Abstract
The results of a follow-up study of 100 men first examined in 1953 after exposure to cadmium oxide fume are presented and discussed.
In 1953 there were 19 cases of chronic cadmium poisoning amongst these men. Twenty-four new cases are now described. The first signs of chronic cadmium poisoning could be seen after a latent interval after exposure had ended. Respiratory function tests showed a greater deterioration in performance with increase in age in the exposed groups compared with the control group. The results in individual cases of clinical and radiological examination and of the respiratory function tests showed a deterioration in the condition of those men with emphysema in the original survey, and took place despite the fact that the majority of the men with chronic cadmium poisoning were not further exposed to cadmium after 1953. Eighteen of the 24 new cases had proteinuria only.
The evidence that chronic cadmium poisoning is associated with renal damage is discussed.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BERNSTEIN L., D'SILVA J. L., MENDEL D. The effect of the rate of breathing on the maximum breathing capacity determined with a new spirometer. Thorax. 1952 Sep;7(3):255–262. doi: 10.1136/thx.7.3.255. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CLARKSON T. W., KENCH J. E. Urinary excretion of amino acids by men absorbing heavy metals. Biochem J. 1956 Mar;62(3):361–372. doi: 10.1042/bj0620361. [DOI] [PMC free article] [PubMed] [Google Scholar]
- D'SILVA J. L., FREELAND D. E., KAZANTZIS G. The performance of patients with ankylosing spondylitis in the maximum ventilatory capacity test. Thorax. 1953 Dec;8(4):303–308. doi: 10.1136/thx.8.4.303. [DOI] [PMC free article] [PubMed] [Google Scholar]
- D'SILVA J. L., KAZANTZIS G. Measurement of the mechanical function of the lung in normal subjects. Thorax. 1954 Jun;9(2):128–135. doi: 10.1136/thx.9.2.128. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DALHAMN T., FRIBERG L. Morphological investigations on kidney damage in chronic cadmium poisoning; an experimental investigation on rabbits. Acta Pathol Microbiol Scand. 1957;40(6):475–479. [PubMed] [Google Scholar]
- GANDEVIA B., HUGH-JONES P. Terminology for measurements of ventilatory capacity; a report to the thoracic society. Thorax. 1957 Dec;12(4):290–293. doi: 10.1136/thx.12.4.290. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SMITH J. C., KENCH J. E. Observations on urinary cadmium and protein excretion in men exposed to cadmium oxide dust and fume. Br J Ind Med. 1957 Oct;14(4):240–245. doi: 10.1136/oem.14.4.240. [DOI] [PMC free article] [PubMed] [Google Scholar]