FIGURE 3.

“Complete” Remodeling of the ECM in Lung Squamous Cell Cancer. (A) Supervised clustering analysis using partial least squares‐discriminant analysis (PLS‐DA) performed on protein groups quantified in the “Matched Normal” (brown) and “Tumor” (pink) samples. (B) Volcano plot of the 1802 quantified protein groups showing 202 down‐regulated and 327 up‐regulated protein groups for “Tumor” versus “Matched Normal” comparison. (C) 66 significantly altered protein groups are reported in the human MatrisomeDB [50] and are listed in Figure S4. Specific proteins from these significantly altered protein groups are listed in (D). (E‐F) Dot plots showing the ConsensusPathDB [47, 48] Gene Ontology (GO) biological processes enriched for protein groups significantly down‐regulated (E) and up‐regulated (F) in “Tumor” vs. “Matched Normal”