Abstract
Of 100 workers exposed to lead in varying degrees, 34 had a urinary delta amino-laevulinic acid (ALA) concentration of above 0·6 mg./100 ml. and a further 35 had an ALA concentration of between 0·3 mg. and 0·6 mg./100 ml. In only 20 of the workers was the urinary porphobilinogen concentration above 0·1 mg./100 ml., two of these being above 0·2 mg./100 ml.
No significant correlation was found between the urinary concentration of ALA and coproporphyrin, nor was there correlation between the ALA and urinary lead levels, in fact the highest level of ALA was associated with a urinary lead of less than 200 μg./litre. A raised urinary lead was always associated with a raised ALA.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- HOLTI G., RIMINGTON C., TATE B. C., THOMAS G. An investigation of porphyria cutanea tarda. Q J Med. 1958 Jan;27(105):1–18. [PubMed] [Google Scholar]
- KING E., THOMPSON A. R. The measurement of lead absorption in industry. Ann Occup Hyg. 1961 Jun;3:247–263. [PubMed] [Google Scholar]
- MAUZERALL D., GRANICK S. The occurrence and determination of delta-amino-levulinic acid and porphobilinogen in urine. J Biol Chem. 1956 Mar;219(1):435–446. [PubMed] [Google Scholar]
- RIMINGTON C., SVEINSSON S. L. The spectrophotometric determination of uroporphyrin. Scand J Clin Lab Invest. 1950;2(3):209–216. doi: 10.3109/00365515009049872. [DOI] [PubMed] [Google Scholar]
- TISHKOFF G. H., GRANVILLE N. B., ROSEN R., DAMESHEK W. Excretion of delta-aminolevulinic acid in lead intoxication. Acta Haematol. 1958 Jun;19(6):321–326. doi: 10.1159/000205451. [DOI] [PubMed] [Google Scholar]
- WATSON C. J., HAWKINSON V., BOSSENMAIER I. Some studies of the nature and clinical significance of porphobilinogen. Trans Assoc Am Physicians. 1953;66:144–155. [PubMed] [Google Scholar]
- WITH T. K. Porphyrin concentration from ultraviolet extinction; a note on the calculation. Scand J Clin Lab Invest. 1955;7(2):193–194. doi: 10.3109/00365515509134507. [DOI] [PubMed] [Google Scholar]
- ZONDAG H. A., VAN KAMPEN E. J. Spectral absorption of coproporphyrin in relation to the estimation in urine. Clin Chim Acta. 1956 Mar;1(2):127–134. doi: 10.1016/0009-8981(56)90028-6. [DOI] [PubMed] [Google Scholar]