Abstract
The guts of people and animals function like industrial chemical plants. They are assemblies of tubes and tanks in which foods are hydrolysed by enzyme-catalysed reactions, or fermented by microorganisms. Raw materials enter at one end, waste matter is voided at the other, and valuable products are abstracted on the way. A mill at the entrance end reduces the raw materials to small fragments, enabling the reactions to proceed faster. This paper shows how ideas from chemical engineering are guiding research on the gut, giving much clearer understanding of how foods respond to chewing, and of how guts are designed to process different foods. We will discuss the teeth as a grinding mill, and the digestive tube as a chain of chemical reactors.
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References
- 1.McCabe W. L., Smith J. C. & Harriott P. (1993) Unit Operations of Chemical Engineering, 5th edn McGraw-Hill, New York. [Google Scholar]
- 2.Lucas P. W. & Luke D. A. (1983) Methods for analysing the breakdown of foods in human mastcation. Archs Oral Biol. 28, 813–820. [DOI] [PubMed] [Google Scholar]
- 3.Agrawal K. R., Lucas P. W., Prinz J. F. & Bruce I. C. (1997) Mechanical properties of foods responsible for resisting food breakdown in the human mouth. Archs Oral Biol., 42, 1–9. [DOI] [PubMed] [Google Scholar]
- 4.Blaxter K. L. (1989) Energy Metabolism in Animals and Man. Cambridge University Press. [Google Scholar]
- 5.Prinz J. F. & Lucas P. W. (1997) An optimization model for mastication and swallowing in mammals. Proc. Roy. Soc., B 264, 1715–1721. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 6.Penry D. L. & Jumars P. A. (1987) Modeling animal guts as chemical reactors. Am. Nat. 129, 69–96. [Google Scholar]
- 7.Bailey J. E. & Ollis D. F. (1986) Biochemical Engineering Fundamentals, 2nd edn. McGraw-Hill, New York. [Google Scholar]
- 8.Alexander R. McN. (1991) Optimization of gut structure and diet for higher vertebrate herbivores. Phil. Trans. Roy. Soc. B 333, 249–255. [DOI] [PubMed] [Google Scholar]
- 9.Alexander R. McN. (1993) The relative merits of foregut and hindgut fermentation. J. Zool. 231, 391–401. [Google Scholar]
- 10.Chivers D. J. & Hladik C. M. (1980) Morphology of the gastrointestinal tract in primates: comparisons with other mammals in relation to diet. J. Morphol. 166, 337–386. [DOI] [PubMed] [Google Scholar]
- 11.Maloiy G. M. O., Clemens E. T. & Kamau J. M. Z. (1982) Aspects of digestion and in vitro fermentation rate in six species of East African wild ruminants. J. Zool., 197, 345–353. [Google Scholar]
- 12.Dade W. B., Jumars P. A. & Penry D. L. (1990) Supply-side optimization: maximizing absorbtive rates. In: Hughes R. N. (ed.) Behavioural Mechanisms of Food Selection, pp.531–556. Springer, London. [Google Scholar]
- 13.Diamond J. & Hammond K. (1992) The matches, achieved by natural selection, between biological capacities and their natural loads. Experientia, 48, 551–557. [DOI] [PubMed] [Google Scholar]
- 14.Weiss S. L., Lee E. A. & Diamond J. (1998) Evolutionary matches of enzyme and transporter capacities to dietary substrate loads in the intestinal brush border. Proc. Nat. Acad. Sci., 95, 2117–2121. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 15.Alexander R. McN. (1997) A theory of mixed chains applied to safety factors in biological systems. J. Theor. Biol., 184, 247–252. [DOI] [PubMed] [Google Scholar]
- 16.Backhurst J. R. & Harker J. H. (1973) Process Plant Design. Heinemann, London. [Google Scholar]
- 17.Gordon I. J. & Illius A. W. (1996) The nutritional ecology of African ruminants: a reinterpretation. J. Anim. Ecol., 65, 18–28. [Google Scholar]
- 18.Illius A. W. & Gordon I. J. (1992) Modelling the nutritional ecology of ungulate herbivores: evolution of body size and competitive interactions. Oecologia, 89, 428–434. [DOI] [PubMed] [Google Scholar]
- 19.Belovsky G. E. (1997) Optimal foraging and community structure: the allometry of herbivore food selection and competition. Evolut. Ecol., 11, 641–672. [Google Scholar]
- 20.Schmidt-Nielsen K. (1990) Animal Physiology: Adaptation and Environment, 4th edn. Cambridge University Press. [Google Scholar]
