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. 2023 Jul 5;62(14):2147–2160. doi: 10.1021/acs.biochem.2c00599

Figure 4.

Figure 4

Binding and selectivity data for 2-sulfonyl/sulfonamide pyrimidines. (A) Evidence for binding of H3B-960 to WRN helicase domain by isothermal titration calorimetry. Selectivity of H3B-859 (B) and H3B-219 (C) for WRN (black) versus BLM (red) and RecQL1 helicase domain (blue). Eleven-point dose responses were evaluated with the ADP-Glo assay as described in the Experimental Section. WRN IC50 values were 865 and 171 nM for H3B-859 and H3B-219, respectively, whereas IC50 values for BLM and RecQL1 helicase domain were greater than 50 μM.