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. 2023 Jun 8;93:104590. doi: 10.1016/j.ebiom.2023.104590

Table 1.

Median observed VRC01 bnAb concentrations among recipients without HIV-1 by dosing regimen and by trial.

AMP trial Median VRC01 serum concentration
10 mg/kg 30 mg/kg VRC01 pooled
HVTN 704/HPTN 085 9.3 mg/ml (n = 19) 28.4 mg/ml (n = 21) 18.7 mg/ml
HVTN 703/HPTN 081 12.2 mg/ml (n = 21) 32.1 mg/ml (n = 21) 20.5 mg/ml
Pooled 10.1 mg/ml 31.0 mg/ml 19.6 mg/ml

The values are calculated from the subset of case-control data set for VRC01 recipients without HIV-1, as medians of participant-specific medians over all mid-infusion visits through to the week 76 visit (n=82).

The number of recipients without HIV-1 included in subsequent analyses is listed in parentheses for each group.