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. 1991 Dec;48(12):808–817. doi: 10.1136/oem.48.12.808

Carcinoma of the lung in Ontario gold miners: possible aetiological factors.

R A Kusiak 1, J Springer 1, A C Ritchie 1, J Muller 1
PMCID: PMC1035460  PMID: 1663386

Abstract

A cohort of 54,128 men who worked in Ontario mines was observed for mortality between 1955 and 1986. Most of these men worked in nickel, gold, or uranium mines; a few worked in silver, iron, lead/zinc, or other ore mines. If mortality that occurred after a man had started to mine uranium was excluded, an excess of carcinoma of the lung was found among the 13,603 Ontario gold miners in the study (standardised mortality ratio (SMR) 129, 95% confidence interval (95% CI) 115-145) and in men who began to mine nickel before 1936 (SMR 141, 95% CI 105-184). The excess mortality from lung cancer in the gold miners was confined to men who began gold mining before 1946. No increase in the mortality from carcinoma of the lung was evident in men who began mining gold after the end of 1945, in men who began mining nickel after 1936, or in men who mined ores other than gold, nickel, and uranium. In the gold mines each year of employment before the end of 1945 was associated with a 6.5% increase in mortality from lung cancer 20 or more years after the miner began working the mines (95% CI 1.6-11.4%); each year of employment before the end of 1945 in mines in which the host rock contained 0.1% arsenic was associated with a 3.1% increase in lung cancer 20 years or more after exposure began (95% CI 1.1-5.1%); and each working level month of exposure to radon decay products was associated with a 1.2% increase in mortality from lung cancer five or more years after exposure began (95% CI 0.02-2.4%). A comparison of two models shows that the excess of lung cancer mortality in Ontario gold miners is associated with exposure to high dust concentrations before 1946, with exposure to arsenic before 1946, and with exposure to radon decay products. No association between the increased incidence of carcinoma of the lung in Ontario gold miners and exposure to mineral fibre could be detected. It is concluded that the excess of carcinoma of the lung in Ontario gold miners is probably due to exposure to arsenic and radon decay products.

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Selected References

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  1. Amandus H. E., Wheeler R. The morbidity and mortality of vermiculite miners and millers exposed to tremolite-actinolite: Part II. Mortality. Am J Ind Med. 1987;11(1):15–26. doi: 10.1002/ajim.4700110103. [DOI] [PubMed] [Google Scholar]
  2. Armstrong B. K., McNulty J. C., Levitt L. J., Williams K. A., Hobbs M. S. Mortality in gold and coal miners in Western Australia with special reference to lung cancer. Br J Ind Med. 1979 Aug;36(3):199–205. doi: 10.1136/oem.36.3.199. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Beard C. M., Jedd M. B., Woolner L. B., Richardson R. L., Bergstralh E. J., Melton L. J., 3rd Fifty-year trend in incidence rates of bronchogenic carcinoma by cell type in Olmsted County, Minnesota. J Natl Cancer Inst. 1988 Nov 2;80(17):1404–1407. doi: 10.1093/jnci/80.17.1404. [DOI] [PubMed] [Google Scholar]
  4. Cox J. D., Yesner R. A. Adenocarcinoma of the lung: recent results from the Veterans Administration Lung Group. Am Rev Respir Dis. 1979 Nov;120(5):1025–1029. doi: 10.1164/arrd.1979.120.5.1025. [DOI] [PubMed] [Google Scholar]
  5. Frome E. L. The analysis of rates using Poisson regression models. Biometrics. 1983 Sep;39(3):665–674. [PubMed] [Google Scholar]
  6. Goldsmith D. F., Guidotti T. L., Johnston D. R. Does occupational exposure to silica cause lung cancer? Am J Ind Med. 1982;3(4):423–440. doi: 10.1002/ajim.4700030408. [DOI] [PubMed] [Google Scholar]
  7. Heppleston A. G. Silica, pneumoconiosis, and carcinoma of the lung. Am J Ind Med. 1985;7(4):285–294. doi: 10.1002/ajim.4700070404. [DOI] [PubMed] [Google Scholar]
  8. McDonald J. C. Silica, silicosis, and lung cancer. Br J Ind Med. 1989 May;46(5):289–291. doi: 10.1136/oem.46.5.289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Roberts R. S., Julian J. A., Muir D. C., Shannon H. S. A study of mortality in workers engaged in the mining, smelting, and refining of nickel. II: Mortality from cancer of the respiratory tract and kidney. Toxicol Ind Health. 1989 Dec;5(6):975–993. doi: 10.1177/074823378900500606. [DOI] [PubMed] [Google Scholar]
  10. Smith M. E., Newcombe H. B. Automated follow-up facilities in Canada for monitoring delayed health effects. Am J Public Health. 1980 Dec;70(12):1261–1268. doi: 10.2105/ajph.70.12.1261. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Taylor P. R., Qiao Y. L., Schatzkin A., Yao S. X., Lubin J., Mao B. L., Rao J. Y., McAdams M., Xuan X. Z., Li J. Y. Relation of arsenic exposure to lung cancer among tin miners in Yunnan Province, China. Br J Ind Med. 1989 Dec;46(12):881–886. doi: 10.1136/oem.46.12.881. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Valaitis J., Warren S., Gamble D. Increasing incidence of adenocarcinoma of the lung. Cancer. 1981 Mar 1;47(5):1042–1046. doi: 10.1002/1097-0142(19810301)47:5<1042::aid-cncr2820470535>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]
  13. Vincent R. G., Pickren J. W., Lane W. W., Bross I., Takita H., Houten L., Gutierrez A. C., Rzepka T. The changing histopathology of lung cancer: a review of 1682 cases. Cancer. 1977 Apr;39(4):1647–1655. doi: 10.1002/1097-0142(197704)39:4<1647::aid-cncr2820390439>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  14. de Klerk N. H., Armstrong B. K., Musk A. W., Hobbs M. S. Cancer mortality in relation to measures of occupational exposure to crocidolite at Wittenoom Gorge in Western Australia. Br J Ind Med. 1989 Aug;46(8):529–536. doi: 10.1136/oem.46.8.529. [DOI] [PMC free article] [PubMed] [Google Scholar]

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