Modulating the Human Gut Microbiome as an Emerging Therapeutic Paradigm

Deepak K Rajpal; James R Brown

doi:10.3184/003685013X13691404141587

. 2013 Sep 1;96(3):224–236. doi: 10.3184/003685013X13691404141587

Modulating the Human Gut Microbiome as an Emerging Therapeutic Paradigm

Deepak K Rajpal ^a, James R Brown ^b,^*

PMCID: PMC10365493 PMID: 24244970

Abstract

The human body is actually a vast and changing ecosystem comprised of billions of microbial organisms, known collectively as the microbiome. Within the last few years, the study of the microbiome and its impact on human health has been a rapidly growing area of biomedical science. The gut intestinal tract microbiome has been a particular focus of research given its potential role in many inflammatory and metabolic diseases as well as drug metabolism. Although a nascent field, the potential for modulating the gut microbiome or human host interactions associated with these microbes offers new therapeutic strategies for many chronic diseases, in particular obesity, diabetes and inflammatory bowel diseases. Here we provide an overview of present knowledge about the gut microbiome, its putative role in metabolic diseases and the potential for microbiome focused treatments from the drug development perspective.

Keywords: microbiome, metabolic disease, obesity, diabetes, drug discovery, human genome

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Modulating the Human Gut Microbiome as an Emerging Therapeutic Paradigm

Deepak K Rajpal

James R Brown

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Modulating the Human Gut Microbiome as an Emerging Therapeutic Paradigm

Deepak K Rajpal

James R Brown

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