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. 2008 Mar 1;91(1):1–37. doi: 10.3184/003685008X284628

The Epidemiological Transition: The Current Status of Infectious Diseases in the Developed World versus the Developing World

John W Sanders 1,✉, Greg S Fuhrer 2, Mark D Johnson 3, Mark S Riddle 4
PMCID: PMC10367498  PMID: 18453281

Abstract

Wealthy, industrialized countries of the developed world successfully underwent the “epidemiologic transition “ from infectious diseases to degenerative diseases, but developing countries have not yet achieved that transition. This article reviews the current status of Omran's Theory of Epidemiologic Transition, comparing the burden of infectious diseases in the developed world versus the developing world. The advent of modern sanitation and hygiene practices, effective vaccines, and antibiotics have significantly diminished the burden in the developed world, but infectious diseases remain the most common cause of death worldwide. The persistence of this disease burden has been due to a failure to employee effective strategies and to unforeseen developments, such as the emergence of HIV and the re-emergence of malaria and tuberculosis driven by newly developed drug resistance. The challenge in accurately assessing infectious disease burden and developing effective interventions is reviewed along with the most common diseases and current intervention strategies.

Keywords: epidemiology, epidemiologic transition, infectious disease, developing world, developed world, HIV, malaria, tuberculosis, diarrhea, tropical disease

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References

  • 1.Armstrong G.L., Conn L.A., and Pinner R.W. (1999) Trends in infectious disease mortality in the United States during the 20th century. JAMA, 281, 61–66. [DOI] [PubMed] [Google Scholar]
  • 2.Taylor R., Lewis M., and Powles J. (1998) The Australian mortality decline: all-cause mortality 1788–1990. Aust. N.Z. J. Public Hlth., 22, 27–36. [DOI] [PubMed] [Google Scholar]
  • 3.Wolleswinkel-van den Bosch J.H., Looman C.W., Van Poppel F.W., and Mackenbach J.P. (1997) Cause-specific mortality trends in The Netherlands, 1875–1992: a formal analysis of the epidemiologic transition. Int. J. Epidemiol., 26, 772–781. [DOI] [PubMed] [Google Scholar]
  • 4.De Flora S., Quaglia A., Bennicelli C., and Vercelli M. (2005) The epidemiological revolution of the 20th century. Faseb. J., 19, 892–897. [DOI] [PubMed] [Google Scholar]
  • 5.Historian, T.O. o.t. P.H.S. accessed on May 28, 2007 at (http://lhncbc.nlm.nih.-gov/apdb/phsHistory/faqs.html).
  • 6.Sassetti C.M., and Rubin E.J. (2007) The open book of infectious diseases. Nat. Med., 13, 279–280. [DOI] [PubMed] [Google Scholar]
  • 7.Morens D.M., Folkers G.K., and Fauci A.S. (2004) The challenge of emerging and re-emerging infectious diseases. Nature, 430, 242–249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8.WHO. (2002) Reducing Risks, Promoting Healthy Life. World Health Report. [DOI] [PubMed]
  • 9.Mathers C.D., and Loncar D. (2006) Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med., 3, e442. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 10.Pinner R.W., Teutsch S.M., Simonsen L., Klug L.A., Graber J.M., Clarke M.J., and Berkelman R.L. (1996). Trends in infectious diseases mortality in the United States. JAMA, 275, 189–193. [PubMed] [Google Scholar]
  • 11.Omran A.R. (1971) The epidemiologic transition. A theory of the epidemiology of population change. Milbank Mem. Fund Q., 49, 509–538. [PubMed] [Google Scholar]
  • 12.Vaccine preventable deaths and the Global Immunization Vision and Strategy, 2006–2015. (2006) MMWR Morb Mortal. Wkly. Rep., 55, 511–515. [PubMed] [Google Scholar]
  • 13.UNAIDS. UNAIDS, Accessed on May 20, 2007 at (http://www.unaids.org/en/HIV_data/2006GlobalReport/default.asp).
