Figure 22.

A 3D graph illustrating the predicted and calculated anti-ischemic activity of steroid phosphate esters, specifically compounds 111, 112, 113, and 114. The graph depicts the relationship between the activity of these compounds and their effectiveness in reducing myocardial oxygen consumption during ischemic conditions. The predicted and calculated activity values, depicted on the axes of the graph, represent the potency or efficacy of the steroid phosphate esters in terms of their anti-ischemic properties. The confidence level of over 93% indicates a high degree of certainty in the accuracy of the predicted and calculated activity values. Anti-ischemic activity refers to the ability of a compound to mitigate the detrimental effects of reduced blood flow and inadequate oxygen supply to the heart muscle. By reducing myocardial oxygen consumption, these steroid phosphate esters hold promise in preventing or alleviating ischemic episodes and related cardiac complications. It is important to note that further research, including experimental validation and clinical trials, is necessary to fully understand the mechanisms of action and optimal applications of these steroid phosphate esters as anti-ischemic agents. Their potential therapeutic implications in the context of ischemic heart disease warrant exploration to develop effective treatments for this condition.