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. 2019 Feb 27;85(4):347–358. doi: 10.3184/003685002783238762

Comparative Biology of γδ T Cells

Zheng W Chen 1,✉
PMCID: PMC10367533  PMID: 12661423

Abstract

Accumulative evidence suggests that resident γδ T cells in epithelia are biologically distinct from systemic γδ T cells in the circulation. Murine resident γδ T cells have innate immune characteristics and play an important role in tissue homeostasis after damages. In contrast, a unique subset of circulating γδ T cells in primates, like αβ T cells, can mount adaptive immune responses in infections. This article compares biological features between resident and circulating γδ T cells.

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