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PLOS One logoLink to PLOS One
. 2023 Jul 21;18(7):e0273139. doi: 10.1371/journal.pone.0273139

Factors influencing the effectiveness of nature-based interventions (NBIs) aimed at improving mental health and wellbeing: Protocol of an umbrella review

Topaz Shrestha 1,*,#, Cheryl Voon Yi Chi 1,#, Marica Cassarino 1,2,#, Sarah Foley 1,#, Zelda Di Blasi 1,#
Editor: Md Nazmul Huda3
PMCID: PMC10361498  PMID: 37478105

Abstract

Several systematic reviews support the use of nature–based interventions (NBIs) as a mechanism of enhancing mental health and wellbeing. However, the available evidence for the effectiveness of these interventions is fragmentary and mixed. The heterogeneity of existing evidence and significant fragmentation of knowledge within the field make it difficult to draw firm conclusions regarding the effectiveness of NBIs. This mixed method umbrella review aims to synthesise evidence on the effectiveness of nature–based interventions through a summative review of existing published systematic reviews and meta-analyses. A systematic search in PsycINFO, PubMed, Greenfile, Web of Science, Embase, Scopus, Academic Search Complete (EBSCO), Environment Complete (EBSCO), Cochrane Library, CINAHL, Health Policy Reference Centre and Google Scholar will be performed from inception to present. The search strategy will aim to find published systematic reviews of nature–based interventions (NBIs) where improving health and wellbeing is an explicit goal. This is a mixed method review, and systematic reviews with both quantitative and qualitative data synthesis will be considered. Two authors will independently perform the literature search, record screening, data extraction, and quality assessment of each included systematic review and meta-analysis. The individual qualitative and quantitative syntheses will be conducted in parallel and combined in an overarching narrative synthesis. The quantitative evidence will be used to assess the strength and direction of the effect of nature–based interventions on mental health and wellbeing outcomes. Evidence drawn from qualitative studies will be analysed and synthesised to understand the various pathways to engagement, involvement process and experiential factors that may mediate experiences. The risk of bias of the systematic reviews will be assessed using a 16-item Assessment of Multiple Systematic Reviews 2 (AMSTAR2) checklist.

Trail registration: This review is registered on PROSPERO (CRD42022329179).

Introduction

Disconnection from nature

Connecting with nature is an important element of many people’s lives, and a substantial body of research supports nature’s restorative influence on our mental health and wellbeing [13]. More recently, the benefits of nature–based interactions are becoming increasingly acknowledged across disciplines from Positive Psychology and Urban Planning to Medicine and Public Health. This research demonstrates a consistent positive trend between engagement with nature and improved physical and mental health outcomes [4, 5]. Therefore, it is of significant concern that urbanisation, environmental degradation, and the challenges of modern living are leading to a reduction in engagement with the natural environment. A presiding narrative in industrialised nations is that modern-urbanized lifestyles have diminished healthy human relationships with natural environments resulting in a multitude of health issues and reduced wellbeing [4, 6]. Many of us seem physically and psychologically disconnected from nature, which has implications for the wellbeing of the environment and individuals [7]. While long-acknowledged as practices across cultures, nature–based therapeutic interventions have grown substantially in number and type in recent years [1, 8]. Western science is beginning to realise what Indigenous cultures have always known–engagement with the natural environment can support, enhance, and restore our health and wellbeing [5].

Nature-based interventions

There is growing interdisciplinary interest in the potential for ‘nature–based interventions’ (NBIs) to promote and restore mental health and wellbeing. NBIs can facilitate change through a relatively structured promotion of nature–based experiences. Although a generally accepted definition is lacking, NBIs can be defined as intentional programmes, activities or strategies that aim to engage people in nature–based experiences with the specific objective of enhancing health and wellbeing [9, 10]. NBIs are deliberate therapeutic processes recognising nature–human kinship [11]. These interventions can be broadly categorised into those that change the environment in which people live, learn, work, recreate and heal (for example, the provision of parks in cities or gardens in hospitals) and those that alter behaviour (for example, engaging people through organized programmes such as wilderness therapy) [9]. Considerable variety exists in practice, for example, biophilic design in urban settings, the incorporation of green and blue spaces in cities, the development of community gardens [12, 13]. Additionally, there are interventions which revolve around more active engagement with nature. For example, green exercise programmes, ecotherapy [3, 10], therapeutic horticulture, sea swimming initiatives, forest bathing and expedition-based wilderness programmes [5, 8]. These interventions can be centred around green space, blue space, or an amalgamation of both. Greenspace is habitually comprised of vegetation and is associated with natural elements. There are two interpretations of greenspace. Firstly, the interpretation that greenspace refers to areas of vegetation in a landscape, such as forests and wilderness areas, gardens and backyards, street trees and parks, farmland, geological formations, coastal regions, and food crops. This interpretation encompasses the overarching concept of nature or natural areas in general. The second interpretation focuses on urban vegetation, including parks, gardens, urban forests, and farms − usually relating to a vegetated variation of open space [12]. Blue space can be defined as ‘all visible, outdoor, natural surface waters with potential for the promotion of human health and wellbeing’, e.g., rivers, lakes, coasts, sea, etc. (p. 52). Research has highlighted the specific potential for freshwater, coastal and marine ecosystems to promote and restore mental health and wellbeing [2, 11]. It is evident that there is considerable overlap between blue and green spaces. However, these offer very different sensory experiences and are used in varying ways with distinct health outcomes and benefits that are often overlooked and remain poorly understood.

Many existing reviews of NBIs define nature exposure using metrics such as the amount of green or blue space present in any given area (e.g., number of parks with access to greenery, lakes, etc.) [1, 14, 15]. An inherent limitation of these metrics is that they assume exposure revolves around geographic proximity without considering whether nearby nature was used, of good quality, or whether it was accessible (e.g., near a busy road crossing) [16, 17]. This has resulted in a call for researchers to broaden their definition of nature exposure and investigate different types of natural settings and their characteristics [1, 14, 18]. To address this, the current review focused on NBIs where ‘nature-based’ encompasses what Bloomfield [3] refers to as “time spent outside in places defined as rich in natural beauty and biodiversity” (p. 82). This includes both biodiverse, unregulated, wild nature lacking human involvement [3] and publicly accessible, managed urban green spaces or blues paces (e.g., parks, gardens/allotments, and artificial lakes/reservoirs) [19]. Understanding what NBIs are available and the various factors influencing the effectiveness of these interventions is necessary if we are to gain a clear picture of the current state of the research.

Meta perspective on the rise of nature-based interventions

It is important to acknowledge that nature-based interventions are part of a complex system affected by cultural, social, and political factors [1, 16]. The recent proliferation of NBIs may be linked to a broader cultural shift towards the ‘natural’ [3, 16]. Environmentalism has become topical and it is possible that NBIs are an ‘eco-fad’ that is trending right now. Over the past 30 years many individuals and organisations have begun to promote the human-centric approach to the protection of natural resources [7, 11]. This human-centric perspective on conservation highlights the interrelationship between humans and nature and our responsibility to protect the planet. The urgency of the climate crisis and subsequent pressure people feel could explain the interest in NBIs. Many of us are experiencing new emotions, such as climate anxiety and ecological guilt and these feelings of accountability may result in this mass movement towards nature-based solutions [7, 8, 11]. Additionally, the rise in interest in NBIs may be partially economically motivated, as western welfare states realise increasingly its cost and time-effectiveness [1113, 16]. Lost in the rise of these eco-fads is an objective appraisal of whether these actions have a tangible impact on human and environmental health, or merely pacifying our ecological guilt. Environmental policies are designed primarily to construct a green image—rather than deliver results. Given the complex social and economic criticism of NBI’s as eco-fads, we acknowledge this dimension and are committed to providing a critical lens to NBIs.

Nature-based interventions, mental health, and wellbeing

Globally, the growing interest in the restorative potential of NBIs, within healthcare, seems to be driven by a global mental health crisis and the rise of non-communicable diseases [1, 20]. The issue of mental health and wellbeing is particularly pertinent with rising suicide rates and lack of funding for services highlighted internationally [21]. Moreover, evidence shows a significant gravitation towards natural environments during the COVID-19 pandemic and that this increased engagement with nature may have buffered the negative mental and behavioural impacts of recurrent lockdowns [22]. Public health administrations are beginning to acknowledge the significance of proximity to, and engagement with, natural environments ‘as an upstream health promotion intervention for populations’ [23]. The recognition of the value of nature and place as a determinant of mental health and wellbeing presents a crucial opportunity for struggling healthcare systems seeking new and cost-effective services [24].

Reviewing the evidence on nature-based interventions

Several comparative studies, randomized controlled trials, observational studies, and subsequently systematic reviews and meta-analyses have been conducted to investigate the efficacy of nature–based interventions (NBIs) on mental health and wellbeing outcomes [2, 10, 25, 26]. Considering the extensive number of systematic reviews assessing NBIs, it is crucial to synthesise the findings of these reviews to consolidate the evidence and better inform science and practice [9]. Umbrella reviews are systematic overviews of systematic reviews and/or meta-analyses that can be used to provide a summary of the evidence from multiple research syntheses. Systematic reviews conducted with optimal methodological rigour can provide high-quality evidence informing further research and the development of effective policies. With the increased number of systematic reviews of NBIs available, a logical and necessary next step is to conduct an umbrella review of existing systematic reviews, allowing the findings of separate reviews and meta-analyses to be compared, subsequently providing decision makers in healthcare with an overall synthesis of the body of information available [27]. This is a rapidly growing field, and the recent interest in nature–based solutions (NBS) and the proliferation of ‘nature–based interventions’ (NBIs) is surpassing the policy and knowledge base. This has resulted in a general lack of understanding regarding the practical implementation of NBIs within public planning and policy and the factors influencing the effectiveness of these interventions [9, 28]. This can only limit the leveraging of natural environments to improve health and wellbeing outcomes, potentially resulting in ineffective and ill–targeted investment decisions. A higher-order or meta-level synthesis is required to make sense of this evidence. This will provide a broader picture of the types of interventions available, the specific mental health and wellbeing outcomes they impact upon, the drivers and barriers to using NBIs, and the methodological quality of the existing research. There is significant fragmentation of knowledge within the field and previous studies highlight evidence gaps concerning effectiveness of interventions [1, 9, 24]. The universal application of NBIs to different groups and the diversity of nature itself has led to significant heterogeneity of intervention designs [9]. There is a need for a comprehensive overview of existing evidence regarding the effectiveness of interventions, particularly given the plurality of types of interventions, delivery approaches, and patient groups [16]. Moreover, vague intervention descriptions and an absence of theoretical frameworks guiding NBI design has limited the critical appraisal of these interventions [2731].

