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. 2023 Jul 22;94:104731. doi: 10.1016/j.ebiom.2023.104731

Fig. 4.

Fig. 4

Beta diversity of the salivary microbiome over time. Panels: A. PCoA plots of unweighted and B. weighted UniFrac analyses of all timepoints for the 34 exposed subjects from before, during, and after viral positivity [colored by status relative to SARS-CoV2 infection] and their 31 matched unexposed subjects. C. Resilience of microbiome composition assessed by within-subject pairwise unweighted and D. weighted UniFrac distances between the first sample and later time points. Left panels: SARS-CoV-2-infected subjects (n = 34) before, during, and after viral positivity and their 31 matched unexposed subjects, with the study week shown relative to COVID infection with the week of the first positive test defined as week 0. Right panels: SARs-CoV-2-infected subjects (n = 47) who were virus-positive at the first study visit and their 41 matched unexposed subjects. No significant differences were found between exposed and unexposed subjects (p > 0.05) when controlling for age and week of sampling, using linear mixed effects modeling.