  • 14.Fauci A.S. (2005) Emerging and reemerging infectious diseases: the perpetual challenge. Acad. Med., 80, 1079–1085. [DOI] [PubMed] [Google Scholar]
  • 15.Lashley F.R. (2006) Emerging infectious diseases at the beginning of the 21st century. Online J. Issues Nurs., 11, 2. [PubMed] [Google Scholar]
  • 16.Fauci A.S. (2006) Emerging and re-emerging infectious diseases: influenza as a prototype of the host-pathogen balancing act. Cell., 124, 665–670. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17.Walensky R.P., Paltiel A.D., Losina E., Mercincavage L.M., Schackman B.R., Sax P.E., Weinstein M.C., and Freedberg K.A. (2006) The survival benefits of AIDS treatment in the United States. J. Infect. Dis., 194, 11–19. Epub. 2006 Jun 1. [DOI] [PubMed] [Google Scholar]
  • 18.Smit C., Geskus R., Uitenbroek D., Mulder D., Van Den Hoek A., Coutinho R.A., and Prins M. (2004) Declining AIDS mortality in Amsterdam: contributions of declining HIV incidence and effective therapy. Epidemiology, 15, 536–542. [DOI] [PubMed] [Google Scholar]
  • 19.Dorling D., Shaw M., and Davey Smith G. (2006) Global inequality of life expectancy due to AIDS. BMJ, 332, 662–664. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 20.Fischer T.K., Viboud C., Parashar U., Malek M., Steiner C., Glass R., and Simonsen L. (2007) Hospitalizations and deaths from diarrhea and rotavirus among children <5 years of age in the United States, 1993–2003. J. Infect. Dis., 195, 1117–1125. Epub. 2007 Mar 6. [DOI] [PubMed] [Google Scholar]
  • 21.Soriano-Gabarro M., Mrukowicz J., Vesikari T., and Verstraeten T. (2006) Burden of rotavirus disease in European Union countries. Pediatr. Infect. Dis. J., 25, S7–S11. [DOI] [PubMed] [Google Scholar]
  • 22.Stebbins S. (2007) Rotavirus: Disease and vaccine update, 2007. J. Fam. Pract., 56, S6–S11. [PubMed] [Google Scholar]
  • 23.Glass R.I., Bresee J.S., Turcios R., Fischer T.K., Parashar U.D., and Steele A.D. (2005) Rotavirus vaccines: targeting the developing world. J. Infect. Dis., 192 Suppl. 1, S160–166. [DOI] [PubMed] [Google Scholar]
  • 24.Agosti J.M., and Goldie S.J. (2007) Introducing HPV vaccine in developing countries-key challenges and issues. N. Engl. J. Med., 356, 1908–1910. [DOI] [PubMed] [Google Scholar]
  • 25.Kane M.A., Sherris J., Coursaget P., Aguado T., and Cutts F. (2006) Chapter 15: HPV vaccine use in the developing world. Vaccine, 24 Suppl. 3, S132–139. [DOI] [PubMed] [Google Scholar]
  • 26.Twombly R. (2006) U.S. girls to receive HPV vaccine but picture unclear on potential worldwide use, acceptance. J. Natl. Cancer Inst., 98, 1030–1032. [DOI] [PubMed] [Google Scholar]
  • 27.Wittet S. (2000) Introducing GAVI and the Global Fund for Children's Vaccines. Vaccine, 19, 385–386. [DOI] [PubMed] [Google Scholar]
  • 28.Walgate R. (2002) Global Fund for AIDS, TB and malaria opens shop. Bull. World Health Organ., 80, 259. [PMC free article] [PubMed] [Google Scholar]
  • 29.PEPFAR and the fight against HIV/AIDS. (2007) lancet, 369, 1141. [DOI] [PubMed] [Google Scholar]
  • 30.Drager S., Gedik G., and Dal Poz M.R. (2006) Health workforce issues and the Global Fund to fight AIDS, Tuberculosis and Malaria: an analytical review. Hum. Resour Health, 4, 23. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 31.Nossal G.J. (2003) Gates, GAVI, the glorious global funds and more: all you ever wanted to know. Immunol. Cell. Biol., 81, 20–22. [DOI] [PubMed] [Google Scholar]
  • 32.Control of infectious diseases. (1999) MMWR Morb. Mortal. Wkly. Rep., 48, 621–9. [PubMed] [Google Scholar]
  • 33.Cutler D., and Miller G. (2005) The role of public health improvements in health advances: the twentieth-century United States. Demography, 42, 1–22. [DOI] [PubMed] [Google Scholar]
  • 34.Burns H. (2007) Germ theory: invisible killers revealed. BMJ, 334 Suppl. 1, s11. [DOI] [PubMed] [Google Scholar]
  • 35.Plane D.A., Henrie C.J., and Perry M.J. (2005) Migration up and down the urban hierarchy and across the life course. Proc. Natl. Acad. Sci. U.S.A., 102, 15313–15318. Epub. 2005 Oct. 17. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 36.Budnik A., and Liczbinska G. (2006) Urban and rural differences in mortality and causes of death in historical Poland. Am. J. Phys. Anthropol., 129, 294–304. [DOI] [PubMed] [Google Scholar]
  • 37.Freudenberg N., Galea S., and Vlahov D. (2005) Beyond urban penalty and urban sprawl: back to living conditions as the focus of urban health. J. Community Health, 30, 1–11. [DOI] [PubMed] [Google Scholar]
  • 38.Vlahov D., Galea S., Gibble E., and Freudenberg N. (2005) Perspectives on urban conditions and population health. Cad. Saude Publica., 21, 949–957. Epub. 2005 May 2. [DOI] [PubMed] [Google Scholar]
  • 39.Vlahov D., Gibble E., Freudenberg N., and Galea S. (2004) Cities and health: history, approaches, and key questions. Acad. Med., 79, 1133–1138. [DOI] [PubMed] [Google Scholar]
  • 40.Stern A.M., and Markel H. (2004) International efforts to control infectious diseases, 1851 to the present. JAMA, 292, 1474–1479. [DOI] [PubMed] [Google Scholar]
  • 41.Shattuck L. (1850) Louisiana State University, Baton Rouge The Medical and Public Health Law Site; [cited 2007 May 25]. Available from: http://biotech.law.lsu.edu/cphl/history/books/sr/.
