Abstract
This study aimed to investigate the pulmonary effects of methylmethacrylate (MMA) in a group of occupationally exposed workers. In the exposed group 20% had chronic cough compared with 1% in controls. Spirometric values at the beginning of the workshift were similar in both groups, but a mild airways obstruction appeared during the workshift. The maximum expiratory flow when 50% of the forced vital capacity remained to be exhaled (MEF50) and the ratio of MEF50 to maximal expiratory flow (MEF50/MEF) decreased significantly during the workshift among exposed workers v controls (p = 0.04 and 0.01 respectively). Results remained unaffected after adjustment for smoking. Exposure to MMA seems to be responsible for a mild airways obstruction but further study on a larger population would be useful.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Blanchet L. J., Bowman D. C., McReynolds H. D. Effects of methyl methacrylate monomer vapors on respiration and circulation in unanesthetized rats. J Prosthet Dent. 1982 Sep;48(3):344–348. doi: 10.1016/0022-3913(82)90026-9. [DOI] [PubMed] [Google Scholar]
- Guberan E., Williams M. K., Walford J., Smith M. M. Circadian variation of F.E.V. in shift workers. Br J Ind Med. 1969 Apr;26(2):121–125. doi: 10.1136/oem.26.2.121. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Guerrin F., Robin H., Boulenguez C. Paramètres respiratoires chez les mineurs pneumoconiotiques du bassin houiller Nord-Pas-de-Calais. Bull Physiopathol Respir (Nancy) 1975 Jul-Aug;11(4):569–588. [PubMed] [Google Scholar]
- Holland C. J., Kim K. C., Malik M. I., Ritter M. A. A histologic and hemodynamic study of the toxic effects of monomeric methyl methacrylate. Clin Orthop Relat Res. 1973 Jan-Feb;(90):262–270. [PubMed] [Google Scholar]
- Jedrychowski W. Styrene and methyl methacrylate in the industrial environment as a risk factor of chronic obstructive lung disease. Int Arch Occup Environ Health. 1982;51(2):151–157. doi: 10.1007/BF00378159. [DOI] [PubMed] [Google Scholar]
- KARPOV B. D. Metilmetakrilat s tochki zreniia glgieny truda. Gig Sanit. 1954 Oct;10:25–28. [PubMed] [Google Scholar]
- Kapp M. C., Schachter E. N., Beck G. J., Maunder L. R., Witek T. J., Jr The shape of the maximum expiratory flow volume curve. Chest. 1988 Oct;94(4):799–806. doi: 10.1378/chest.94.4.799. [DOI] [PubMed] [Google Scholar]
- Kessler M. J., Kupper J. L., Brown R. J. Accidental methyl methacrylate inhalation toxicity in a rhesus monkey (Macaca mulatta). Lab Anim Sci. 1977 Jun;27(3):388–390. [PubMed] [Google Scholar]
- Knudson R. J., Lebowitz M. D., Holberg C. J., Burrows B. Changes in the normal maximal expiratory flow-volume curve with growth and aging. Am Rev Respir Dis. 1983 Jun;127(6):725–734. doi: 10.1164/arrd.1983.127.6.725. [DOI] [PubMed] [Google Scholar]
- Knudson R. J., Slatin R. C., Lebowitz M. D., Burrows B. The maximal expiratory flow-volume curve. Normal standards, variability, and effects of age. Am Rev Respir Dis. 1976 May;113(5):587–600. doi: 10.1164/arrd.1976.113.5.587. [DOI] [PubMed] [Google Scholar]
- Lehnigk B., Thiele E., Wosnitzka H. Respiratorische Funktionsstörungen durch Agrochemikalien-exposition. Z Erkr Atmungsorgane. 1985;164(3):267–269. [PubMed] [Google Scholar]
- Nemery B., Van Leemputten R., Goemaere E., Veriter C., Brasseur L. Lung function measurements over 21 days shiftwork in steelworkers from a strandcasting department. Br J Ind Med. 1985 Sep;42(9):601–611. doi: 10.1136/oem.42.9.601. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Raje R. R., Ahmad S., Weisbroth S. H. Methylmethacrylate: tissue distribution and pulmonary damage in rats following acute inhalation. Res Commun Chem Pathol Pharmacol. 1985 Oct;50(1):151–154. [PubMed] [Google Scholar]