Bacteriophage Endolysins and their Applications

Jude Ajuebor; Olivia McAuliffe; Jim O'Mahony; R Paul Ross; Colin Hill; Aidan Coffey

doi:10.3184/003685016X14627913637705

. 2016 Jun 2;99(2):183–199. doi: 10.3184/003685016X14627913637705

Bacteriophage Endolysins and their Applications

Jude Ajuebor ^1,^✉, Olivia McAuliffe ^2,^✉, Jim O'Mahony ^3,^✉, R Paul Ross ^4,^✉, Colin Hill ^5,^✉, Aidan Coffey ^6,^✉

¹Cork Institute of Technology (CIT).

²Teagasc Food Research Centre, Moorepark, County Cork, Ireland.

³Cork Institute of Technology (CIT) at the Department of Biological Sciences.

⁴Dean of the College of Science Engineering and Food Science at University College Cork.

⁵University College Cork and a Principal Investigator in the Alimentary Pharmabiotic Centre.

⁶Cork Institute of Technology at the Department of Biological Sciences and Head of the BioExplore Research Centre.

^✉

jude.ajuebor@mycit.ie.

^✉

olivia.mcauliffe@teagasc.ie.

^✉

jim.omahony@cit.ie.

^✉

p.ross@ucc.ie.

^✉

c.hill@ucc.ie.

^✉

aidan.coffey@cit.ie.

His research focuses on the exploitation of bacteriophages and their endolysins for the elimination of pathogenic bacteria with particular emphasis on Clostridium difficile and Staphylococcus aureus. He also completed his undergraduate degree at CIT.

She is a graduate of University College Cork where she obtained her PhD in 1999. Her current research programme focuses on bacteriophages and the relationship that they have with their host cells, particularly bacteriophages infecting starter cultures used for the production of fermented foods.

He graduated with a MSc from University College Cork in 1994 and a PhD in 1999, and has held a number of senior research positions at the Microbiology Department and the Alimentary Pharmabiotic Centre in University College Cork prior to moving to CIT in 2005.

He is also a Principal Investigator in the Alimentary Pharmabiotic Centre. He graduated from University College Cork with a BSc in Microbiology/Biochemistry in 1984 and with a PhD in Microbiology in 1989. He was awarded a DSc in 2009 by the National University of Ireland based on his published works and was elected to the Royal Irish Academy in 2010.

He graduated from University College Cork with a MSc in Biotechnology in 1984 and with PhD in 1988 and was awarded a DSc in 2005 by the National University of Ireland in recognition of his contributions to research. He was elected to the Royal Irish Academy in 2009.

His research focuses on antimicrobials with particular emphasis on bacteriophages. He received his PhD in Microbiology from University College Cork in 1991 and subsequently worked for three years at Bioresearch Ireland, followed by Wageningen Agricultural University (Netherlands), and Teagasc Food Research Centre before moving to Cork Institute of Technology in 2002.

PMCID: PMC10365499 PMID: 28742472

Abstract

Endolysins (lysins) are bacteriophage-encoded enzymes that have evolved to degrade specific bonds within the bacterial cell wall. These enzymes represent a novel class of antibacterial agents against infectious pathogens, especially in light of multidrug-resistant bacteria, which have made antibiotic therapy increasingly redundant. Lysins have been used successfully to eliminate/control bacterial pathogens in various anatomical locations in mouse and other animal models. Engineering tactics have also been successfully applied to improve lysin function. This review discusses the structure and function of lysins. It highlights protein-engineering tactics utilised to improve lysin activity. It also reviews the applications of lysins towards food biopreservation, therapeutics, bioifilm elimination and diagnostics.

Keywords: antibacterial, bacteriophage, detection, endolysin, lysis, protein engineering

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[bibr7-003685016X14627913637705] 7.Oliveira H., Thiagarajan V., Walmagh M. et al. (2014) PLoS One, 9, e108376. [DOI] [PMC free article] [PubMed] [Google Scholar]

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[bibr11-003685016X14627913637705] 11.Rodríguez-Rubio L., Martínez B., Rodríguez A. et al. (2013) PLoS One, 8, 1–7. [DOI] [PMC free article] [PubMed] [Google Scholar]

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[bibr14-003685016X14627913637705] 14.Gaeng S., Scherer S., Neve H., and Loessner M.J. (2000) Appl. Environ. Microb., 66, 2951–2958. [DOI] [PMC free article] [PubMed] [Google Scholar]

[bibr15-003685016X14627913637705] 15.Mayer M.J., Narbad A., and Gasson M.J. (2008) J. Bacteriol., 190, 6734–6740. [DOI] [PMC free article] [PubMed] [Google Scholar]

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Bacteriophage Endolysins and their Applications

Jude Ajuebor

Olivia McAuliffe

Jim O'Mahony

R Paul Ross

Colin Hill

Aidan Coffey

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Bacteriophage Endolysins and their Applications

Jude Ajuebor

Olivia McAuliffe

Jim O'Mahony

R Paul Ross

Colin Hill

Aidan Coffey

Abstract

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