  • 42.Wilcox L.S. (2005) Health education from 1775 to 2005. Prev. Chronic. Dis., 2 Spec no, A01. Epub. 2005 Nov. 1. [PMC free article] [PubMed] [Google Scholar]
  • 43.Christmas W.A., and Dorman J.M. (1996) The Storey of college health hygiene. Thomas A. Storey, MD (1875–1943) and the promotion of hygiene. J. Am. Coll. Health, 45, 27–34. [DOI] [PubMed] [Google Scholar]
  • 44.Strasser S. (1996) Next to Godliness. [Review of: Hoy, S. Chasing dirt: the American pursuit of cleanliness. Oxford University Press, 1995; Williams, M. T. Washing “the great unwashed”: public baths in urban America, 1840–1920. Ohio State University Press, 1991]. Rev. Am. Hist., 24, 461–5. [PubMed] [Google Scholar]
  • 45.Pollard A.J. (2007) Childhood immunisation: what is the future? Arch. Dis. Child., 92, 426–433. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 46.Tengs T.O., Adams M.E., Pliskin J.S., Safran D.G., Siegel J.E., Weinstein M.C., and Graham J.D. (1995) Five-hundred life-saving interventions and their cost-effectiveness. Risk Anal., 15, 369–390. [DOI] [PubMed] [Google Scholar]
  • 47.Vallin J., and Mesle F. (2004) Convergences and divergences in mortality. A new approach to health transition. Demographic Research, accessed April 7th, 2007 at http://www.demographic-research.org2, 12–44.
  • 48.Olshansky S.J., and Ault A.B. (1986) The fourth stage of the epidemiologic transition: the age of delayed degenerative diseases. Milbank Q, 64, 355–391. [PubMed] [Google Scholar]
  • 49.Frenk J., Bobadilla J.L., Stern C., Frejka T., and Lozano R. (1991) Elements for a theory of the health transition. Health Transit. Rev., 1, 21–38. [PubMed] [Google Scholar]
  • 50.Caselli G. (1995) The key phases of the European health transition. Pol. Popul. Rev., 73–102. [PubMed] [Google Scholar]
  • 51.Gurven M., Kaplan H., and Supa A.Z. (2007) Mortality experience of Tsimane Amerindians of Bolivia: Regional variation and temporal trends. Am. J. Hum. Biol., 19, 376–398. [DOI] [PubMed] [Google Scholar]
  • 52.Hill K., Vapattanawong P., Prasartkul P., Porapakkham Y., Lim S.S., and Lopez A.D. (2006) Epidemiologic transition interrupted: a reassessment of mortality trends in Thailand, 1980–2000. Int. J. Epidemiol., 36, 374–384. Epub. 2006 Dec. 20. [DOI] [PubMed] [Google Scholar]
  • 53.Castillo-Salgado C., Mujica O., and Loyola E. (1999) A subregional assessment of demographic and health trends in the Americas: 1980–1998. Stat. Bull. Metrop. Insur Co., 80, 2–12. [PubMed] [Google Scholar]
  • 54.Serow W.J., Cowart M.E., and Camezon J. (1998) Epidemiologic transition theory and aging: Hispanic populations of North America and the Caribbean. J. Health Hum. Serv. Adm., 20, 333–347. [PubMed] [Google Scholar]
  • 55.Hill K., Barker B., and Vos T. (2007) Excess Indigenous mortality: are Indigenous Australians more severely disadvantaged than other Indigenous populations? Int. J. Epidemiol., ????? [DOI] [PubMed] [Google Scholar]
  • 56.Hetzel D.M. (2001) Death, disease and diversity in Australia, 1951 to 2000. Med. J. Aust., 174, 21–24. [DOI] [PubMed] [Google Scholar]
  • 57.Rychtarikova J., Vallin J., and Mesle F. (1989) Comparative study of mortality trends in France and the Czech Republic since 1950. Popul., 44, 291–321. [PubMed] [Google Scholar]
  • 58.Shkolnikov V.M., Andreev E.M., Anson J., and Mesle F. (2004) The peculiar pattern of mortality of Jews in Moscow, 1993–95. Popul. Stud. (Camb)., 58, 311–329. [DOI] [PubMed] [Google Scholar]
  • 59.Caselli G., Meslé F., and Vallin J. (2003) Epidemiologic transition theory exceptions. Max Planck Institute for Demographic Research, accessed May 2. 2007 from http://www.demogr.mpg.de/Papers/workshops/020619_paper40.pdf.
