Table 4. A summary of recent studies describing the treatment regimen used to treat port-site infections.
NTM: Non-tuberculous mycobacteria; PO: Per os (oral); IV: Intravenous
Serial | Study, NTM species | Treatment | Clinical Relapse |
1. | Ghosh et al. [6], M. abscessus and M. fortuitum | Medical treatment based on drug sensitivity | No |
2. | Ramesh et al. [14], M. tuberculosis | Surgical debridement + Standard first-line antitubercular regimen; rifampicin, isoniazid, pyrazinamide and ethambutol for 2 mo followed by rifampicin and isoniazid for 9 months | No |
3. | Shah et al. [18], M. fortuitum, M. chelonae | Medical treatment only; clarithromycin (PO 6-9 months); ciprofloxacin (PO 6-9 months) | No |
4. | Bhattacharjee et al. [19], 2015; species not specified | Medical treatment only; clarithromycin (PO 1-3 months); ciprofloxacin (PO 1-3 months) | Persistent skin nodules in 5 cases. Treated with amikacin (local injection 5 days) |
5. | Chaudhuri et al. [5], 2010 M. fortuitum-chelonae complex | Medical treatment only; clarithromycin (PO 1-3 months) and ciprofloxacin (PO 1-3 months) | Persistent skin nodules in 7 cases. Treated with amikacin (local injection 5 days) |
6. | Duarte et al. [20]; 2009, M. bolletii or M. massiliense | Surgical debridement + medical treatment; clarithromycin (PO 6 months); amikacin or imipenem or cefoxitin (IV 6 months) | No |
7. | Vijayaraghavan et al. [21]; 2006; M. chelonae | Medical treatment only; ciprofloxacin (PO 2-18 months) and amikacin (IV 2-18 months) | No |
8. | Krishnappa and Samarasam [22], 2017, M. chelonae and M. fortuitum | Surgical debridement and medical treatment; ciprofloxacin (PO 3 months) OR levofloxacin (PO 3 months) and clarithromycin (PO 3 months) and amikacin (IV 3 months) | Recurrence seen in three patients; medical retreatment with the same antibiotics |
9. | Lahiri et al. [17], 2009, M. fortuitum | Surgical debridement + medical treatment; amikacin or imipenem (IV 6 weeks) and ciprofloxacin or clarithromycin (PO 6 weeks) | No |
10. | Muthusami et al. [13], 2004, M. fortuitum | Surgical debridement + medical treatment; amikacin (IV 6 weeks-3 months) and ciprofloxacin (PO 6 weeks-3 months) | One patient relapsed after 3 months amikacin (IV; 3 months) |
11. | Samaranayake et al. [23], 2008, NTM | Surgical excision of the sinus tract Medical treatment with trimethoprim-sulfamethoxazole (PO 3 months), ciprofloxacin (PO 3 months), and/or amikacin (IV 3 months) | No |
12. | Wright et al. [25], 2014, M. fortuitum and M. abscessus | Medical treatment only amikacin, cefoxitin, and imipenem (IV 2-6 weeks); clarithromycin/doxycycline/ minocycline (PO 3-6 months); combination therapy with ciprofloxacin and cotrimoxazole used for M. fortuitum | All relapsed - required removal of the device (gastric band) |
13. | Current study | Surgical excision of the sinus tract; medical treatment with clarithromycin (PO 3 months); ciprofloxacin (PO 3 months) | No relapse |