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. 2016 Mar 1;99(1):83–91. doi: 10.3184/003685016X14495646283298

Rosemary, the Beneficial Chemistry of a Garden Herb

James R Hanson 1,✉
PMCID: PMC10365379  PMID: 27120816

Abstract

The major natural products that are present in the garden herb, rosemary (Rosmarinus officinalis) including the mono di- and triterpenoid, flavonoid and phenolic constituents together with their biological activity as anti-microbial, anti-oxidant, anti-inflammatory, memory-enhancing and tumour-inhibitory agents, are reviewed.

Keywords: Rosmarinus officinalis, cineole, carnosol, rosmarinic acid, anti-oxidant

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References

  • 1.Grieve M. (1931) In: Lloyd C.F. (ed.), A modern herbal, pp. 681–683. Jonathan Cape, London: (Penguin Books, London, 1976). [Google Scholar]
  • 2.Lawless J. (1992) The encylopedia of essential oils, pp. 180–181. Element Press, Shaftesbury. [Google Scholar]
  • 3.Usher G. (1974) A dictionary of plants used by man, p. 510. Constable, London. [Google Scholar]
  • 4.Sell C.S. (2003) A fragrant introduction to terpenoid chemistry. Royal Society’ of Chemistry, Cambridge. [Google Scholar]
  • 5.Amin T., Sharma N., and Bhat S.V. (2012) Med. Plants, 4, 177–181. [Google Scholar]
  • 6.Flamini G., Cioni P.L., Morelli I. et al. (2002) J. Agric. Food Chem., 50, 3512–3517. [DOI] [PubMed] [Google Scholar]
  • 7.Jordan M.J., Lax V., Martinez C. et al. (2011) Acta Horticul., 925, 109–114. [Google Scholar]
  • 8.Lakusic D.V., Ristic M.S., Slavkovska V.N. et al. (2012) Chem. Biodivers., 9, 1286–1302. [DOI] [PubMed] [Google Scholar]
  • 9.Haini K., Sotomayor J.A., Jordan M.J., and Bouzid S. (2013) Asian J. Chem., 25, 2601–2603. [Google Scholar]
  • 10.Ben Jemia M., Tundis R., Pugliesi A. et al. (2015) Nat. Prod. Res., 29, 213–222. [DOI] [PubMed] [Google Scholar]
  • 11.Achilladelis B., and Hanson J.R. (1968) Phytochemistry, 7, 1317–1319. [Google Scholar]
  • 12.Banthorpe D.V., Christou P.N., Pink C.R., and Watson D.G. (1983) Phytochemistry, 22, 2465–2468. [Google Scholar]
  • 13.Webb J.K., Banthorpe D.V., and Watson D.G. (1984) Phytochemistry, 23, 903–904. [Google Scholar]
  • 14.Rieder C., Jaun B., and Arigoni D. (2000) Helv. Chim. Acta, 83, 2504–2513. [Google Scholar]
  • 15.Wise M.L., Urbansky M., Helms G.L., Coates R.M., and Croteau R. (2002) J. Am. Chem. Soc., 124, 8546–8547. [DOI] [PubMed] [Google Scholar]
  • 16.Peters R.J., and Croteau R.B. (2003) Arch. Biochem. Biophys., 417, 203–211. [DOI] [PubMed] [Google Scholar]
  • 17.Weyerstahl P., and Krohn K. (1990) Tetrahedron, 46, 3503–3514. [Google Scholar]
  • 18.Brieskorn C.H., and Beck K.R. (1910) Phytochemistry, 9, 1633–1640. [Google Scholar]
  • 19.White A.I., and Jenkins G.L. (1942) J. Am. Pharm. Assoc., 31, 33–37. [Google Scholar]
  • 20.Brieskorn C.H., and Fuchs A. (1962) Chem. Ber., 95, 3034–3041. [Google Scholar]
  • 21.Brieskorn C.H., Fuchs A., Bredenberg J.B. et al. (1964) J. Org. Chem., 29, 2293–2298. [Google Scholar]
  • 22.Wenkert E., Fuchs A., and McChesney J.D. (1965) J. Org. Chem., 30, 2931–2934. [Google Scholar]
  • 23.Inatani R., Nakatani N., Fuwa H., and Seto H. (1982) Agric. Biol. Chem., 46, 1661–1666. [Google Scholar]
  • 24.Fraga B.M., Gonzalez A.G., Herrera J.R. et al. (1985) Phytochemistry, 24, 1853–1854. [Google Scholar]
  • 25.Oluwatuyi M., Kaatz G.W., and Gibbons S. (2004) Phytochemistry, 65, 3249–3254. [DOI] [PubMed] [Google Scholar]
  • 26.Cantrell C.L., Richheimer S.L., Nicholas G.M. et al. (2005) J. Nat. Prod., 68, 98–100. [DOI] [PubMed] [Google Scholar]
  • 27.Mahmoud A.A., Al-Shihry S.S., and Son B.W. (2005) Phytochemistry, 66, 1685–1690. [DOI] [PubMed] [Google Scholar]
  • 28.Cui L., Kim M.O., Seo J.H. et al. (2012) Food. Chem., 132, 1775–1780. [Google Scholar]
  • 29.Munoz M.A., Perez-Hernandez N., Pertino M.W,et al. (2012) J. Nat. Prod., 75, 779–783. [DOI] [PubMed] [Google Scholar]
  • 30.Richheimer S.L., Bernart M.W., King G.A. et al. (1996) J. Am. Oil. Chem. Soc., 73, 507. [Google Scholar]