Objectives of the review

The aim of this mixed method umbrella review is to synthesise the evidence on the effectiveness of NBIs aimed at enhancing mental health and wellbeing through a summative review of existing published systematic reviews and meta-analyses. This review aims to explore the drivers influencing the effectiveness of NBIs by exploring factors that encourage engagement in NBIs and potential barriers to involvement in these interventions. The decision to include both quantitative and qualitative evidence was based on the commitment to provide an extensive and accurate summary of the existing evidence of NBIs. It is expected that the quantitative evidence will be used to assess the strength and direction of the effect of NBIs on mental health and wellbeing outcomes, thereby providing insight into the effectiveness of interventions. In contrast, the qualitative studies will provide a more nuanced perspective of the factors influencing the effectiveness of nature–based interventions. Our qualitative analysis will attempt to capture the holistic experience of nature–based interventions for participants involved and help to understand the experience and meaning of participation in nature–based interventions. By providing insight into pathways to engagement and potential factors which may mediate their experiences of these interventions. The mixed-methods synthesis of will provide a comprehensive overview of current evidence and will help to identify gaps in knowledge, potential quality needs and directions for future research. Further knowledge and communication about the effectiveness of interventions is likely to be a valuable precursor for their use [9].

The overall objective of this mixed method umbrella review is to synthesize the evidence on the effectiveness of nature–based interventions, aimed at enhancing mental health and wellbeing to explore the overarching research question: What are the factors influencing the effectiveness of nature-based interventions? Accordingly, our specific objectives were to identify: 1) what nature–based interventions (NBIs) are available, 2) what specific mental health and wellbeing outcomes might they achieve for whom, and 3) what are the factors that drive or limit the effectiveness of NBIs.

This umbrella review will provide a comprehensive synthesis of the growing evidence on NBIs to offer recommendations for future research, policymaking, and practice.

Methods and analysis

Protocol registration

The umbrella review will adhere to the predesigned protocol that we developed based on the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) guidelines [32] (S1 Table). This project was registered with the International Prospective Register of Systematic Reviews (PROSPERO) (registration number CRD42022329179).

Data sources and search strategies

We will conduct a comprehensive umbrella review of all available systematic reviews on the topic using the methodology described by Smith et al., which outlines the methodology for conducting reviews of systematic reviews of healthcare interventions [31]. We will adopt the Joanna Briggs Institute (JBI) methodology for umbrella reviews, which provide further guidelines specific for synthesizing the findings from multiple reviews [29]. The systematic overview resulting from the conduct of an umbrella review is useful to explore whether the evidence base around a topic is consistent or contradictory, and to examine the reasons for the findings [29, 33].

A systematic search of the following twelve databases will be completed: PsycINFO, PubMed, Greenfile, Web of Science, Embase, Scopus, Academic Search Complete (EBSCO), Environment Complete (EBSCO), Cochrane Library, CINAHL, Health Policy Reference Centre and Google Scholar. No date limit will be placed on the search. The search strategy will aim to find published systematic reviews of nature–based interventions (NBIs) where improving health and wellbeing is an explicit goal. Our search strategy will be comprised of three elements. Search terms relating to (i) nature–based interventions/green or blue spaces and (ii) mental health and wellbeing outcomes will be combined with (iii) systematic review OR meta-analysis and searched for in title, abstract, and keywords. We will search databases using a set of search query including keywords and Boolean operators to retrieve the relevant literature as per the objective of this review. The search strategy consists of keywords related to the natural environment, mental health, and systematic review. The selection of search terms was based on existing theories and research defining nature–based interventions as well as initial preliminary searches for the umbrella review. Each search term will be applied twice—initially by itself, then paired with the term “systematic review” to reduce the number of returns on some of the searches, with additional searches using hyphenated variants where appropriate. The search terms for nature–based interventions/green or blue spaces and health/wellbeing outcomes will be combined with the Boolean AND; within each group the Boolean OR will be used. Aiming for as complete coverage as possible, the search may be widened, beyond the protocol, by scanning identified articles’ bibliographies and “snowballing.” The detailed search strategy, which was developed by the full research team in consultation with a Faculty Librarian, is available in S2 Table. The results of the search will be fully reported in the final study and presented in a flowchart following the PRISMA guidelines.

Our inclusion criteria are based on the Cochrane criteria for what constitutes a systematic review as well as the AMSTAR 2 tool for the quality assessment of systematic reviews, in order to incorporate only high-quality systematic reviews [34]. The AMSTAR 2 domains will be used as indicators of eligibility for our study. We will include all systematic reviews and meta-analyses that investigate the impact of nature–based interventions (NBIs) on mental health and wellbeing. The search will be limited to peer-reviewed studies published in English and results will be filtered, by study type, to include solely systematic reviews. Our decision to include only peer-reviewed studies is based on our commitment to provide a synthesis of high-quality evidence which has gone through a meticulous and rigorous review process [27, 29]. Additionally, our decision to include only studies published in English is the result of limited resources and the language constraints of our review team. Including studies published in non-English languages would have increased resource challenges in relation to time, costs, and expertise in non-English languages. This umbrella review will include systematic reviews, with or without meta-analysis, which review any type of nature–based intervention (NBI). Unpublished grey literature will not be included due to the fact that the focus of this review is on systematic reviews and meta-analyses with quality assessments, which are typically found in academic peer-reviewed publications. Inclusion criteria will be restricted to studies with defined search terms, inclusion criteria and quality assessment.

The above-mentioned criteria are fundamental components of a high-quality systematic review [1]. Systematic reviews which examine both randomized controlled trials (RCT) and non-randomized controlled trials and observational studies (which do not have a control group) will be included in this overview. The rationale behind this decision is that the field largely consists of non-randomized trials, and excluding systematic reviews which include non-RCT studies may result in an incomplete synthesis of findings [35].

Data selection

A PRISMA flow chart will be developed to record the screening and selection of studies. Once all records from our search are collected, EndNote 20 software (Thomson Reuters, Toronto, Ontario, Canada) will be used to remove duplicates and screen literature. A 2-stage screening process will be completed independently by two researchers (TS and CVYC); the first screening stage will consider titles and abstracts, while full-texts will be checked in the second stage. Interrater reliability (IRR) will be reported at all three stages of screening and data extraction to ensure consistency and clarity [36]. Any disagreements will be resolved by discussion or by the involvement of a third reviewer (ZDB) until consensus is reached. When titles and abstracts are insufficient to determine whether to include or exclude reviews, we will download full texts to determine eligibility. Based on the umbrella review methodology, when numerous systematic reviews provide duplicated datasets for the same comparison, the systematic review with the greatest number of studies providing study-level effect estimates will be retained for further analysis [37]. The following are the detailed inclusion criteria:

Participants

There are no age or gender restrictions for participants. Children, adolescents, and adults with or without mental and/or physical health problems. The routes to participation (e.g., motivations and barriers) will be considered throughout analysis to further understand how nature–based interventions could influence health and wellbeing of participants and in what contexts. It is anticipated that the qualitative evidence will provide insight into the routes to participation in nature–based interventions.

Interventions

In this umbrella review we will include any systematic review focused on real nature–based interventions (NBIs)/exposure to green and blue spaces. Real nature is defined as a broad range of green landscapes in the indoor and outdoor environment. This includes green spaces (e.g., botanic garden, or tree canopy), indoor nature (e.g., potted plants, green walls, or flowers), or real nature views (e.g., window views) [38]. For this study, NBIs are defined as programmes, activities or strategies that aim to engage people in nature–based experiences with the specific intention of improving health and wellbeing outcomes [9].

In order to adopt a comprehensive definition of nature exposure which considers different types of natural settings and their characteristics [1, 14, 18], the current review focused on NBIs which included exposure to both ‘wild’/unregulated natural environments which have minimal human involvement and managed/man-made green and blue spaces such as urban parks, ponds, garden allotments etc. Additionally, we included NBIs which focused on biophilic design for example, green walls in cities and the overall incorporation of nature into infrastructure. All included studies must encompass NBIs which integrate explicit and purposeful nature contact, incorporating blue or green space through direct nature exposure to an authentic natural setting (e.g., walking in nature/ being in a park, etc.). We will exclude interventions that examined the effects of artificial nature, virtual/simulated nature, animal therapy, animal interventions, fish tanks, or nature sounds. The justification of this revolves around our focus on ‘real nature’ [38] and our conception of NBIs where ‘nature-based’ encompasses what Bloomfield [3] refers to as “time spent outside in places defined as rich in natural beauty and/or biodiversity” (p. 82).

Outcomes

All systematic reviews which assess the mental health and wellbeing impacts experienced by individuals following active participation in a nature–based interventions will be included. Mental health, as defined by the World Health Organization (WHO), is “a state of wellbeing in which the individual realizes his or her own abilities, can cope with the normal stresses of life, can work productively and fruitfully, and is able to make a contribution to his or her community” [39]. Wellbeing encompasses positive emotions and mood, the absence of negative emotions, satisfaction with life, fulfilment, and positive functioning [40, 41]. All included interventions must have the promotion of mental health and wellbeing outcomes as an explicit goal (i.e., programmes that solely aim to connect people with nature without the objective of also delivering health and wellbeing benefits will be excluded).