  • 60.Vallin J. (2007) Commentary: ‘Epidemiologic transition’ interrupted or sweep to the second stage of ‘health transition'? Int. J. Epidemiol., 36, 384–386. Epub. 2007 Apr. 30. [DOI] [PubMed] [Google Scholar]
  • 61.Coussy J., and Vallin J. (1996) Crisis and demographic transition in Africa. Chron. CEPED., 1–5. [PubMed] [Google Scholar]
  • 62.Timaeus I.M. (1998) Impact of the HIV epidemic on mortality in sub-Saharan Africa: evidence from national surveys and censuses. AIDS, 12 Suppl 1, S15–27. [PubMed] [Google Scholar]
  • 63.King G., and Zeng L. (2001) Improving Forecasts of State Failure. World Politics, 53, 623–658. [Google Scholar]
  • 64.Victora C.G., Wagstaff A., Schellenberg J.A., Gwatkin D., Claeson M., and Habicht J.P. (2003) Applying an equity lens to child health and mortality: more of the same is not enough. lancet, 362, 233–241. [DOI] [PubMed] [Google Scholar]
  • 65.Meslé F. (2004) Mortality in Central and Eastern Europe: long-term trends and recent upturns. Demographic Research, accessed April 7th, 2007 at http://www.demographic-research.org 2, 46–70.
  • 66.Okolski M. (1992) Anomalies in demographic transition in Poland. Geogr. Pol., 59, 41–53. [PubMed] [Google Scholar]
  • 67.Tkatchenko E., McKee M., and Tsouros A.D. (2000) Public health in Russia: the view from the inside. Health Policy Plan, 15, 164–169. [DOI] [PubMed] [Google Scholar]
  • 68.Tulchinsky T.H., and Varavikova E.A. (1996) Addressing the epidemiologic transition in the former Soviet Union: strategies for health system and public health reform in Russia. Am. J. Public Health, 86, 313–320. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 69.Shkolnikov V., Meslé F., and Vallin J. (1996) Health crisis in Russia. I. Recent trends in life expectancy and causes of death from 1970 to 1993. Popul., 8, 123–154. [PubMed] [Google Scholar]
  • 70.Boutayeb A. (2006) The double burden of communicable and non-communicable diseases in developing countries. Trans. R. Soc. Trop. Med. Hyg., 100, 191–199. [DOI] [PubMed] [Google Scholar]
  • 71.Murray C.J.L., and Lopez A.D. (1996) The global burden of disease: a comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020. Published by the Harvard School of Public Health on behalf of the World Health Organization and the World Bank; Distributed by Harvard University Press, Cambridge, MA (USA).