  • 31.Hidalgo P.J., Ubera J.L., Tena M.T., and Valcarcel M. (1998) J. Agric. Food Chem., 46, 2624–2647. [Google Scholar]
  • 32.Bicchi C., Binelio A., and Rubiolo P. (2000) Phytochem. Anal., 11, 236–242. [Google Scholar]
  • 33.Wellwood C.R.L., and Cole R.A. (2004) J. Agric. Food Chem., 52, 6101–6107. [DOI] [PubMed] [Google Scholar]
  • 34.Masuda T., Inaba Y., and Takeda Y. (2001) J. Agric. Food Chem., 49, 5560–5565. [DOI] [PubMed] [Google Scholar]
  • 35.Zhang Y., Smuts J.P., Dodhiba E. et al. (2012) J. Agric. Food Chem., 60, 9305–9314. [DOI] [PubMed] [Google Scholar]
  • 36.Peters R.J. (2010) Nat. Prod. Rep., 27, 1521–1538. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 37.Bruckner K., Bozic D., Manzano D. et al. (2014) Phytochemistry, 101, 52–64. [DOI] [PubMed] [Google Scholar]
  • 38.Ganeva Y., Tsankova E., Simova S. et al. (1993) Planta Med., 59, 276–277. [DOI] [PubMed] [Google Scholar]
  • 39.Aitinier G., Sosa S., Aquino R.P. et al. (2007) J. Agric. Chem. Soc., 55, 1718–1723. [DOI] [PubMed] [Google Scholar]
  • 40.Huang M.T., Ho C.T., Wang Z.Y. et al. (1994) Cancer Res., 54, 701–708. [PubMed] [Google Scholar]
  • 41.Okamura N., Haraguchi H., Hashimoto K., and Yagi A. (1994) Phytochemistry, 37, 1463–1466. [DOI] [PubMed] [Google Scholar]
  • 42.Del Bano M.J., Lorente J., Castillo J. et al. (2003) J. Agric. Food Chem., 51, 4247–4253. [DOI] [PubMed] [Google Scholar]
  • 43.Del Bano M.J., Lorente J., Castillo J. et al. (2004) J. Agric. Food Chem., 52, 4987–4992. [DOI] [PubMed] [Google Scholar]
  • 44.Bai M., He K., Roller M. et al. (2010) J. Agric. Food Chem., 58, 5363–5367. [DOI] [PubMed] [Google Scholar]
  • 45.Petersen M., and Simmonds M.S.J. (2003) Phytochemistry, 62, 121–125. [DOI] [PubMed] [Google Scholar]
  • 46.Grayer R.J., Eckert M.R., Veitch N.C. et al. (2003) Phytochemistry, 64, 519–528. [DOI] [PubMed] [Google Scholar]
  • 47.Frankel E.N., Huang S-W, Aeschbach R., and Prior E. (1996) J. Agric. Food Chem., 44, 131–135. [Google Scholar]
  • 48.Angioni A., Barra A., Cereti E. et al. (2004) J. Agric. Food Chem., 52, 2530–3535. [DOI] [PubMed] [Google Scholar]
  • 49.Lopez P., Sanchez C., Batlle R., and Nerin C. (2005) J. Agric. Food Chem., 53, 5939–5946. [DOI] [PubMed] [Google Scholar]
  • 50.Jordan M.J., Lax V., Rota M.C., Loran S., and Sotomayor J.A. (2012) J. Agric. Food Chem., 60, 9603–9608. [DOI] [PubMed] [Google Scholar]
  • 51.Kontogianni V.G., Tomic G., Nikolic I. et al. (2013) Food Chem., 136, 120–129. [DOI] [PubMed] [Google Scholar]
  • 52.Wang W., Li N., Luo M., Zu Y., and Efferth T.E. (2012) Molecules, 17, 2704–2713. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 53.Bernardes W.A., Lucarini R., Tozatti M.G. et al. (2010) Chem. Biodivers., 7, 1835–1840. [DOI] [PubMed] [Google Scholar]
  • 54.Jordan M.J., Castillo J., Banon S. et al. (2014) Food Chem., 151, 212–218. [DOI] [PubMed] [Google Scholar]
  • 55.Wijeratne S.S.K., and Coppett S.L. (2007) J. Agric. Food Chem., 55, 1193–1199. [DOI] [PubMed] [Google Scholar]
  • 56.Perlino M.W., Theoduloz C., Rodriguez J.A. et al. (2010) J. Nat. Prod., 73, 639–643. [DOI] [PubMed] [Google Scholar]
  • 57.Beninca J.P., Dalmarco J.B., Pizzolatti M.G., and Frode T.S. (2011) Food Chem., 124, 468–475. [Google Scholar]
  • 58.Moss L., Rouse M., Wesnes K., and Moss M. (2010) Hum. Psychopharmacol. Clin. Exp., 25, 388–396. [DOI] [PubMed] [Google Scholar]
  • 59.Machado D.G., Gunha M.P., Neis V.B. et al. (2013) Food Chem., 136, 999–1005. [DOI] [PubMed] [Google Scholar]
  • 60.Orhan I., Asian S., Kartal M. et al. (2008) Food Chem., 108, 663–668. [DOI] [PubMed] [Google Scholar]
  • 61.Romagni J.G., Allen S.N., and Dayan F.E. (2000) J. Chem. Ecol., 26, 303–313. [Google Scholar]
  • 62.Angelini L.G., Carpanese G., Cioni P.L. et al. (2003) J. Agric. Food Chem., 51, 6158–6164. [DOI] [PubMed] [Google Scholar]
  • 63.Katerinopoulos H.E., Pagona G., Afralis A. et al. (2005) J. Chem. Ecol., 31, 111–122. [DOI] [PubMed] [Google Scholar]
  • 64.Maggi M., Gende L., Russo K. et al. (2011) Nat. Prod. Res., 25, 397–408. [DOI] [PubMed] [Google Scholar]

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