Quantitative research

Includable primary outcomes will include any recognised measure of mental health and wellbeing assessed using self-reported and objective measures. Outcomes can be defined as the psychological effects of NBIs related to mental health and wellbeing (e.g., life satisfaction, quality of life, vitality, stress, anxiety, exhaustion, burnout, and depression). The outcomes can be categorized as: (i) mental health indices, (ii) restoration and recovery, (iii) executive functioning/cognitive ability, (iv) work and life satisfaction, and (v) psychophysiological indicators of psychological wellbeing (e.g., cortisol levels).

Qualitative research

Includable qualitative evidence will be in the form of themes, metaphors and concepts relating to the meaning, experience and perceived effects of nature–based interventions and any factors that help or hinder their success, e.g., direct quotes, and author analysis of qualitative findings.

Data collection and verification

We will develop a standardized form for extracting data from each systematic review. The ad hoc data extraction sheet will be developed and piloted prior to data collection and will be used to ensure a controlled analysis and data retrieval. Two authors will collect the variables listed below and cross-check the accuracy of the data. A plan for data extraction is shown in Table 1 below:

Table 1. Data extraction table.

Data Extraction Item
Author(s)
Year of publication
Country of origin
Number of articles included in systematic review
Search terms
Type/definition of intervention reviewed
Type/definition of mental health and wellbeing outcome(s) reviewed
Quality assessment
Quantitative findings–main findings and effect sizes
Qualitative findings–themes, metaphors and concepts relating to the meaning, experience, and perceived effects of nature–based interventions and any factors influencing effectiveness of NBIs e.g., direct quotes, and author analysis of qualitative findings

Critical appraisal

Methodological quality of the included systematic reviews will be assessed by two independent researchers using the Assessment of Multiple Systematic Reviews 2 (AMSTAR2, an updated version of AMSTAR) tool, a 16-item checklist used to critically rate the quality of an individual systematic review as high, moderate, low and critically low based on the total score of the AMSTAR2 [34]. The AMSTAR 2 tool has been updated to facilitate a more detailed assessment of systematic reviews that include both randomised and non-randomised studies of healthcare interventions. The risks of bias will be analysed in relation to the particular design, conduct, and synthesis of the systematic review. Risk of bias assessment will assess methods of randomization and intervention allocation. In the case of disagreements, a discussion will be conducted with a third reviewer to reach a consensus. In the case of insufficient or additional information, the study authors will be contacted.

Data analysis

The strategy for data synthesis will consist of firstly extracting the quantitative and qualitative data from each review, which will be entered into the screening and data extraction table. Findings will be structured around a synthesis of the characteristics of included studies, the classification of interventions used, and the types of outcomes reported. A narrative synthesis will be used to present the potential factors influencing the effectiveness of NBIs. The umbrella review format will enable a unique form of evidence synthesis whereby the researchers can stand back and gain a comprehensive summary of the breadth of research on NBIs. The results will be reported descriptively in the text, and in tables. Visual techniques will be used to present the quantitative synthesis in a comprehensive format, for example a narrative approach table, indicating factors such as strength and direction/s of results and study quality) will be used to visually depict the trends in the results. Similarly, visual techniques will be used to illustrate the qualitative data and synthesis, e.g., graphs, tables, flow charts etc.

Quantitative studies will provide insight into the strength and direction of evidence of effect. However, we anticipate a limited scope for meta-analysis due to the likelihood that many individual studies will be included in more than one review, resulting in inaccurate statistical power and a risk for misleading results. Additionally, the heterogeneity of intervention type given the plurality of disciplinary origins of these interventions will further impede the potential for meta-analysis. As our review considers one type of “intervention” (nature–based), however of varying composition (e.g. ecotherapy, green infrastructure, or blue environments), and its effect on several different health outcomes, we consider the challenge of dissecting each included review, extracting the results from each individual study included, and the subsequent amalgamation of the results, to be of insubstantial value given the heterogeneity in the outcome measures and the unreliable accuracy of a pooled effect estimate [42]. A narrative synthesis approach will be used if the quantitative study design or outcomes are so heterogeneous to impede meta-analysis [43]. Where possible and appropriate, statistical heterogeneity will be assessed following the Cochrane 6.3 guidance [1]. Should trials of clinical relevance be included, an assessment of clinical heterogeneity, considering variability in participants, outcomes and characteristics of the intervention, will be assessed following guidance by Gagnier et al., [55].

Qualitative studies will be used to provide a more nuanced perspective of the factors influencing the effectiveness of nature–based interventions. It is anticipated that the qualitative analysis will capture the holistic experience of NBIs, for participants involved, and help to understand the experience and meaning of participation in NBIs, highlighting pathways to engagement and potential factors that mediate their experiences. Qualitative findings will be synthesised narratively by developing key themes related to enablers and barriers of effectiveness [43]. The synthesis will be sensitive to factors which may affect the impact on wellbeing, such as the demographics of participants, the context of the activities, and the implementation and specifics of the interventions.

Overarching synthesis

The individual qualitative and quantitative syntheses will be conducted in parallel and then combined in an overarching narrative synthesis [43]. Narrative synthesis supports the contextualised integration of diverse forms of evidence helping researchers to understand the phenomenon of interest. This approach is especially suited to reviews of complex intervention effectiveness such as NBIs. If data permits, the analysis will be sensitive to impacts on different groups of people (e.g., age, those with mental ill health, those recovering from specific conditions or addictions). The qualitative evidence will also be used to explore those factors which help or hinder the successful development, implementation, and sustainability of the form of NBI for different groups of people. The combined narrative synthesis will be used to develop a conceptual model [44]. The model will be grounded in formulated on the synthesised results of both the qualitative and quantitative evidence. We are committed to practising reflexivity throughout the research process. We will consider the cultural, social, political, and ideological origins of your own perspectives throughout the study. We will critically examine our own role, assumptions, beliefs, pre-existing potential bias and impact on the data during all stages of the research process including: (a) formulation of the research questions (b) data collection and (c) data analysis. We hope that this reflexive engagement by multiple analysts will enhance the quality of this study [3].

Based on the evidence collated, we may decide to split the review into two separate sister papers, separated by quantitative and qualitative evidence—What do we know about NBI, parts I and II. We see significant merit in this distinction provided the evidence will support such a divide. We have currently completed full-text screening. The decision to separate evidence will be made when piloting our data extraction sheet. By piloting the extraction sheet gauge the potential scope to divide the review into quantitative and qualitative evidence, i.e., are there enough quantitative and qualitative reviews to warrant this divide and do the mixed reviews present their findings in a way that would facilitate the separation of quantitative and qualitative evidence.

Discussion

By incorporating evidence from published systematic reviews and meta-analyses, we will provide a comprehensive overview of the factors influencing effectiveness of nature-based interventions (NBIs) which are aimed at enhancing mental health and wellbeing.

The recent and rapid proliferation of ‘nature–based interventions’ (NBIs), is surpassing the policy and knowledge base. This results in challenges in understanding and evaluating their tangible impact on the publics’ mental health and wellbeing [5, 12, 24]. There is a need for further evidence regarding the effectiveness of interventions. While multiple interventions exist, all proposing engagement with nature as means of enhancing mental health and wellbeing, there is a dearth of guidance as to what NBIs are available and the drivers influencing their effectiveness [9]. This can only impede the leveraging of natural environments to improve mental health and wellbeing outcomes, potentially leading to ineffective and ill–targeted investment decisions. We postulate that this knowledge gap exists due to the diversity of intervention designs and therapeutic approaches. Moreover, the lack of financial prioritization allocated to cost-effective NBIs impedes the potential for such interventions to ameliorate health and wellbeing on a larger scale. With the rising prevalence of substandard mental health, and the established link between poor mental health and a myriad of other noncommunicable diseases, the general population bears a significant socioeconomic burden [45, 46]. We recognise that NBIs are part of a complex system influenced by social, cultural, and political factors. Subsequently, the pathways between health and nature are linked to health inequalities [1, 16, 47, 48]. It is often the most underprivileged, i.e., people with lower socioeconomic status, who benefit from access to and engagement with high-quality nature [12, 16, 49]. Nature–based interventions could be a cost and time-effective mechanism of enhancing wellbeing at a population level. However, a concerted and systematic effort is required to understand what factors influence the effectiveness of interventions [16]. Additionally, there is evidence that policy and decision makers around the world, who are interested in cost-effective health improvement programmes, are progressively supporting the promotion of ‘nature–based solutions’ (NBS) [1, 50, 51]. It is therefore timely that the evidence of effectiveness of nature–based interventions is reviewed in a systematic and rigorous manner.

With the increase in the number of systematic reviews conducted, a necessary next step to provide practitioners in healthcare with the evidence they need to successfully develop NBIs. An umbrella review was chosen to provide an overview of the evidence from multiple research syntheses through an overall examination of the body of systematic and analytic reviews. This form of evidence synthesis supports comparative analysis. This method allows us to collectively evaluate the state of the evidence in broad categories of research, which may make more sense in clinical practice rather than evaluating [them] one by one [27]. The umbrella reviews’ most distinguishing feature is that only the highest level of evidence, namely other systematic reviews, and meta-analyses, are considered for inclusion [29, 31]. By synthesising high-level evidence of the factors influencing the effectiveness of NBIs we will gain a comprehensive overview of the strengths and weaknesses of such interventions. Thus, supporting the implementation of interventions which are more targeted and subsequently more effective. Whilst there seems to be a considerable body of literature which has aimed to understand the potential mental health and wellbeing benefits of nature–based interventions, there are no available umbrella reviews that have addressed the factors influencing the effectiveness of interventions. Several linked reviews were identified but these were either limited in scope (e.g., focusing specifically on nature’s role in psychotherapy [4], assessing exclusively built/urban natural environments [1, 52, 53], or don’t focus explicitly on nature–based interventions e.g. exploring exposure to natural environments in general rather than intentional NBIs [2]. Moreover, to the best of our knowledge, this is the first mixed method umbrella review that summarizes the factors influencing the effectiveness of nature–based interventions (NBIs) thus providing insight into the practical application of NBIs within public planning and policy. The focus on mental health and wellbeing outcomes in wider contexts will provide a better understanding of potential approaches and pathways which are needed to support an evidenced-based knowledge of the importance of NBIs.

