Beyond the Discovery Void: New Targets for Antibacterial Compounds

Claire E Broughton; Hugo A Van Den Berg; Alan M Wemyss; David I Roper; Alison Rodger

doi:10.3184/003685016X14616130512308

. 2016 Jun 2;99(2):153–182. doi: 10.3184/003685016X14616130512308

Beyond the Discovery Void: New Targets for Antibacterial Compounds

Claire E Broughton ^1,^✉, Hugo A Van Den Berg ¹, Alan M Wemyss ², David I Roper ¹, Alison Rodger ¹

PMCID: PMC10365418 PMID: 28742471

Abstract

Antibiotics save many lives, but their efficacy is under threat: overprescription, population growth, and global travel all contribute to the rapid origination and spread of resistant strains. Exacerbating this threat is the fact that no new major classes of antibiotics have been discovered in the last 30 years: this is the “discovery void.” We discuss the traditional molecular targets of antibiotics as well as putative novel targets.

Keywords: antibiotics, bacterial resistances to antibiotics, MRSA, discovery void, cell wall, cell division

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Beyond the Discovery Void: New Targets for Antibacterial Compounds

Claire E Broughton

Hugo A Van Den Berg

Alan M Wemyss

David I Roper

Alison Rodger

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Beyond the Discovery Void: New Targets for Antibacterial Compounds

Claire E Broughton

Hugo A Van Den Berg

Alan M Wemyss

David I Roper

Alison Rodger

Abstract

Full Text

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