  • 72.Boerma J.T., and Stansfield S.K. (2007) Health statistics now: are we making the right investments? lancet, 369, 779–786. [DOI] [PubMed] [Google Scholar]
  • 73.Mathers C.D., Fat D.M., Inoue M., Rao C., and Lopez A.D. (2005) Counting the dead and what they died from: an assessment of the global status of cause of death data. Bull. World Health Organ., 83, 171–177. [PMC free article] [PubMed] [Google Scholar]
  • 74.(2005) Stumbling around in the dark. lancet, 365, 1983. [PubMed] [Google Scholar]
  • 75.AbouZahr C., and Vaughan J.P. (2000) Assessing the burden of sexual and reproductive ill-health: questions regarding the use of disability-adjusted life years. Bull. World Health Organ., 78, 655–666. [PMC free article] [PubMed] [Google Scholar]
  • 76.Anand S., and Hanson K. (1997) Disability-adjusted life years: a critical review. J. Health Econ., 16, 685–702. [DOI] [PubMed] [Google Scholar]
  • 77.Mont D. (2007) Measuring health and disability. Lancet, 369, 1658–1663. [DOI] [PubMed] [Google Scholar]
  • 78.Bloom D.E., Canning D., and Weston M. (2005) The Value of Vaccination. World Economics, 6, 15–30. [Google Scholar]
  • 79.Niehaus M.D., Moore S.R., Patrick P.D., Derr L.L., Lorntz B., Lima A.A., and Guerrant R.L. (2002) Early childhood diarrhea is associated with diminished cognitive function 4 to 7 years later in children in a northeast Brazilian shantytown. Am. J. Trop. Med. Hyg., 66, 590–593. [DOI] [PubMed] [Google Scholar]
  • 80.Dillingham R., and Guerrant R.L. (2004) Childhood stunting: measuring and stemming the staggering costs of inadequate water and sanitation. Lancet, 363, 94–95. [DOI] [PubMed] [Google Scholar]
  • 81.Guerrant D.I., Moore S.R., Lima A.A., Patrick P.D., Schorling J.B., and Guerrant R.L. (1999) Association of early childhood diarrhea and cryptosporidiosis with impaired physical fitness and cognitive function four-seven years later in a poor urban community in northeast Brazil. Am. J. Trop. Med. Hyg., 61, 707–713. [DOI] [PubMed] [Google Scholar]
  • 82.Edmunds W., Dejene A., Mekonnen Y., Haile M., Alemnu W., and Nokes D. (2000) The cost of integrating hepatitis B virus vaccine into national immunization programmes: a case study from Addis Ababa. Health Policy Plan, 15, 408–16. [DOI] [PubMed] [Google Scholar]
  • 83.Miguel E., and Kremer M. (2004) Worms: identifying impacts on education and health in the presence of treatment externalities. Econometrica, 72, 159–217. [Google Scholar]
  • 84.Mendez M.A., and Adair L.S. (1999) Severity and timing of stunting in the first two years of life affect performance on cognitive tests in late childhood. J. Nutr., 129, 1555–1562. [DOI] [PubMed] [Google Scholar]
  • 85.Pritchett L., and Summers L.H. (1993) Wealthier is healthier (Office of the Vice President Development Economics World Bank, Washington, D.C.). [Google Scholar]
  • 86.Bloom D.E., and Canning D. (2000) Policy forum: public health. The health and wealth of nations. Science, 287, 1207, 1209. [DOI] [PubMed] [Google Scholar]
  • 87.Bloom D.E., Canning D., and Sevilla J. (2004) The effect of health on economic growth: a production function approach. World Development, 32, 1–13. [Google Scholar]
  • 88.World Health Organization. Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003.: access on June 9, 2007 at http://www.who.int/csr/sars/country/table2004_04_21/en/index.html
  • 89.Smith R.D. (2006) Responding to global infectious disease outbreaks: lessons from SARS on the role of risk perception, communication and management. Soc. Sci. Med., 63, 3113–3123. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 90.Barreto M.L. (2003) Science, policy, politics, a complex and unequal world and the emerging of a new infectious disease. J. Epidemiol. Community Health, 57, 644–645. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 91.Blendon R.J., Benson J.M., DesRoches C.M., Raleigh E., and Taylor-Clark K. (2004) The public's response to severe acute respiratory syndrome in Toronto and the United States. Clin. Infect. Dis., 38, 925–931. [DOI] [PubMed] [Google Scholar]
  • 92.Calvin L. In: International Trade and Food Safety: Economic Theory and Case Studies, Busby J.C. (ed.) (2003) United States Department of Agriculture, Economic Research Service; (AER-828). [Google Scholar]
  • 93.Belton D.J. (2004) The macro-economic impact of a foot-and-mouth disease incursion in New Zealand. Dev Biol. (Basel), 119, 457–461. [PubMed] [Google Scholar]
  • 94.Garner M.G., Fisher B.S., and Murray J.G. (2002) Economic aspects of foot and mouth disease: perspectives of a free country, Australia. Rev. Sci. Tech., 21, 625–635. [DOI] [PubMed] [Google Scholar]
  • 95.Krystynak R.H., and Charlebois P.A. (1987) The Potential Economic Impact of an Outbreak of Foot-and-Mouth Disease in Canada. Can. Vet. J., 28, 523–527. [PMC free article] [PubMed] [Google Scholar]
  • 96.Paarlberg P.L., Lee J.G., and Seitzinger A.H. (2002) Potential revenue impact of an outbreak of foot-and-mouth disease in the United States. J. Am. Vet. Med. Assoc., 220, 988–992. [DOI] [PubMed] [Google Scholar]
  • 97.Perry B.D., Gleeson L.J., Khounsey S., Bounma P., and Blacksell S.D. (2002) The dynamics and impact of foot and mouth disease in smallholder farming systems in South-East Asia: a case study in Laos. Rev. Sci. Tech., 21, 663–673. [DOI] [PubMed] [Google Scholar]
  • 98.Perry B.D., Kalpravidh W., Coleman P.G., Horst H.S., Dermott J.J., Randolph T.F., and Gleeson L.J. (1999) The economic impact of foot and mouth disease and its control in South-East Asia: a preliminary assessment with special reference to Thailand. Rev. Sci. Tech., 18, 478–97. [DOI] [PubMed] [Google Scholar]
  • 99.Perry B.D., and Rich K.M. (2007) Poverty impacts of foot-and-mouth disease and the poverty reduction implications of its control. Vet. Rec., 160, 238–241. [DOI] [PubMed] [Google Scholar]
  • 100.Randolph T.F., Perry B.D., Benigno C.C., Santos I.J., Agbayani A.L., Coleman P., Webb R., and Gleeson L.J. (2002) The economic impact of foot and mouth disease control and eradication in the Philippines. Rev. Sci. Tech., 21, 645–661. [DOI] [PubMed] [Google Scholar]
  • 101.Hall C. (2004) Impact of avian influenza on U.S. poultry trade relations-2002: H5 or H7 low pathogenic avian influenza. Ann. N.Y. Acad. Sci., 1026, 47–53. [DOI] [PubMed] [Google Scholar]
  • 102.Spread of Avian Flu Could Affect Next Year's Economic Outlook. In: The World Bank. East Asia Update–Countering Global Shocks, accessed June 9, 2007 from http://www.worldbank.org/eapupdate.