The empirical evidence relating to our research questions, both quantitative and qualitative, will be identified, appraised, and synthesized. Evidence drawn from qualitative studies will help to understand the diverse pathways to engagement and factors that mediate participants’ experiences of NBIs. The aim of this umbrella review is not to repeat the searches, assessment of eligibility or risk of bias for the included reviews, but rather to provide an overall picture of findings for the specific phenomenon of NBIs. In contrast to systematic reviews or meta-analyses limited to one treatment comparison, an umbrella review can provide a broader picture of many intervention types [29, 54]. This is more effective in informing guidelines and clinical practice when all the management options must be considered. This umbrella review intends to provide a resource for decision–makers in government and other interested organisations by outlining potential interventions, the specific mental health and wellbeing outcomes they might achieve for whom, the drivers influencing the extent to which these interventions succeed, and the target beneficiaries. We expect that the findings of this review will provide a roadmap for decision–makers and support the integration of NBIs into public planning and policy.

There are some limitations inherent to our umbrella review. It is anticipated that the included systematic reviews will vary in their heterogeneity and quality. This is likely due to the diversity of intervention types, disciplinary origins of these interventions, delivery approaches, and patient groups for which they are being used [9, 16, 55, 56]. In addition, heterogeneity is driven by the breadth of the aims and uses of the interventions that will be potentially includable in the review, which will range from exposure to nature through to specific therapeutic interventions. As a result, we anticipate a limited scope for meta-analysis. We will use the AMSTAR 2 checklist to assess the risk of bias of each included study and address the concerns around the quality of included reviews. Given the resource constraints faced in undertaking this study, we assess only English literature. We acknowledge that this is a limitation of this work as it may privilege a particular perspective and reduces generalizability. Additionally, as mentioned in the introduction, the recent proliferation of NBIs may be linked to a cultural movement towards environmentalism and a desire to be perceived as environmentally conscious. We recognise that papers overtly critical of NBIs may be missing from the evidence base we collate. Where such a perspective is missing, we are committed to applying a more reflective and critical lens to the evidence to provide a comprehensive overview of the research.

Despite anticipated limitations, we believe that the result of this umbrella review will benefit practitioners, landscape, and urban design professionals, policymakers, and the general public. A synthesis of the evidence including the methodological quality of the research will also be of great importance to researchers in this field.

Supporting information

S1 Table. PRISMA-P checklist.

(DOC)

S2 Table. Search strategy.

(DOCX)

Data Availability

This is a protocol for a systematic umbrella review, thus no empirical data has been collected to prepare this manuscript. No datasets were generated or analysed during the current study.

Funding Statement

The author(s) received no specific funding for this work.

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Decision Letter 0

Nyanyiwe Masingi Mbeye

13 Oct 2022

PONE-D-22-21700Factors influencing the effectiveness of nature–based Interventions (NBIs) aimed at improving mental health and wellbeing: Protocol of an umbrella reviewPLOS ONE

Dear Dr. Shrestha,

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Reviewer #2: Yes

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Reviewer #1: No

Reviewer #2: Yes

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Reviewer #2: Yes

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(Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Thank you for the read on an important topic. I am currently teaching social work students and many of them are interested in this! Overall good language and written with clearly in-depth knowledge and passion for the topic.

I would suggest the following as improvements before publishing:

My major overall concern while reading is that the scope of the intended review is very wide. To get an overview of every intervention and try to compare them seems almost unfeasible. While I applaud the obvious advantages of trying to cover both qualitative and quantitative papers, it may in fact be better if you were to split this into two separate sister papers, "What do we know about NBI, part I" and II. If you intend to integrate both qualitative and quantitative data into all the 5 parts of the analysis I fear the result will be unwieldy. Alternatively the aims outlined ca. line 172 could be cut to 2 or 3, not 5. Without this I fear the protocol will not be replicable.

INTRO

Thorough but maybe a bit disorganised -could be written with a more clear narrative and also use subheadings if allowed by Plos. For instance, small changes like a paragraph change in line 153 would help greatly on readability.

In line 160 you probably do not mean "alternatively" but maybe "in contrast" or something along those lines.

Readability could also be improved by shortcutting phrases like "It is anticipated that the qualitative analysis will capture..." -you could instead write "Our qualitative analysis will attempt to capture" -in general avoid the passive form throughout.The sentence in question is in general hard to follow and could probably be split in two or three.

Look for potential improvements like the above throughout.

In addition to the organisational points I am also missing a critical voice -there could be other reasons NBI are trending right now, e.g. that it is indeed a trend to be "natural", and that the increased interest does not in fact reflect actual effect. It would be good if the intro acknowledged this and made explicit an intent to include papers overtly critical to the concept of nature based interventions. And I would like to see that you are aware that such papers may to be missing from the reviews you are reviewing, and that you have considered what to do if this is the case.

I would also argue that the rise seen in interest in NBI may be partially economically motivated, and a part of the realisation on the part of western welfare states that institutions are very expensive to run, while self-help walking groups are much much cheaper. In other words I would wish for the intro to include a brief yet more nuanced and perhaps wider metaperspective on the rise of NBIs.

METHODS

Prisma and Prospero -good!

The "Data collection and verification" section of the paper could be much improved by providing a visual representation (table) of the extracted data plan you outline.

You say "Exact methods of synthesis for the included qualitative research will depend on the nature of the evidence identified" - in my opinion this would need to be refined quite a bit before publishing as it is too vague. Especially with regards to replicability, this would be essential in case someone else wants to use your methods section as a blueprint for a similar project.

Ethics: I think whenever you are going to be investigating qualitative data, it would be pertinent to include your own pre-existing potential biases, especially given that you are most likely planning to do a narrative review.

Reviewer #2: 1. Consider extending the searches beyond May 2022

2. Aim of the umbrella review lacks clarity in lines 153-155-Revise

3. The overall objective in lines 171-175 is convoluted and confusing to the reader as it includes the aim. It also does not speak to the aim outlined in lines 153-155-Revise

4. Specify the methodology being referred to in line 190-191

5. Definition of “umbrella review” in lines 193-195 should come earlier in the introduction section

6. The following statement in line 203 sounds incomplete: “No date limit will be placed on the search until.”

7. Justify why search will be limited to peer-reviewed studies published in English only-lines 230-231-This will make you leave out articles written in other languages

8. Justify why unpublished grey literature will not be included in the review

9. Definition of NBIs presented in lines 271-273 should come earlier in the introduction section

10. Avoid unnecessary repetitions e.g lines 275-279 are a repletion of lines 71-75

11. Consider utilizing a PRIMA flow diagram as part of Methods to indicate who the selection of studies will be done

12. Provide adequate details about how statistical and clinical heterogeneity will be determined and how this will affect data analysis

13. Manuscript will benefit from grammar and language editing

**********

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Reviewer #1: No

Reviewer #2: Yes: Genesis Chorwe-Sungani, PhD

**********

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Attachment

Submitted filename: PLOS ONE Review.docx

PLoS One. 2023 Jul 21;18(7):e0273139. doi: 10.1371/journal.pone.0273139.r002

Author response to Decision Letter 0


25 Jan 2023

Response to Editor and Reviewers Comments

Dear Editor,

We would like to extend our sincerest thanks to you and the reviewers for taking the time to evaluate our manuscript and for allowing us to revise our study. We are now submitting our revised manuscript with tracked changes and a point-by-point response to the editor and both reviewers, which can be found below.

Academic Editor’s comments:

1. Please ensure that your manuscript meets PLOS ONE's style requirements, including those for file naming.

Thank you to the editors for this guidance. We have formatted our manuscript in line with PLOS ONE’s style guidelines.

2. During our internal evaluation of the manuscript, we found significant text overlap throughout the whole manuscript between your submission and previous work .

We would like to make you aware that copying extracts from previous publications, especially outside the methods section, word-for-word, is unacceptable. In addition, the reproduction of text from published reports has implications for the copyright that may apply to the publications.

Please revise the manuscript to rephrase the duplicated text, cite your sources, and provide details as to how the current manuscript advances on previous work. Please note that further consideration is dependent on the submission of a manuscript that addresses these concerns about the overlap in text with published work.

We will carefully review your manuscript upon resubmission and further consideration of the manuscript is dependent on the text overlap being addressed in full. Please ensure that your revision is thorough as failure to address the concerns to our satisfaction may result in your submission not being considered further.

Thank you for bringing our attention to this. Academic integrity is central to our practice, and we would never knowingly take from others work. We have addressed this concern by using Turnitin and Grammarly software to detect any text overlap. All sources have been correctly cited and we provide clear reference to how the current manuscript advances on previous work. In our check, we found that most of the overlapping was with the preprint the submitted manuscript which has been published with medrxiv: https://www.medrxiv.org/. No further considerable overlaps were identified by us. Please do not hesitate to let us know if further issues with originality arise.

3. We note that you have stated that you will provide repository information for your data at acceptance. Should your manuscript be accepted for publication, we will hold it until you provide the relevant accession numbers or DOIs necessary to access your data. If you wish to make changes to your Data Availability statement, please describe these changes in your cover letter and we will update your Data Availability statement to reflect the information you provide.

Thank you for this point. This is a protocol for a systematic umbrella review, thus no empirical data has been collected to prepare this manuscript. We apologize for any errors in the Data availability statement. A note about this has been made in the cover letter.

Reviewer #1

Thank you for the read on an important topic. I am currently teaching social work students and many of them are interested in this! Overall good language and written with clearly in-depth knowledge and passion for the topic.

I would suggest the following as improvements before publishing:

My major overall concern while reading is that the scope of the intended review is very wide. To get an overview of every intervention and try to compare them seems almost unfeasible. While I applaud the obvious advantages of trying to cover both qualitative and quantitative papers, it may in fact be better if you were to split this into two separate sister papers, "What do we know about NBI, part I" and II. If you intend to integrate both qualitative and quantitative data into all the 5 parts of the analysis I fear the result will be unwieldy. Alternatively the aims outlined ca. line 172 could be cut to 2 or 3, not 5. Without this I fear the protocol will not be replicable.

