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. 2019 Feb 27;97(1):1–19. doi: 10.3184/003685014X13898980185076

Metal-based Drugs

Ruth J Mcquitty 1,✉
PMCID: PMC10365534  PMID: 24800466

Abstract

Metals have been considered for millennia to have medicinal values. With the advent of modern medicine, many metal-based drugs have proven to be highly effective in the clinic. Many different metal ions have shown activity against a range of diseases. The unique electronic structure of transition metals offers great versatility, not always seen in organic drugs, in terms of the ability to tune the properties of a given molecule. This review gives a brief overview of the most established therapeutic metals, and their more common applications, such as platinum-based anticancer drugs. New developments within the field of metallodrugs and novel strategies being employed to improve methods of delivery, are also discussed.

Keywords: metals in medicine, metallodrugs, metal-based drugs, drug delivery, targeting, photoactivation, photonic crystal fibres

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