  • 103.Bramhmbhatt M. (2006) Economic Impacts of Avian Influenza Propagation, In: First International Conference on Avian Influenza in Humans, June 29, 2006; Paris, France.
  • 104.(2006) Economic and social impact of epidemic and pandemic influenza. Vaccine, 24, 6776–6778. [DOI] [PubMed] [Google Scholar]
  • 105.International Monetary Fund. Avian Flu Working Group. The global economic and financial impact of an avian flu pandemic and the role of the IMF (International Monetary Fund, Washington, D.C., 2006). [Google Scholar]
  • 106.Brundtland G.H. Health brings wealth, in BBC News Online: Business, Friday, 23 March, 2001: BBC, London. [Google Scholar]
  • 107.Folch E., Hernandez I., Barragan M., and Franco-Paredes C. (2003) Infectious diseases, non-zero-sum thinking, and the developing world. Am. J. Med. Sci., 326, 66–72. [DOI] [PubMed] [Google Scholar]
  • 108.United Nations Millennium Declaration Resolution 55/2 adopted by the General Assembly in Millennium Summit. 2000. accessed from http://www.u-n.org/millennium/ on June 9, 2007.
  • 109.Shiftman J. (2006) Donor funding priorities for communicable disease control in the developing world. Health Policy Plan, 21, 411–420. [DOI] [PubMed] [Google Scholar]
  • 110.Wagstaff A. (2001) Economics, health and development: some ethical dilemmas facing the World Bank and the international community. J. Med. Ethics, 27, 262–267. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 111.(2007) Millennium development holes. Nature, 446, 347. [DOI] [PubMed] [Google Scholar]
  • 112.Bloom D.E. (2006) Education in a globalized world. World Economics, 1, 87–109. [Google Scholar]
  • 113.Hawkes C., and Ruel M. (2006) The links between agriculture and health: an intersectoral opportunity to improve the health and livelihoods of the poor. Bull. World Health Organ., 84, 984–990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 114.World Bank (1998) Assessing aid: what works, what doesn't, and why Assessing aid. World Bank policy research report. Washington, D.C.: Oxford University Press. xii, 148. [Google Scholar]
  • 115.Wagstaff A., Claeson M. and World Bank. (2004) The millennium development goals for health: rising to the challenges. Washington, DC: World Bank. xv, 186. [Google Scholar]
  • 116.Lewis M. (2006) Governance and Corruption in Public Health Care Systems. Working Paper Number 78. Center for Global Development; (www.cgdev.org). [Google Scholar]
  • 117.Gayle H.D., and Hill G.L. (2001) Global impact of human immunodeficiency virus and AIDS. Clin. Microbiol. Rev., 14, 327–335. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 118.UNAIDS (2006) Report on the Global AIDS Epidemic. Accessed May 20, 2007 at http://www.unaids.org/en/HIV_data/2006GlobalReport/default.asp
  • 119.Steinbrook R. (2007). HIV in India–a complex epidemic. N. Engl. J. Med., 356, 1089–1093. [DOI] [PubMed] [Google Scholar]
  • 120.Bertozzi S., Padian N.S., Wegbreit J., DeMaria L.M., Feldman B., Gayle H., Gold J., Grant R., and Isbell M.T. (2006) HIV/AIDS prevention and treatment in Disease Control Priorities in Developing Countries. Jamison D. T. (ed.), Oxford University Press, New York, NY. [Google Scholar]