We would like to extend thanks to R1 for proposing the idea of two separate sister papers - separated into quantitative and qualitative evidence. We recognise your concerns regarding the scope of our review and objectives. We see significant merit in this idea provided the evidence would support such a divide. We have currently completed full-text screening and we are in the process of developing and piloting our data extraction sheet. By piloting the extraction sheet we aim to gauge if there is scope to divide the review into quantitative and qualitative evidence i.e. are there enough quantitative and qualitative reviews to warrant this and do the mixed-reviews present their findings in a way that would facilitate the separation of quantitative and qualitative evidence. We have added this stipulation to the protocol. See lines 620-628, p.19. Additionally we have addressed your concerns about the scope of the review being too wide by integrating objectives 3 and 4 into one (what are the factors that drive or limit the effectiveness of NBIs), and removing objective 5 but keep it as the ultimate goal of our review. See lines 281-289, p. 9

INTRO

Thorough but maybe a bit disorganised -could be written with a more clear narrative and also use subheadings if allowed by Plos. For instance, small changes like a paragraph change in line 153 would help greatly on readability.

We have organised the introduction to provide a more clear narrative of our study. Additionally, we have incorporated suggestions such as adding subheadings and paragraph changes. See introduction.

In line 160 you probably do not mean "alternatively" but maybe "in contrast" or something along those lines.

This has been amended. See line 249.

Readability could also be improved by shortcutting phrases like "It is anticipated that the qualitative analysis will capture..." -you could instead write "Our qualitative analysis will attempt to capture" -in general, avoid the passive form throughout. The sentence in question is in general hard to follow and could probably be split in two or three.

Look for potential improvements like the above throughout.

This particular example has been edited (See line 249-250) and we have altered similar instances throughout the manuscript where the passive form is used.

In addition to the organisational points I am also missing a critical voice -there could be other reasons NBI are trending right now, e.g. that it is indeed a trend to be "natural", and that the increased interest does not in fact reflect actual effect. It would be good if the intro acknowledged this and made explicit an intent to include papers overtly critical to the concept of nature based interventions. And I would like to see that you are aware that such papers may to be missing from the reviews you are reviewing and that you have considered what to do if this is the case.

I would also argue that the rise seen in interest in NBI may be partially economically motivated, and a part of the realisation on the part of western welfare states that institutions are very expensive to run, while self-help walking groups are much cheaper. In other words, I would wish for the intro to include a brief yet more nuanced and perhaps wider metaperspective on the rise of NBIs.

Thank you for this suggestion. We have provided a nuanced metaperspective on the rise of NBIs as suggested. We have also provided a more critical perspective on NBIs. See lines 142-174, p.5.

METHODS

Prisma and Prospero -good!

The "Data collection and verification" section of the paper could be much improved by providing a visual representation (table) of the extracted data plan you outline.

We have provided a visual representation (Table 1, p. 15-16) to represent our data extraction plan. See lines

You say "Exact methods of synthesis for the included qualitative research will depend on the nature of the evidence identified" - in my opinion this would need to be refined quite a bit before publishing as it is too vague. Especially with regards to replicability, this would be essential in case someone else wants to use your methods section as a blueprint for a similar project.

We have refined this statement to provide more detail on our methods of synthesis for the included qualitative studies. See lines 566-568, p. 18.

Ethics: I think whenever you are going to be investigating qualitative data, it would be pertinent to include your own pre-existing potential biases, especially given that you are most likely planning to do a narrative review.

Thank you for raising this issue. We have added a section outlining our commitment to practice reflexivity throughout the study. We will critically examine our own role, assumptions, beliefs, pre-existing potential bias and impact on the data during all stages of the research process including: (a) formulation of the research questions (b) data collection and (c ) data analysis. We hope that this reflexive engagement by multiple analysts will enhance the quality of this research. See lines 612-618, p.19.

Reviewer #2

Thank you R2 for your helpful and constructive feedback. Below we outline our response to your comments and subsequent action taken.

1. Consider extending the searches beyond May 2022

The search will be extended beyond May 2022. No date limit will be placed on the search. See line 322, p.10.

2. Aim of the umbrella review lacks clarity in lines 153-155-Revise

We have clarified our aim by adding more specific detail to this explanation. See lines 189-194.

3. The overall objective in lines 171-175 is convoluted and confusing to the reader as it includes the aim.

It also does not speak to the aim outlined in lines 153-155-Revise

We have edited this to make sure that our overall objective links to the aim mentioned earlier in the introduction. Additionally, we have integrated objectives 3 and 4 into one (what are the factors that drive or limit the effectiveness of NBIs), and removed objective 5 but keep it as the ultimate goal of our review. We hope that this has provided a more concise overview of our specific objectives. See lines 237—289, p.9.

4. Specify the methodology being referred to in line 190-191

The specific methodology we were referring to has been outlined. See lines 246-247.

5. Definition of “umbrella review” in lines 193-195 should come earlier in the introduction section

Definition has been moved to earlier in the introduction section. See lines 200-202, p.7.

6. The following statement in line 203 sounds incomplete: “No date limit will be placed on the search until.”

This has been corrected. See line 322.

7. Justify why search will be limited to peer-reviewed studies published in English only-lines 230-231-This will make you leave out articles written in other languages

Our decision to include only peer-reviewed studies is based on our commitment to provide a synthesis of high quality evidence which has gone through a meticulous and rigorous review process. Our decision to include only studies published in English is the result of limited resources and the language constraints of our review team. While we acknowledge that this is a limitation of our review, including studies published in non-English languages would have increased resource challenges in relation to time, costs, and expertise in non-English languages. We have clarified this in the manuscript. See lines 357-363, p.11.

8. Justify why unpublished grey literature will not be included in the review

This decision is linked to our aforementioned commitment to include only studies which have gone through a rigorous review process which impacts upon study quality. This has been clarified (Aromataris et al., 2015) https://journals.lww.com/ijebh/Fulltext/2015/09000/Summarizing_systematic_reviews__methodological.4.aspx See lines 357-363.

9. Definition of NBIs presented in lines 271-273 should come earlier in the introduction section

This definition is now in the introduction section. See lines 311-312.

10. Avoid unnecessary repetitions e.g lines 275-279 are a repletion of lines 71-75

This repetition has been removed.

11. Consider utilizing a PRIMA flow diagram as part of Methods to indicate who the selection of studies will be done

We thank the Reviewer for this suggestion. We have made more evident our approach to data selection at p.12, where we have clarified the following:

“A PRISMA flow chart will be developed to record the screening and selection of studies. Once all records from our search are collected, EndNote 20 software (Thomson Reuters, Toronto, Ontario, Canada) will be used to remove duplicates and screen literature. A 2-stage screening process will be completed independently by two researchers (TS and CVYC); the first screening stage will consider titles and abstracts, while full-texts will be checked in the second stage”

A completed PRISMA flow diagram has not been included in the protocol as we would not be able to populate it until screening is completed.

12. Provide adequate details about how statistical and clinical heterogeneity will be determined and how this will affect data analysis

We have clarified in the Data Analysis section (p.18, line 556-560) that:

“Where possible and appropriate, statistical heterogeneity will be assessed following the Crochane 6.3 guidance (Deeks et al., 2022). Should trials of clinical relevance be included, an assessment of clinical heterogeneity, considering variability in participants, outcomes and characteristics of the intervention, will be assessed following guidance by Gagnier et al. (2013).”

13. Manuscript will benefit from grammar and language editing

Our review team has assessed the text for any grammar or language issues. Additionally, we have used specific software i.e. Grammarly to make changes to our grammar and language throughout the manuscript.

Attachment

Submitted filename: Response to Reviewers.docx

Decision Letter 1

Md Nazmul Huda

15 May 2023

PONE-D-22-21700R1Factors influencing the effectiveness of nature–based Interventions (NBIs) aimed at improving mental health and wellbeing: Protocol of an umbrella reviewPLOS ONE

Dear Dr. Topaz,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

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Md. Nazmul Huda, PhD

Academic Editor

PLOS ONE

Journal Requirements:

Please review your reference list to ensure that it is complete and correct. If you have cited papers that have been retracted, please include the rationale for doing so in the manuscript text, or remove these references and replace them with relevant current references. Any changes to the reference list should be mentioned in the rebuttal letter that accompanies your revised manuscript. If you need to cite a retracted article, indicate the article’s retracted status in the References list and also include a citation and full reference for the retraction notice.

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Does the manuscript provide a valid rationale for the proposed study, with clearly identified and justified research questions?

The research question outlined is expected to address a valid academic problem or topic and contribute to the base of knowledge in the field.

Reviewer #2: Yes

Reviewer #3: Yes

Reviewer #4: Yes

Reviewer #5: Yes

Reviewer #6: Partly

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2. Is the protocol technically sound and planned in a manner that will lead to a meaningful outcome and allow testing the stated hypotheses?

The manuscript should describe the methods in sufficient detail to prevent undisclosed flexibility in the experimental procedure or analysis pipeline, including sufficient outcome-neutral conditions (e.g. necessary controls, absence of floor or ceiling effects) to test the proposed hypotheses and a statistical power analysis where applicable. As there may be aspects of the methodology and analysis which can only be refined once the work is undertaken, authors should outline potential assumptions and explicitly describe what aspects of the proposed analyses, if any, are exploratory.

Reviewer #2: Yes

Reviewer #3: Yes

Reviewer #4: Partly

Reviewer #5: Yes

Reviewer #6: Yes

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3. Is the methodology feasible and described in sufficient detail to allow the work to be replicable?

Descriptions of methods and materials in the protocol should be reported in sufficient detail for another researcher to reproduce all experiments and analyses. The protocol should describe the appropriate controls, sample size calculations, and replication needed to ensure that the data are robust and reproducible.

Reviewer #2: Yes

Reviewer #3: Yes

Reviewer #4: Yes

Reviewer #5: Yes

Reviewer #6: Yes

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4. Have the authors described where all data underlying the findings will be made available when the study is complete?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception, at the time of publication. The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #2: Yes

Reviewer #3: Yes

Reviewer #4: No

Reviewer #5: Yes

Reviewer #6: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #2: Yes

Reviewer #3: Yes

Reviewer #4: Yes

Reviewer #5: No

Reviewer #6: Yes

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6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above and, if applicable, provide comments about issues authors must address before this protocol can be accepted for publication. You may also include additional comments for the author, including concerns about research or publication ethics.

