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. 2023 Jun 11;31(7):2297. doi: 10.1016/j.ymthe.2023.06.001

A trans-amplifying RNA simplified to essential elements is highly replicative and robustly immunogenic in mice

Mario Perkovic, Stefanie Gawletta, Tina Hempel, Silke Brill, Evelin Nett, Ugur Sahin , Tim Beissert ∗∗
PMCID: PMC10362407  PMID: 37307814

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(Molecular Therapy 31, 1636–1646; June 2023)

In the originally published version of this article, a number of transreplicon sequences provided in Table S1 were misspelled. During the revision and publication process, one superfluous and potentially harmful “G” was added unintentionally downstream to the first transcribed nucleotide following the T7 polymerase promoter. Upon in vitro transcription, resulting transcripts would start with 5’-GGAU…-3’. This erroneous extension of the 5’end could affect replication. The correct 5’end should be 5’-GAU…-3’.

This has been corrected online, and the authors apologize for this error.

Contributor Information

Ugur Sahin, Email: ugur.sahin@biontech.de.

Tim Beissert, Email: tim.beissert@tron-mainz.de.


Articles from Molecular Therapy are provided here courtesy of The American Society of Gene & Cell Therapy

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