  • 121.Nicoll A., and Gill O.N. (1999) The global impact of HIV infection and disease. Commun. Dis. Public Health, 2, 85–95. [PubMed] [Google Scholar]
  • 122.UNAIDS (2006) Report on the Global AIDS Epidemic. Geneva, Switzerland, 1999. [Google Scholar]
  • 123.Yeni P.G., Hammer S.M., Hirsch M.S., Saag M.S., Schechter M., Carpenter C.C., Fischl M.A., Gatell J.M., Gazzard B.G., Jacobsen D.M., Katzenstein D.A., Montaner J.S., Richman D.D., Schooley R.T., Thompson M.A., Vella S., and Volberding P.A. (2004). Treatment for adult HIV infection: 2004 recommendations of the International AIDS Society-USA Panel. JAMA, 292, 251–265. [DOI] [PubMed] [Google Scholar]
  • 124.Zenilman J.M. (2005) Behavioral interventions–rationale, measurement, and effectiveness. Infect. Dis. Clin. North. Am., 19, 541–562. [DOI] [PubMed] [Google Scholar]
  • 125.Hearst N., and Chen S. (2004) Condom promotion for AIDS prevention in the developing world: is it working? Stud. Fam. Plann., 35, 39–47. [DOI] [PubMed] [Google Scholar]
  • 126.World Health Organization (2004) Tuberculosis Epidemiology accessed July 7, 2006 at http://www.who.int/tb/hiv/faw/en/index.html.
  • 127.Corbett E.L., Watt C.J., Walker N., Maher D., Williams B.G., Raviglione M.C., and Dye C. (2003) The growing burden of tuberculosis: global trends and interactions with the HIV epidemic. Arch. Intern. Med., 163, 1009–1021. [DOI] [PubMed] [Google Scholar]
  • 128.Khatri G.R., and Frieden T.R. (2002) Controlling tuberculosis in India. N. Engl. J. Med., 347, 1420–1425. [DOI] [PubMed] [Google Scholar]
  • 129.Okeke I.N., Laxminarayan R., Bhutta Z.A., Duse A.G., Jenkins P., O'Brien T.F., Pablos-Mendez A., and Klugman K.P. (2005) Antimicrobial resistance in developing countries. Part I: recent trends and current status. Lancet Infect. Dis., 5, 481–493. [DOI] [PubMed] [Google Scholar]
  • 130.Frieden T.R., Sterling T.R., Munsiff S.S., Watt C.J., and Dye C. (2003) Tuberculosis. Lancet, 362, 887–899. [DOI] [PubMed] [Google Scholar]
  • 131.Rieder H.L. BCG vaccines in Clinical Tuberculosis, Davies P.D.O. (ed.), Arnold Publishers, London, 337–353. [Google Scholar]
  • 132.Maitland K., Bejon P., and Newton C.R. (2003) Malaria. Curr. Opin. Infect. Dis., 16, 389–95. [DOI] [PubMed] [Google Scholar]
  • 133.Kosek M., Bern C., and Guerrant R.L. (2003) The global burden of diarrhoeal disease, as estimated from studies published between 1992 and 2000. Bull. World Health Organ., 81, 197–204. [PMC free article] [PubMed] [Google Scholar]
  • 134.Cheng A.C., McDonald J.R., and Thielman N.M. (2005) Infectious diarrhea in developed and developing countries. J. Clin. Gastroenterol., 39, 757–773. [DOI] [PubMed] [Google Scholar]
  • 135.Giaquinto C., Van Damme P., Huet F., Gothefors L., Maxwell M., Todd P., and da Dalt L. (2007) Clinical consequences of rotavirus acute gastroenteritis in Europe, 2004–2005: the REVEAL study. J. Infect. Dis., 195 Suppl 1, S26–S35. [DOI] [PubMed] [Google Scholar]
  • 136.Dennehy P.H. (2007) Rotavirus vaccines-an update. Vaccine, 25, 3137–3141. Epub. 2007 Feb. 9. [DOI] [PubMed] [Google Scholar]
  • 137.GAVI Alliance (2005) GAVI alliance general information. accessed on May 28, 2007 at http://www.vaccinealliance.org.