You may also provide optional suggestions and comments to authors that they might find helpful in planning their study.

(Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #2: The paper can be accepted for publication though responses for comment number 7 and 8 appears to be not adequate

Reviewer #3: Dear Author

Thank you for the opportunity to review your manuscript again. I appreciate the efforts you have made to address the previous reviewer's comments. Overall, the manuscript is well-written, and the methodology is sound. However, I still have a few observations which are mostly positive in nature.

Firstly, I agree that an umbrella review is necessary, given the number of systematic reviews on this topic. The authors' approach of only working with systematic reviews seems to be appropriate, but I am concerned about the vastness of the topic. Please ensure that the scope of the review is clearly defined, and the search strategy is comprehensive.

Secondly, I have no concerns with the methodology of the mixed-method review described in the protocol. The authors have provided sufficient explanation for the end date and English language criteria. I appreciate the thoroughness of the methodology.

Thirdly, while the introduction is well-structured and easy to follow now, I would have preferred a few examples of NBI in addition to the definition(s). This would help readers like me to better understand the concept.

Fourthly, since most of the concerns raised by the previous reviewer have been addressed, I find the protocol to be robust. However, there is undue repetition in the 'Intervention' section. Specifically, line 312-316 and 318-321 are exact copies of line 94-98 and 100-105 from the 'Introduction' section. Please avoid such repetition and try to explain it differently in the 'Intervention' section to make it clear to the reader. By differently, I mean use the space in the intervention section to expand on what you said in the Intro section.

In summary, the manuscript is well-written, and the methodology is sound. My observations are mostly positive, and I appreciate the authors' efforts to address the previous reviewer's comments. Please consider my feedback while revising the protocol.

Reviewer #4: 1/ good topics but its too abroad better to be restricted to specific area will be more informative

2/ if the time extended beyond that period 2022 will b better

Reviewer #5: 1. References : some of the references are outdated . authors can chose the recent 5 years papers.

2. Authors should simply the text and focus on grammar more.

Reviewer #6: Dear Editor,

Thank you for sending me a manuscript of study Protocol PONE-D-22-21700R1 for reviewing titled ‘Factors influencing the effectiveness of nature–based Interventions (NBIs) aimed at improving mental health and wellbeing: Protocol of an umbrella review’.

Since this manuscript has already been reviewed by another reviewer earlier, it was of ample advantages for me to go for reviewing for the second time.

The very title: ‘Factors influencing the effectiveness of nature–based Interventions (NBIs) aimed at improving mental health and wellbeing: Protocol of an umbrella review’ – Loos okay and self-explanatory.

To start with:

The abstract seems well described in a consiced yet in a meaningful way. Alike other systematic reviews supporting NBIs as a mechanism of enhancing mental health and wellbeing, the authors claimed that available evidence for the effectiveness of NBIs remain fragmentary and mixed that yields significant fragmentation of knowledge within the field making it difficult to draw firm conclusions on an NBI.

Aim(s) and Objective(s):

The authors, aimed to study this mixed method umbrella review by synthesizing evidence on the effectiveness of NBIs as a summative review of available published systematic reviews and meta-analyses. The authors conducted a systematic search using 13 search engines, like: PsycINFO, PubMed, Greenfile, Web of Science, Embase, Scopus, Academic Search Complete (EBSCO), Environment Complete (EBSCO), Cochrane Library, CINAHL, Health Policy Reference Center and Google Scholar for a period of its inception (as the authors claimed) up to May 2022.

Methodological drives:

Strategically, the authors’ aimed to find out all (not mentioned though) published systematic reviews of NBIs yielding improved health and wellbeing as their explicit goal.

Then, for synthesis of this systematic reviews they used a mixed method (quantitative & qualitative data) engaging two independent authors who did the following steps essential for a modest review:

- Literature search,

- Record screening,

- Data extracting, and then,

- Quality assessment of each of all (not clear) systematic review and meta-analysis.

- The authors synthesized all individually qualitative & quantitative syntheses parallelly but then combined those in an overarching narrative synthesis and used the quantitative evidence to assess strength and direction of effect of NBIs on outcome of mental health and wellbeing.

Yielded results and findings:

- The authors analyzed evidences drawn from qualitative studies and synthesized to those to understand various pathways to engagement, process of involvement and experiential factors which may have mediated experiences.

- However, the authors assessed the calculated risk of bias of systematic reviews will be using a 16-item Assessment of Multiple Systematic Reviews 2 (AMSTAR2) checklist

- Finally, registered on international database of prospectively registered systematic reviews in health and social care- PROSPERO (CRD42022329179) to record & maintain that as a permanent record.

My comment on the response of authors to earlier two reviewers including reply to editor’s earlier comments, are as below:

Now, that this manuscript has been reviewed by two others including the editorial input I can guess that the state of this manuscript currently looks great as a post edited copy. However, followings remain my final comment on this pre-reviewed manuscript, par se.

Authors 1st reply to editorial review/comment earlier:

I am glad to notice that the authors revised the manuscript with point specific answers to the editor using tracked changes method.

The five Responses by the authors to each of the Academic Editor’s comments (Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corp.) remains acceptable and good to notice that accepting all the 5 comments/ queries that were raised by the editor, the authors worked on those points seriously and thus replied modestly yet logically, pointing out the corrections they made as follows:

1.The authors ensured that their manuscript met PLOS ONE's style requirements and file naming.

2.The authors agreed, attended and corrected all the error to correct those as per editor’s advices what they found during internal evaluation of the manuscript.

3.So, now it is the time for the editor to carefully review the manuscript finally that they resubmitted. But, to me it now looks okay.

4.To reply to the editor’s query to ensure by the authors that their revision is thorough so it can be acceptable in this stage, I think.

5.Regarding R-1 comment on providing repository information for author’s data, I think the authors reply is to be validated by the editor’s office yet, if it remains acceptable what the author’s pointed out on their protocol (a systematic umbrella review) may not have any empirical data to be used in preparing this manuscript, and, so the authors apologized for any errors in the data availability statement including a note on this has been reflected in their cover letter.

Next, looking at the critically raised comments by Reviewer #1 and the replies by the authors also though seems to me as acceptable but it entirely depends on R-1 and the editorial board to re-examining the authors reactions, opinions and replies, if acceptable.

However, the authors reply to this proposition that when they liked the proposed idea by R-1 of preparing two separate sister papers analyzing quantitative & qualitative evidences, separately, but explained that the scope of their review & objectives was not really the same but they had significant merit in Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation this idea provided the evidence would support such a divide. And, that the authors informed that they have completed full-text screening and on the process of developing/piloting their data extraction. By piloting the extraction sheet, they aim to gauge if there is any scope to divide the review into quantitative and qualitative evidence. However, the authors have added this stipulation to the protocol on lines 620-628, on page 19.

Moreover, to reply R-1’s concern on the scope of review being too wide by integrating objectives 3 and 4 into one …. the authors replied that they have organized the introduction to provide a clearer narrative of the study. Additionally, they have incorporated suggestions such as adding subheadings and paragraph changes. ……. However, the authors has edited (See line 249-250) and altered similar instances throughout the manuscript where the passive form is used.

In addition to the organizational points from R-1 point of view, in missing out a critical voice -there could be other reasons NBI are trending right now, e.g. that it is indeed a trend to be "natural", and that the increased interest does not in fact reflect actual effect….etc.., the authors replied that they have also provided a nuanced meta-perspective on the rise of NBIs that the R-1 suggested and they also provided a more critical perspective on NBIs. See lines 142-174, p.5.

METHODS Prisma and Prospero -good! …… The "Data collection and verification" section of the paper could be much improved by providing a visual representation (table) of the extracted data plan outlined……… … etc. The authors already refined this statement to provide more detail on our methods of synthesis for the included qualitative studies. See lines 566-568, p. 18.

On the point that R-1 raised on Ethics- the authors have added a section outlining their commitment to practice reflexivity throughout the study. And they said that they will critically examine our own role, assumptions, beliefs, pre-existing potential bias and impact on the data during all stages of the research process including: (a) formulation of the research questions, (b) data collection and (c) data analysis. Moreover, they hope that reflexive engagement by multiple analysts will enhance the quality of this research. See lines 612-618, p.19.

Thanking the Reviewer #2 for helpful and constructive feedback the authors outlined their response to R-2 comments and action taken subsequently. Moreover, as per R-2 comment the authors agreed and considered extending searches beyond May 2022.

Then, to reply to a valid point that R#2 raised on ‘Aim of the umbrella review lacks clarity in lines 153-155’ suggested for revising, the authors agreed to R-2 to clarify the aim by adding more specific detail to this explanation. See lines 189-194.

Again, the overall objective in lines 171-175 was convoluted and confusing to the reader as R#2 commented, as it includes the aim and also does not speak to the aim outlined in lines 153-155-Revise. So, the authors have edited this to make sure that our overall objective links to the aim mentioned earlier in the introduction.

Additionally, the authors integrated objectives 3 and 4 into one (what are the factors that drive or limit the effectiveness of NBIs), and removed objective 5 but kept it as the ultimate goal. And, the authors provided a more concise overview on the specific objectives (lines 237—289, p.9. 4.) And the authors mentioned that the specific methodology they referring to was outlined. See lines 246-247.

Definition of “umbrella review” in lines 193-195 should come earlier in the introduction section Definition has been moved to earlier in the introduction section. See lines 200-202, p.7. 6. To answer to the R#2 statement in line 203 that sounded incomplete: “No date limit will be placed on the search until.”

This has been corrected. See line 322. 7. Justify why search will be limited to peer-reviewed studies published in English only lines 230-231- This will make you leave out articles written in other languages., the authors replied as follows:

‘’Our decision to include only peer-reviewed studies is based on our commitment to provide a synthesis of high-quality evidence which has gone through a meticulous and rigorous review process. Our decision to include only studies published in English is the result of limited resources and the language constraints of our review team. While we acknowledge that this is a limitation of our review, including studies published in Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation non-English languages would have increased resource challenges in relation to time, costs, and expertise in non-English languages.

