Correction to: Leucine-Rich Alpha-2-Glycoprotein as a non-invasive biomarker for pediatric acute appendicitis: a systematic review and meta-analysis

Correction to: European Journal of Pediatrics https://doi.org/10.1007/s00431-023-04978-2

In the original published version of the above article there were two typographical errors.

1. The text originally says "A standardization of metrics was performed before the quantitative analysis. The random-effect meta-analysis of those studies included 104 cases of PAA and 174 controls (Fig. 3)". However the correct number should have been 103 cases, not 104 (check Fig. 3)

2. On Table 3, on the Kakar et al. (2021) study, for Urinary LRG1 AA (μg/mL), the superindex (CAA) appears as a number and not as a letter. It should have been a "d“, not a "4“, since the legend of the table does not include numbers. The Table 3 has been corrected as follows.

Table 3.

Urinary Leucine-Rich Alpha-2 Glycoprotein summary of publications included in this review

Author	Study design	Age (Range)	Sex M/F	Total N	N in AA	N in CG	Urinary LRG1 AA (μg/mL)	Urinary LRG1 CG (μg/mL)	P (CG vs AA)	P (NCAA vs CAA)	Cutoff μg/mL (CG vs AA)	AUC (AA vs control) (95% CI)	Se (%)	Sp (%)
Kentsis et al. (2010) [10]	Prospective	-	31/36	67	25 (CAA:4)	42	−	−	-		-	0.97 (0.93–1)**	-	-
Kentsis et al. (2012) [11]	Prospective	-	26/23	49	24 (NCAA: 18 CAA: 6)	25	3.9 (0.9-19.3)b (interference adjusted)	0.3 (0.1-0-8)b (interference adjusted)	-		-	0.80 (0.67–0.92)* 0.98 (0.96–1)**	-	-
Kharbanda et al. (2012) [12]	Prospective	3–18	92/84	176	58 (NCAA: 43 CAA: 15)	118	683.5 (122.3–3832.3)b***(UA) [NCAA: 252.7 (106.7–2547.5)b***(UA) CAA: 20576.8 (1750.4–38544.3)b***(UA)] 0.68 (0.12–3.83)b****(UA) 1.54 (2.82)d(UA)	225.2 (46.5–1442.8)b***(UA) 0.23 (0.05–1.44)b****(UA) 0.57 (1.04)e(UA)	0.008(UA)	< 0.001(UA)	42***(UA) 0.04****(UA)	0.63 (0.52–0.73)(UA)	100	23
Salö et al. (2016) [13]	Prospective	3–14	27/17	44	22 (NCAA: 14 CAA: 8)	22	0.078 (0.03–16.78)X,c [NCAA: 0.06 (0.04–0.29)X,c 4.24 (4.38)X,e	0.014 (0.005–0.16)X,c 0.05 (0.04)X,e	< 0.001X	0.003X	0.036X 0.26(UA)	0.86 (0.79–0.99)X 0.65 (0.48–0.81)(UA)	86X 64(UA)	73X 50(UA)
Yap et al. (2019) [14]	Prospective	4–16	81/67	148	42 (CAA: 9 NA: 5)	106	0.22 (0.0003–7.20)X,c 1.91 (1.65)X,e	0.04 (0.0003–3.29)X,c 0.84 (0.65)X,e	0.014X	-	-	0.63 (0.53–0.72)X	-	-
Yap et al. (2020) [15]	Prospective	4–16	15/19	34	17 (NCAA:9 CAA: 8)	17	0.17 (0.026–1.068)X,b 0.42 (0.84)X,d	0.014 (0.002–0.353)X,b 0.12 (0.28)X,d	0.031X	-	1.5X	0.72 (0.54–0.90)X	17.7X	100X
Mahalik et al. (2021) [16]	Prospective	3–16	31/10	41	20 (NCAA: 2 CAA: 5 NOM: 13)	21	8.57 (8.02)a(UA) 0.28 (0.40)X MU not provided	6.68 (7.85)a(UA) 0.22 (0.31)X MU not provided	0.456 (UA) 0.59X	-	-	0.59 (0.41–0.77) not specified if adjusted or unadjusted	-	-
Kakar et al. (2021) [17]	Prospective	7–17	89/64	153	97 (NCAA:45 CAA: 52)	56	NCAA: 0.35 (0.05–1.38)b(UA) CAA: 0.1 (0.03–0.73)b(UA) NCAA: 0.59 (1.02)d(UA) CAA: 0.29 (0.53)d(UA)	0.04 (0.02–0.10)2(UA) 0.05 (0.06)d(UA)	< 0.001(UA)	-	0.175(UA)	0.70 (0.62–0.79)(UA)	54.2	83.9

Bold numbers: standarized metrics and estimated mean (sd) from median (IQR/range) as calculated by authors

LRG1 Leucine-Rich Alpha-2 Glycoprotein, AA Acute appendicitis group, CG Control group, NCAA Non-complicated acute appendicitis, CAA Complicated acute appendicitis, NS non-statistically significant, Se sensitivity, Sp specificity, UA Unadjusted to dehydration through urine creatinine, NA Negative appendectomies, MU Measurement units, NOM non-operative management

*ELISA; **High precision mass spectroscopy; ***ng/mL; ****Conversion to μg/mL from ng/mL X: adjusted to dehydration with urinary creatinine – LRG/Cr (g/mol) XX: adjusted to dehydration with urinary creatinine – units not provided

^aMean (standard deviation)

^bMedian (Interquartile range)

^cMedian (range)

^dMean (standard deviation) obtained from Median (IQR)

^eMean (standard deviation) obtained from median (Range)

The original article has been corrected.