Table 1.

Putative protein functions, mainly derived from Vaccinia and Variola.

Gene	Putative Function	References
LSDV008	A putative soluble interferon gamma receptor.	[16]
LSDV009	A putative alpha aminitin-sensitive protein.	[16]
LSDV026	Thought to be unique to LSDV in Capripox, acts as potential rho signaling inhibitor which may explain the formation of nodules as the ‘rho GTPases.	[75]
LSDV045	Involved in replication and recombination.	[16]
LSDV046	Involved in membrane formation.	[16]
LSDV067	Is a putative host range protein, similar to VACCP-C7L, which is suggested to interact with SAMD9. SAMD9 is involved in cell death signaling and is an innate antiviral host factor.	[16,18,76]
LSDV061	Encodes a membrane precursor of immature virions and virus factories.	[16]
LSDV062	Involved in early transcription, otherwise unknown function.	[69,70]
LSDV098	Is a protein that also encodes for the early transcription factor 82 kDa subunit. This is part of the early transcription machinery.	[69,70]
LSDV128	Membrane regulation.	[16]
LSDV132	Unknown.	[16]
LSDV133	DNA ligase.	[16]
LSDV134	Is homologous to the Variola virus B22R-like protein.	[73,74]
LSDV076	Late transcription factor whose Vaccinia homologue H5R is thought to be required both for inclusion of virosomes into crescents and for maturation of immature virions into mature virions.	[71,72]
LSDV143-146	Are kelch-like and ankyrin repeat proteins.	[16]