We have clarified this in the manuscript. See lines 357-363, p.11.’’

The authors have cited the ‘definition’ in introduction section (lines 311-312) as the R#2 suggested.

Also, according to R#2 suggestion the authors removed all unnecessary repetitions.

The authors thankfully accepted the good suggestion by R#2 to consider utilizing a PRIMA flow diagram as part of methods to indicate who the selection of studies were done, and thus, the authors made their approach more evident to data selection at p.12, where they have clarified the following: “A PRISMA flow chart will be developed to record the screening and selection of studies. Once all records from our search are collected, EndNote 20 software (Thomson Reuters, Toronto, Ontario, Canada) will be used to remove duplicates and screen literature. A 2-stage screening process will be completed independently by two researchers (TS and CVYC); the first screening stage will consider titles and abstracts, while full-texts will be checked in the second stage” A completed PRISMA flow diagram has not been included in the protocol as we would not be able to populate it until screening is completed.

And, according to R#2 suggestion the authors provided adequate details on how statistical and clinical heterogeneity will be determined and how this will affect data analysis (clarified in Data Analysis section on p.18, line 556-560. Additionally, the authors have used specific software i.e. Grammarly to make changes to our grammar and language throughout the manuscript.

Finally, the bibliography:

To me the reference list remains quite updated and all the 53 citations were cited from recent literature.

However, my specific comment:

The authors must comply with checking the existing grammatical errors & spelling mistakes all through including improving the English language (better if edited by any native English-spoken person).

My last impression and final comment:

Gauging the depth of the research topic, quality of manuscript submitted (standard of research protocol: aim, objective, methodology and findings) and the outcome of the study if valuable and the avlues it might add in our scientific research bank, I do recommend that this manuscript be published in any of the recent issues of PLoS, provided all the suggested editing/corrections are reflected in the final manuscript before it is published finally.

Comment: Recommended for publication with minor revisions.

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Reviewer #2: Yes: Genesis Chorwe-Sungani

Reviewer #3: No

Reviewer #4: No

Reviewer #5: Yes: Nadia Anwar

Reviewer #6: Yes: Dr. Kazi Selim Anwar, MD, MPhil (Engand), Head, Medicl Research Unit (MRU), Ad-din Women's Medcial College, Dhaka

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Attachment

Submitted filename: Manuscript Number PONE.docx

PLoS One. 2023 Jul 21;18(7):e0273139. doi: 10.1371/journal.pone.0273139.r004

Author response to Decision Letter 1


29 Jun 2023

Response to Editor and Reviewers Comments

Dear Editor,

We would like to extend our sincerest thanks to you and the reviewers for taking the time to evaluate our revised manuscript with tracked changes and for providing us with feedback. We are grateful to you for allowing us to revise our study and incorporate these suggestions. We are now submitting our revised manuscript with tracked changes and a point-by-point response to the editor and both reviewers, which can be found below.

Reviewer #2:

The paper can be accepted for publication though responses for comment number 7 and 8 appear to be not adequate

We are unsure what the reviewer is referring to in relation to comment number 7 and 8. If the reviewer is referring to our initial response (in the first stage of review) to reviewer 2’s comments 7 and 8 we would like to expand on our previous response to explain that the focus of our review is on systematic reviews and meta-analyses including a quality assessment, which is a typical publication found among peer-reviewed publications. We would be very grateful if reviewer 2 or the academic editor could let us know what is required of us to make it adequate. Thank you for your comments we have included our initial response below for ease of remembrance:

“7. Justify why search will be limited to peer-reviewed studies published in English only-lines 230-231-This will make you leave out articles written in other languages

Our decision to include only peer-reviewed studies is based on our commitment to provide a synthesis of high-quality evidence which has gone through a meticulous and rigorous review process. Our decision to include only studies published in English is the result of limited resources and the language constraints of our review team. While we acknowledge that this is a limitation of our review, including studies published in non-English languages would have increased resource challenges in relation to time, costs, and expertise in non-English languages. We have clarified this in the manuscript.

8. Justify why unpublished grey literature will not be included in the review

This decision is linked to our aforementioned commitment to include only studies which have gone through a rigorous review process which impacts study quality. This has been clarified (Aromataris et al., 2015) https://journals.lww.com/ijebh/Fulltext/2015/09000/Summarizing_systematic_reviews__methodological.4.aspx See lines 357-363.”

Reviewer #3:

Dear Author

Thank you for the opportunity to review your manuscript again. I appreciate the efforts you have made to address the previous reviewer's comments. Overall, the manuscript is well-written, and the methodology is sound. However, I still have a few observations which are mostly positive in nature.

Firstly, I agree that an umbrella review is necessary, given the number of systematic reviews on this topic. The authors' approach of only working with systematic reviews seems to be appropriate, but I am concerned about the vastness of the topic. Please ensure that the scope of the review is clearly defined, and the search strategy is comprehensive.

We would like to thank you for recognising the need for this umbrella review. The scope of the review has been clearly defined in lines 172- 216 and the search strategy has been outlined in lines 215-248.

Secondly, I have no concerns with the methodology of the mixed-method review described in the protocol. The authors have provided sufficient explanation for the end date and English language criteria. I appreciate the thoroughness of the methodology.

Thirdly, while the introduction is well-structured and easy to follow now, I would have preferred a few examples of NBI in addition to the definition(s). This would help readers like me to better understand the concept.

We have added some examples of NBIs to the introduction as per your suggestion. See lines 81-86.

Fourthly, since most of the concerns raised by the previous reviewer have been addressed, I find the protocol to be robust. However, there is undue repetition in the 'Intervention' section. Specifically, line 312-316 and 318-321 are exact copies of line 94-98 and 100-105 from the 'Introduction' section. Please avoid such repetition and try to explain it differently in the 'Intervention' section to make it clear to the reader. By differently, I mean use the space in the intervention section to expand on what you said in the Intro section.

Thank you for highlighting this unnecessary repetition. We have removed all repetition and have changed the wording in the ‘Intervention’ section to expand on what is said in the Introduction. See lines 374-393.

In summary, the manuscript is well-written, and the methodology is sound. My observations are mostly positive, and I appreciate the authors' efforts to address the previous reviewer's comments. Please consider my feedback while revising the protocol.

Reviewer #4:

1/ good topics but its too abroad better to be restricted to specific area will be more informative 2/ if the time extended beyond that period 2022 will be better

Thanks to reviewer 4 for highlighting the merit of this review. Regarding point 1, the broad scope is coherent with the need for an overall synthesis of the available evidence and using an umbrella review demonstrates that. As mentioned in our response to our initial reviewers in the first round of review, the search will be extended beyond May 2022. In relation to point 2, no date limit will be placed on the search.

Reviewer #5:

References : some of the references are outdated . authors can chose the recent 5 years papers. 2. Authors should simply the text and focus on grammar more.

The reference list remains updated and all 53 citations were cited from recent literature.

We have simplified the text where possible and have used specific software i.e. Grammarly, Word Grammar and Spelling Editor to check the grammar of our manuscript. Additionally, all research team members have checked the manuscript for issues with grammar etc.

Reviewer #6:

Dear Editor,

Thank you for sending me a manuscript of study Protocol PONE-D-22-21700R1 for reviewing titled ‘Factors influencing the effectiveness of nature–based Interventions (NBIs) aimed at improving mental health and wellbeing: Protocol of an umbrella review’.

Since this manuscript has already been reviewed by another reviewer earlier, it was of ample advantages for me to go for reviewing for the second time.

The very title: ‘Factors influencing the effectiveness of nature–based Interventions (NBIs) aimed at improving mental health and wellbeing: Protocol of an umbrella review’ – Looks okay and self-explanatory.

To start with:

The abstract seems well described in a concise yet in a meaningful way. Alike other systematic reviews supporting NBIs as a mechanism of enhancing mental health and wellbeing, the authors claimed that available evidence for the effectiveness of NBIs remain fragmentary and mixed that yields significant fragmentation of knowledge within the field making it difficult to draw firm conclusions on an NBI.

Aim(s) and Objective(s):

The authors, aimed to study this mixed method umbrella review by synthesizing evidence on the effectiveness of NBIs as a summative review of available published systematic reviews and meta-analyses. The authors conducted a systematic search using 13 search engines, like: PsycINFO, PubMed, Greenfile, Web of Science, Embase, Scopus, Academic Search Complete (EBSCO), Environment Complete (EBSCO), Cochrane Library, CINAHL, Health Policy Reference Center and Google Scholar for a period of its inception (as the authors claimed) up to May 2022.

Methodological drives:

Strategically, the authors’ aimed to find out all (not mentioned though) published systematic reviews of NBIs yielding improved health and wellbeing as their explicit goal.

Then, for synthesis of this systematic reviews they used a mixed method (quantitative & qualitative data) engaging two independent authors who did the following steps essential for a modest review:

- Literature search,

- Record screening,

- Data extracting, and then,

- Quality assessment of each of all (not clear) systematic review and meta-analysis.

- The authors synthesized all individually qualitative & quantitative syntheses parallelly but then combined those in an overarching narrative synthesis and used the quantitative evidence to assess strength and direction of effect of NBIs on outcome of mental health and wellbeing.

Yielded results and findings:

- The authors analyzed evidences drawn from qualitative studies and synthesized to those to understand various pathways to engagement, process of involvement and experiential factors which may have mediated experiences.

- However, the authors assessed the calculated risk of bias of systematic reviews will be using a 16-item Assessment of Multiple Systematic Reviews 2 (AMSTAR2) checklist

- Finally, registered on international database of prospectively registered systematic reviews in health and social care- PROSPERO (CRD42022329179) to record & maintain that as a permanent record.

My comment on the response of authors to earlier two reviewers including reply to editor’s earlier comments, are as below:

Now, that this manuscript has been reviewed by two others including the editorial input I can guess that the state of this manuscript currently looks great as a post edited copy. However, followings remain my final comment on this pre-reviewed manuscript, par se.

