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. 2023 Jul 3;26(8):107272. doi: 10.1016/j.isci.2023.107272

Figure 5.

Figure 5

Tumor-specificity and biodistribution of ICAM1-ADC in nude mice

(A) in vivo NIR fluorescent images of nude mice at 48h after the administration of IgG-Cy5.5 or I1-MMAE-Cy5.5.

(B) Representative ex vivo NIR fluorescent images of six major organs including brain, lung, heart, spleen, liver, and kidney.

(C) Quantified tumor accumulation of IgG-Cy5.5 or I1-MMAE-Cy5.5; Students’ T test was employed to compare difference; ∗p < 0.05.

(D) Quantified normal major organ accumulation of IgG-Cy5.5 or I1-MMAE-Cy5.5.