Abstract
A cohort of 4841 men were identified as having worked for more than a year at nine slag wool plants. Some of these men were potentially exposed to man made vitreous fibres (MMVF). The vital status of the entire cohort was ascertained to the end of 1989. Of the 504 deaths that occurred between 1970 and 1989, 61 were attributed to lung cancer (cases). Individually matched controls were randomly selected from the remaining deaths. Attempts were made to locate and interview the surviving families of the cases and controls. The families of three lung cancer cases could not be located and no matched controls were found for another three cases. Included in the final analysis were 55 cases and 98 controls. Estimates of individual exposure to MMVF were based on employment records and industrial hygiene surveys. Data on smoking and histories of employment outside the MMVF industry were obtained from telephone interviews and employment records. Relative risks were calculated for cigarette smoking and exposure to MMVF. No increased risk of lung cancer was found associated with exposure to MMVF, and analysis by cumulative fibre exposure did not indicate any trend. As expected, cigarette smoking was found to be responsible for the observed increase in mortality from lung cancer in this group of MMVF workers, and the risk increased with increasing pack-years of cigarette smoking.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Enterline P. E. Role of manmade mineral fibres in the causation of cancer. Br J Ind Med. 1990 Mar;47(3):145–146. doi: 10.1136/oem.47.3.145. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Esmen N., Corn M., Hammad Y., Whittier D., Kotsko N. Summary of measurements of employee exposure to airborne dust and fiber in sixteen facilities producing man-made mineral fibers. Am Ind Hyg Assoc J. 1979 Feb;40(2):108–117. doi: 10.1080/15298667991429408. [DOI] [PubMed] [Google Scholar]
- HALDANE J. B. The estimation and significance of the logarithm of a ratio of frequencies. Ann Hum Genet. 1956 May;20(4):309–311. doi: 10.1111/j.1469-1809.1955.tb01285.x. [DOI] [PubMed] [Google Scholar]
- MANTEL N., HAENSZEL W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959 Apr;22(4):719–748. [PubMed] [Google Scholar]
- Marsh G. M., Enterline P. E., Stone R. A., Henderson V. L. Mortality among a cohort of US man-made mineral fiber workers: 1985 follow-up. J Occup Med. 1990 Jul;32(7):594–604. doi: 10.1097/00043764-199007000-00009. [DOI] [PubMed] [Google Scholar]
- Prentice R. Use of the logistic model in retrospective studies. Biometrics. 1976 Sep;32(3):599–606. [PubMed] [Google Scholar]
- Rossiter C. E., Douglas D. Role of manmade mineral fibres in the causation of cancer. Br J Ind Med. 1990 Sep;47(9):646–647. doi: 10.1136/oem.47.9.646. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Simonato L., Fletcher A. C., Cherrie J. W., Andersen A., Bertazzi P., Charnay N., Claude J., Dodgson J., Esteve J., Frentzel-Beyme R. The International Agency for Research on Cancer historical cohort study of MMMF production workers in seven European countries: extension of the follow-up. Ann Occup Hyg. 1987;31(4B):603–623. doi: 10.1093/annhyg/31.4b.603. [DOI] [PubMed] [Google Scholar]