Authors 1st reply to editorial review/comment earlier:

I am glad to notice that the authors revised the manuscript with point specific answers to the editor using tracked changes method.

The five Responses by the authors to each of the Academic Editor’s comments (Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corp.) remains acceptable and good to notice that accepting all the 5 comments/ queries that were raised by the editor, the authors worked on those points seriously and thus replied modestly yet logically, pointing out the corrections they made as follows:

1.The authors ensured that their manuscript met PLOS ONE's style requirements and file naming.

2.The authors agreed, attended and corrected all the error to correct those as per editor’s advices what they found during internal evaluation of the manuscript.

3.So, now it is the time for the editor to carefully review the manuscript finally that they resubmitted. But, to me it now looks okay.

4.To reply to the editor’s query to ensure by the authors that their revision is thorough so it can be acceptable in this stage, I think.

5.Regarding R-1 comment on providing repository information for author’s data, I think the authors reply is to be validated by the editor’s office yet, if it remains acceptable what the author’s pointed out on their protocol (a systematic umbrella review) may not have any empirical data to be used in preparing this manuscript, and, so the authors apologized for any errors in the data availability statement including a note on this has been reflected in their cover letter.

Next, looking at the critically raised comments by Reviewer #1 and the replies by the authors also though seems to me as acceptable but it entirely depends on R-1 and the editorial board to re-examining the authors reactions, opinions and replies, if acceptable.

However, the authors reply to this proposition that when they liked the proposed idea by R-1 of preparing two separate sister papers analyzing quantitative & qualitative evidences, separately, but explained that the scope of their review & objectives was not really the same but they had significant merit in Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation this idea provided the evidence would support such a divide. And, that the authors informed that they have completed full-text screening and on the process of developing/piloting their data extraction. By piloting the extraction sheet, they aim to gauge if there is any scope to divide the review into quantitative and qualitative evidence. However, the authors have added this stipulation to the protocol on lines 620-628, on page 19.

Moreover, to reply R-1’s concern on the scope of review being too wide by integrating objectives 3 and 4 into one …. the authors replied that they have organized the introduction to provide a clearer narrative of the study. Additionally, they have incorporated suggestions such as adding subheadings and paragraph changes. ……. However, the authors has edited (See line 249-250) and altered similar instances throughout the manuscript where the passive form is used.

In addition to the organizational points from R-1 point of view, in missing out a critical voice -there could be other reasons NBI are trending right now, e.g. that it is indeed a trend to be "natural", and that the increased interest does not in fact reflect actual effect….etc.., the authors replied that they have also provided a nuanced meta-perspective on the rise of NBIs that the R-1 suggested and they also provided a more critical perspective on NBIs. See lines 142-174, p.5.

METHODS Prisma and Prospero -good! …… The "Data collection and verification" section of the paper could be much improved by providing a visual representation (table) of the extracted data plan outlined……… … etc. The authors already refined this statement to provide more detail on our methods of synthesis for the included qualitative studies. See lines 566-568, p. 18.

On the point that R-1 raised on Ethics- the authors have added a section outlining their commitment to practice reflexivity throughout the study. And they said that they will critically examine our own role, assumptions, beliefs, pre-existing potential bias and impact on the data during all stages of the research process including: (a) formulation of the research questions, (b) data collection and (c) data analysis. Moreover, they hope that reflexive engagement by multiple analysts will enhance the quality of this research. See lines 612-618, p.19.

Thanking the Reviewer #2 for helpful and constructive feedback the authors outlined their response to R-2 comments and action taken subsequently. Moreover, as per R-2 comment the authors agreed and considered extending searches beyond May 2022.

Then, to reply to a valid point that R#2 raised on ‘Aim of the umbrella review lacks clarity in lines 153-155’ suggested for revising, the authors agreed to R-2 to clarify the aim by adding more specific detail to this explanation. See lines 189-194.

Again, the overall objective in lines 171-175 was convoluted and confusing to the reader as R#2 commented, as it includes the aim and also does not speak to the aim outlined in lines 153-155-Revise. So, the authors have edited this to make sure that our overall objective links to the aim mentioned earlier in the introduction.

Additionally, the authors integrated objectives 3 and 4 into one (what are the factors that drive or limit the effectiveness of NBIs), and removed objective 5 but kept it as the ultimate goal. And, the authors provided a more concise overview on the specific objectives (lines 237—289, p.9. 4.) And the authors mentioned that the specific methodology they referring to was outlined. See lines 246-247.

Definition of “umbrella review” in lines 193-195 should come earlier in the introduction section Definition has been moved to earlier in the introduction section. See lines 200-202, p.7. 6. To answer to the R#2 statement in line 203 that sounded incomplete: “No date limit will be placed on the search until.”

This has been corrected. See line 322. 7. Justify why search will be limited to peer-reviewed studies published in English only lines 230-231- This will make you leave out articles written in other languages., the authors replied as follows:

‘’Our decision to include only peer-reviewed studies is based on our commitment to provide a synthesis of high-quality evidence which has gone through a meticulous and rigorous review process. Our decision to include only studies published in English is the result of limited resources and the language constraints of our review team. While we acknowledge that this is a limitation of our review, including studies published in Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation non-English languages would have increased resource challenges in relation to time, costs, and expertise in non-English languages.

We have clarified this in the manuscript. See lines 357-363, p.11.’’

The authors have cited the ‘definition’ in introduction section (lines 311-312) as the R#2 suggested.

Also, according to R#2 suggestion the authors removed all unnecessary repetitions.

The authors thankfully accepted the good suggestion by R#2 to consider utilizing a PRIMA flow diagram as part of methods to indicate who the selection of studies were done, and thus, the authors made their approach more evident to data selection at p.12, where they have clarified the following: “A PRISMA flow chart will be developed to record the screening and selection of studies. Once all records from our search are collected, EndNote 20 software (Thomson Reuters, Toronto, Ontario, Canada) will be used to remove duplicates and screen literature. A 2-stage screening process will be completed independently by two researchers (TS and CVYC); the first screening stage will consider titles and abstracts, while full-texts will be checked in the second stage” A completed PRISMA flow diagram has not been included in the protocol as we would not be able to populate it until screening is completed.

And, according to R#2 suggestion the authors provided adequate details on how statistical and clinical heterogeneity will be determined and how this will affect data analysis (clarified in Data Analysis section on p.18, line 556-560. Additionally, the authors have used specific software i.e. Grammarly to make changes to our grammar and language throughout the manuscript.

We would like to thank you for taking the time to assess the revised manuscript and providing a detailed summary of the initial review process and our responses to the reviewer's suggestions.

Finally, the bibliography:

To me the reference list remains quite updated and all the 53 citations were cited from recent literature.

Thank you for acknowledging this re the bibliography.

However, my specific comment:

The authors must comply with checking the existing grammatical errors & spelling mistakes all through including improving the English language (better if edited by any native English-spoken person).

The research team (comprised of 4 individuals and 3 native English speakers) have checked existing grammatical and spelling errors. Additionally, we have used the appropriate software Grammarly to double-check these issues.

My last impression and final comment:

Gauging the depth of the research topic, quality of manuscript submitted (standard of research protocol: aim, objective, methodology and findings) and the outcome of the study if valuable and the avlues it might add in our scientific research bank, I do recommend that this manuscript be published in any of the recent issues of PLoS, provided all the suggested editing/corrections are reflected in the final manuscript before it is published finally.

Comment: Recommended for publication with minor revisions.

Thank you to the academic editor and reviewers for taking the time to look at our manuscript and providing such thorough feedback. We hope that you agree our manuscript is much improved and consider it ready for publication.

Attachment

Submitted filename: Response to Reviewers.docx

Decision Letter 2

Md Nazmul Huda

2 Jul 2023

Factors influencing the effectiveness of nature–based Interventions (NBIs) aimed at improving mental health and wellbeing: Protocol of an umbrella review

PONE-D-22-21700R2

Dear Dr. Topaz Shrestha,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

An invoice for payment will follow shortly after the formal acceptance. To ensure an efficient process, please log into Editorial Manager at http://www.editorialmanager.com/pone/, click the 'Update My Information' link at the top of the page, and double check that your user information is up-to-date. If you have any billing related questions, please contact our Author Billing department directly at authorbilling@plos.org.

If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

Kind regards,

Md. Nazmul Huda, PhD

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Dear author,

I think you addressed the comments. Therefore, we do not recommend further reviews of this manuscript. Thanks.

Nazmul

Reviewers' comments:

Acceptance letter

Md Nazmul Huda

12 Jul 2023

PONE-D-22-21700R2

Factors influencing the effectiveness of Nature-based Interventions (NBIs) aimed at improving mental health and wellbeing: Protocol of an umbrella review

Dear Dr. Shrestha:

I'm pleased to inform you that your manuscript has been deemed suitable for publication in PLOS ONE. Congratulations! Your manuscript is now with our production department.

If your institution or institutions have a press office, please let them know about your upcoming paper now to help maximize its impact. If they'll be preparing press materials, please inform our press team within the next 48 hours. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information please contact onepress@plos.org.

If we can help with anything else, please email us at plosone@plos.org.

Thank you for submitting your work to PLOS ONE and supporting open access.

Kind regards,

PLOS ONE Editorial Office Staff

on behalf of

Dr. Md. Nazmul Huda

Academic Editor

PLOS ONE

Associated Data

    This section collects any data citations, data availability statements, or supplementary materials included in this article.

    Supplementary Materials

    S1 Table. PRISMA-P checklist.

    (DOC)

    S2 Table. Search strategy.

    (DOCX)

    Attachment

    Submitted filename: PLOS ONE Review.docx

    Attachment

    Submitted filename: Response to Reviewers.docx

    Attachment

    Submitted filename: Manuscript Number PONE.docx

    Attachment

    Submitted filename: Response to Reviewers.docx

    Data Availability Statement

    This is a protocol for a systematic umbrella review, thus no empirical data has been collected to prepare this manuscript. No datasets were generated or analysed during the current study.


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