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. Author manuscript; available in PMC: 2023 Jul 28.
Published in final edited form as: Pharmacotherapy. 2023 Jan 27;43(7):675–690. doi: 10.1002/phar.2767

FIGURE 4.

FIGURE 4

Plasma selective serotonin reuptake inhibitor concentrations with missed doses and during hyperbolic discontinuation. The effect of missed doses (*) can be seen in an adolescent treated with 15 mg daily of escitalopram (A) and 150 mg daily of sertraline (B) who is a normal metabolizer for CYP2C19. However, these effects are amplified in the same adolescent treated with escitalopram 15 mg daily (C) or sertraline 150 mg daily (D), if she is an ultrarapid CYP2C19 metabolizer. Hyperbolic discontinuation of escitalopram (E) and sertraline (F and G) is shown with dosing shown in gray bars. Pharmacokinetic models were developed for a 14-year-old female weighing 52 kg with a height of 162 cm. Green curves represent escitalopram, and blue curves represent sertraline