Table 2.
Fifteen top metabolites from the death-related metabolomic fingerprint and standard laboratory variables in the CANONIC cohort ranked by their predictive ability through C-index estimation and their corresponding position and C-index in the PREDICT cohort
| Variables | Discovery set: CANONIC study cohort | Validation set: PREDICT study cohort | ||
| Rank | C-index | Rank | C-index | |
| Metabolite | ||||
| 4-Hydroxy-3-methoxyphenylglycol sulfate | 1 | 0.822 | 1 | 0.760 |
| Hexanoylcarnitine | 2 | 0.799 | 4 | 0.721 |
| L-Saccharopine | 3 | 0.786 | 12 | 0.704 |
| N-Acetyl-aspartil-glutamate | 4 | 0.782 | 9 | 0.709 |
| p-Hydroxyphenyllactic acid | 5 | 0.777 | 2 | 0.733 |
| D-Galacturonic acid | 6 | 0.766 | 3 | 0.724 |
| N-Acetyl-L-alanine | 7 | 0.759 | 20 | 0.684 |
| Butyrylcarnitine | 8 | 0.759 | 21 | 0.681 |
| Cystathionine | 9 | 0.757 | 8 | 0.711 |
| Octanoylcarnitine | 10 | 0.747 | 10 | 0.707 |
| 5'-Deoxy-5'-(methylthio)adenosine | 11 | 0.747 | 11 | 0.707 |
| β-Pseudouridine | 12 | 0.746 | 26 | 0.664 |
| Phenyllactic acid | 13 | 0.742 | 14 | 0.699 |
| N6,N6,N6-Trimethyl-L-lysine | 14 | 0.742 | 5 | 0.719 |
| N-Acetyl-L-tyrosine | 15 | 0.741 | 18 | 0.687 |
| Standard laboratory variables* | ||||
| INR | 1 | 0.726 | 1 | 0.687 |
| Bilirubin | 2 | 0.695 | 2 | 0.676 |
| Creatinine | 3 | 0.672 | 3 | 0.621 |
| Sodium | 4 | 0.630 | 4 | 0.616 |
*Standard laboratory variables consider the cut-offs presented in the definition of the MELDNa score.
INR, international normalised ratio.