  • 138.Brenzel L., Wolfson L.J., Fox-Rushby J., Miller M., and Halsey N.A. (2006) Vaccine Preventable Diseases. In: In Disease Control Priorities in Developing Countries, Jamison D. T. (ed.), Oxford University Press, New York, NY, 2006. [Google Scholar]
  • 139.Roberts L. (2004) Polio endgame. The exit strategy. Science, 303, 1969–1971. [DOI] [PubMed] [Google Scholar]
  • 140.WHO (2001) Global prevalence and incidence of selected curable sexually transmitted infections: Overview and estimates. Accessed on May 28, 2006 at http://www.who.int/hiv/pub/sti/pub7/en/. [PubMed]
  • 141.Wasserheit J.N., and Aral S.O. (1996) The dynamic topology of sexually transmitted disease epidemics: implications for prevention strategies. J. Infect. Dis., 17A Suppl 2, S201–S213. [DOI] [PubMed] [Google Scholar]
  • 142.Laga M., Nzila N., and Goeman J. (1991) The interrelationship of sexually transmitted diseases and HIV infection: implications for the control of both epidemics in Africa. Aids, 5, S55–S63. [PubMed] [Google Scholar]
  • 143.Stephenson L.S., Latham M.C., and Ottesen E.A. (2000) Malnutrition and parasitic helminth infections. Parasitology, 121, S23–S38. [DOI] [PubMed] [Google Scholar]
  • 144.Engels D., and Savioli L. (2006) Reconsidering the underestimated burden caused by neglected tropical diseases. Trends Parasitol., 22, 363–366. Epub. 2006 Jun 23. [DOI] [PubMed] [Google Scholar]
  • 145.Gubler D.J. (2006) Dengue/dengue haemorrhagic fever: history and current status. Novartis Found Symp., 211, 3–16. [DOI] [PubMed] [Google Scholar]
  • 146.Wilder-Smith A., and Schwartz E. (2005) Dengue in travelers. N. Engl. J. Med., 353, 924–932. [DOI] [PubMed] [Google Scholar]
  • 147.Isturiz R.E., Gubler D.J., and Brea del Castillo J. (2000) Dengue and dengue hemorrhagic fever in Latin America and the Caribbean. Lnfect. Dis. Clin. North Am., 14, 121–140, ix. [DOI] [PubMed] [Google Scholar]
  • 148.Melino S., and Paci M. (2007) Progress for dengue virus diseases. Febs. J., 274, 2986–3002. Epub. 2007 May 17. [DOI] [PubMed] [Google Scholar]
  • 149.Herwaldt B.L. (1999) Leishmaniasis. Lancet, 354, 1191–1199. [DOI] [PubMed] [Google Scholar]
  • 150.Murray H.W., Berman J.D., Davies C.R., and Saravia N.G. (2005). Advances in leishmaniasis. Lancet, 366, 1561–1577. [DOI] [PubMed] [Google Scholar]
  • 151.Pepin J., and Meda H.A. (2001) The epidemiology and control of human African trypanosomiasis. Adv. Parasitol., 49, 71–132. [DOI] [PubMed] [Google Scholar]
  • 152.Smith D.H., Pepin J., and Stich A.H. (1998) Human African trypanosomiasis: an emerging public health crisis. Br. Med. Bull., 54, 341–355. [DOI] [PubMed] [Google Scholar]
  • 153.Murray C.J., Lopez A.D., Chin B., Feehan D., and Hill K.H. (2006) Estimation of potential global pandemic influenza mortality on the basis of vital registry data from the 1918–20 pandemic: a quantitative analysis. Lancet, 368, 2211–2218. [DOI] [PubMed] [Google Scholar]
  • 154.Chretien J.P., Blazes D.L., Gaydos J.C., Bedno S.A., Coldren R.L., Culpepper R.C., Fyrauff D.J., Earhart K.C., Mansour M.M., Glass J.S., Lewis M.D., Smoak B.L., and Malone J.L. (2006) Experience of a global laboratory network in responding to infectious disease epidemics. Lancet Infect. Dis., 6, 538–540. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 155.Chretien J.P., Gaydos J.C., Malone J.L., and Blazes D.L. (2006) Global network could avert pandemics. Nature, 440, 25–26. [DOI] [PubMed] [Google Scholar]
  • 156.Cash R.A., and Narasimhan V. (2000) Impediments to global surveillance of infectious diseases: consequences of open reporting in a global economy. Bull. World Health Organ., 78, 1358–1367. [PMC free article] [PubMed] [Google Scholar]
  • 157.Bresee J., Fang Z.Y., Wang B., Nelson E.A., Tarn J., Soenarto Y., Wilopo S.A., Kilgore P., Kim J.S., Kang J.O., Lan W.S., Gaik C.L., Moe K., Chen K.T., Jiraphongsa C., Ponguswanna Y., Nguyen V.M., Phan V.T., Le T.L., Hummelman E., Gentsch J.R., and Glass R. (2004) First report from the Asian Rotavirus Surveillance Network. Emerg. Infect. Dis., 10, 988–95. [DOI] [PMC free article] [PubMed] [Google Scholar]

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