Fig. 6.

Crowd-sourced assessment of the predictive potential of the SMaRT genes. a) Overview of our workflow and approach for crowd-sourced validation. Publicly available transcriptomic datasets reporting the outcome of intervention studies (genetic or pharmacologic manipulations) on macrophages/monocytes targeting any of the 185 genes in C#13 and C#14 were analysed using the BoNE platform for macrophage states. b) Predicted impact of positive (+, either overexpression [OvExp] or agonist stimulations) or negative (−; genetic −/− models, shRNA, or chemical inhibitors) interventions and observed macrophage polarization states are shown. Performance is measured by computing ROC AUC for a logistic regression model. See Supplementary Table S3.