Fig. 4.

Naringenin and Naringin improve Cardiac Endothelial Cell functioning. NGN and NAR promote the scavenging of ROS and free radicals generated from NADPH oxidase and the respiratory activity of the mitochondria. They also inhibit inflammatory cytokine action and attenuate inflammation via the inhibition of NFκB and regulation of leukocyte adhesion. NGN and NAR prevent the formation of toxic peroxynitrite from NO and facilitate endothelial cell vasodilation and smooth blood flow through the heart vessels.