P., Lipscomb M. F. The migration of bronchoalveolar macrophages into hilar lymph nodes. Am J Pathol. 1984 Jun;115(3):321–328. [PMC free article] [PubMed] [Google Scholar]
- Ferin J., Feldstein M. L. Pulmonary clearance and hilar lymph node content in rats after particle exposure. Environ Res. 1978 Jul;16(1-3):342–352. doi: 10.1016/0013-9351(78)90167-6. [DOI] [PubMed] [Google Scholar]
- Green G. M., Jakab G. J., Low R. B., Davis G. S. Defense mechanisms of the respiratory membrane. Am Rev Respir Dis. 1977 Mar;115(3):479–514. doi: 10.1164/arrd.1977.115.3.479. [DOI] [PubMed] [Google Scholar]
- Hahn F. F., Hobbs C. H. The effect of enzyme-induced pulmonary emphysema in Syrian hamsters on the deposition and long-term retention of inhaled particles. Arch Environ Health. 1979 Jul-Aug;34(4):203–211. doi: 10.1080/00039896.1979.10667399. [DOI] [PubMed] [Google Scholar]
- Harmsen A. G., Muggenburg B. A., Snipes M. B., Bice D. E. The role of macrophages in particle translocation from lungs to lymph nodes. Science. 1985 Dec 13;230(4731):1277–1280. doi: 10.1126/science.4071052. [DOI] [PubMed] [Google Scholar]
- Heppleston A. G. Silicotic fibrogenesis: a concept of pulmonary fibrosis. Ann Occup Hyg. 1982;26(1-4):449–462. [PubMed] [Google Scholar]
- Hessel P. A., Goldstein B., Davies J. C., Webster I., Hnizdo E., Landau S. Pathological findings in mine workers: I. Description of the PATHAUT database. Am J Ind Med. 1987;12(1):71–80. doi: 10.1002/ajim.4700120108. [DOI] [PubMed] [Google Scholar]
- Lippmann M., Schlesinger R. B. Interspecies comparisons of particle deposition and mucociliary clearance in tracheobronchial airways. J Toxicol Environ Health. 1984;13(2-3):441–469. doi: 10.1080/15287398409530509. [DOI] [PubMed] [Google Scholar]
- Lippmann M., Yeates D. B., Albert R. E. Deposition, retention, and clearance of inhaled particles. Br J Ind Med. 1980 Nov;37(4):337–362. doi: 10.1136/oem.37.4.337. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Timbrell V. Deposition and retention of fibres in the human lung. Ann Occup Hyg. 1982;26(1-4):347–369. [PubMed] [Google Scholar]