Table 3.

Risk for metachronous CRC after detection and removal of polyp(s) at baseline colonoscopy analysed for co-occurrence of other polyp subtypes.

	Number of individuals	Number of CRC cases	Cases per 1000 person-years of follow-up	Unadjusted HR	p-value	Adjusted HRa	p-value
No polyps	70,468	115 (0.2%)	0.53	ref		ref
HP <10 mm, without SSLs, TSAs, or adenomas	5299	5 (0.1%)	0.32	0.629 (0.257–1.541)	0.311	NA	NA
Low-risk SSL without adenomas	1865	1 (0.1%)	0.20	0.414 (0.058–2.966)	0.380	NA	NA
Low-risk adenomas without low-risk SSL	38,906	48 (0.1%)	0.40	0.773 (0.552–1.083)	0.135	0.771 (0.549–1.082)	0.132
Low-risk adenomas with low-risk SSL	1708	3 (0.2%)	0.66	1.381 (0.439–4.346)	0.581	NA	NA
High-risk adenomas without high-risk serrated polyps	70,647	171 (0.2%)	0.68	1.218 (0.962–1.544)	0.102	1.222 (0.961–1.554)	0.101
High-risk serrated polyps without high-risk adenomas	7829	22 (0.3%)	0.89	1.679 (1.064–2.650)	0.026	1.702 (1.078–2.686)	0.022
High-risk serrated polyps with high-risk adenomas	4204	16 (0.4%)	1.08	1.917 (1.136–3.236)	0.015	2.003 (1.185–3.387)	0.010

HP: Hyperplastic polyp, SSL: Sessile serrated lesion, TSA: Traditional serrated adenoma.

^aAdjusted for age at baseline colonoscopy and sex.