aInstitute of Human Genetics, University of Marburg, Marburg, Germany
bInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany
cInstitute for Genomic Statistics and Bioinformatics, Medical Faculty, University of Bonn, Bonn, Germany
dDepartment of Upper GI Diseases, Karolinska University Hospital and Unit of Gastroenterology and Rheumatology, Karolinska Institutet, Stockholm, Sweden
eDepartment of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital Leipzig, Leipzig, Germany
fInstitute for Pathology, Friedrich-Alexander-University Erlangen-Nuernberg, Klinikum Bayreuth, Bayreuth, Germany
gDepartment of Digestive and Oncological Surgery, Claude Huriez Hospital, CHU Lille, Lille, France
hDepartment of General, Visceral, Cancer and Transplant Surgery, University of Cologne, Cologne, Germany
iDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany
jCentre for Surgical Oncology, Medias Klinikum Burghausen, Burghausen, Germany
kMolecular Oncology and Viral Pathology Group, IPO Porto Research Center (CI-IPOP), Portuguese Institute of Oncology of Porto (IPO Porto), 4200-072 Porto, Portugal
lPorto Comprehensive Cancer Center & RISE @ CI-IPO, University of Porto, 4200-450, Porto, Portugal
mInstitute of Medical Biometrics, Informatics and Epidemiology (IMBIE), Medical Faculty, University of Bonn, Bonn, Germany
nInstitute of Pathology, University Hospital Cologne, Medical Faculty, University of Cologne, Germany
oDepartment of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands
pPathology and Data Analytics, Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom
qDepartment of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland
rDepartment of Mathematics and Computer Science, University of Marburg, Marburg, Germany
sUniversity Cancer Center Leipzig, Leipzig University Medical Center, Leipzig, Germany
tDepartment of Gastroenterology, Hospital Costa del Sol, Marbella, Spain
uDepartment of Gastroenterology, Hospital Parc Tauli, Sabadell, Spain
vDepartment of Gastroenterology, Complejo Hospitalario, León, Spain
wDepartment of Gastroenterology, Hospital Clínico Universitario, Salamanca, Spain
xDepartment of Gastroenterology, Hospital Obispo Polanco, Teruel, Spain
yCIBER de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain
zDepartment of Gastroenterology, Hospital Donostia/Instituto Biodonostia, Universidad del País Vasco (UPV/EHU), San Sebastián, Spain
aaInstituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain
abDepartment of Gastroenterology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain
acInstituto Aragonés de Ciencias de la Salud (IACS), Zaragoza, Spain
adDepartment of Gastroenterology, Hospital Clinic of Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
aeKrankenhaus Nordwest, University Cancer Center, Frankfurt, Germany
afInstitut für Klinische Krebsforschung IKF GmbH am Krankenhaus Nordwest, Frankfurt, Germany
agDepartment of Upper GI Diseases, Karolinska University Hospital and Division of Surgery, Karolinska Institutet, Stockholm, Sweden
ahDepartment of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
aiGastroenterology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
ajDepartment of Woman and Child Health and Public Health - Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy
akSection of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Roma, Italy
alDipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Roma, Italy
amDipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy
anDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
aoDepartment of Surgery, RoMed Klinikum Rosenheim, Rosenheim, Germany
apInstitute of Microbiology, Infectious Diseases and Immunology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
aqDepartment of Anaesthesiology and operative Intensive care Medicine, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
arCharité Comprehensive Cancer Center, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
asDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
atDepartment of Genetics and Pathology, Pomeranian Medical University in Szczecin, Poland
auIndependent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University in Szczecin, Poland
avDepartment of Gastroenterology, Pomeranian Medical University in Szczecin, Poland
awUnit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Catalan Institute of Oncology (ICO), Hospital Duran I Reynals, Barcelona, Spain
axColorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
ayDepartment of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
azConsortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública e CIBERESP), Spain
baThe Research Group in Gene - Environment and Health Interactions (GIIGAS)/Institute of Biomedicine (IBIOMED), Universidad de Leon, Leon, Spain
bbDepartment of Biomedical Sciences, Faculty of Health Sciences, Area of Preventive Medicine and Public Health, Universidad de Leon, Leon, Spain
bcISGlobal, Barcelona, Spain
bdUniversitat Pompeu Fabra (UPF), Campus Del Mar, Barcelona, Spain
beIMIM (Hospital Del Mar Medical Research Institute), Barcelona, Spain
bfCancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
bgDepartment of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poland
bhUnidade de Xenética, Instituto de Ciencias Forenses (INCIFOR), Facultade de Medicina, Universidade de Santiago de Compostela, Santiago de Compostela, Spain
biGenPoB Research Group, Instituto de Investigación Sanitaria (IDIS), Hospital Clínico Universitario de Santiago (SERGAS), Santiago de Compostela, Spain
bjCentro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBER-ES), Madrid, Spain
bkCeRePP, Paris, France
blGRC n°5 Predictive Onco-Urology, Tenon Hospital, Sorbonne University, Paris, France
bmUniversity Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France
bnNeuroalgology Unit Fondazione IRCCS, Instituto Neurologico 'Carlo Besta' Milan, Milan, Italy
boEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia
bpMedical Oncology Unit, ASST of Cremona, Cremona, Italy
bqMedical Oncology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
brDepartment of Medical Oncology, Institut Jules Bordet - Université Libre de Bruxelles (ULB), Brussels, Belgium
bsUnit of Immunopathologia e Biomarcatori Oncologici/Bio-proteomics facility, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
btUnit of Immunopathologia e Biomarcatori Oncologici, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
buInstitute of Clinical and Preventive Medicine, University of Latvia, Riga East University Hospital, Riga, Latvia
bvGastroenterology Department and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania
bwDepartment of Medicine I, University Medical Center of Johannes Gutenberg University Mainz, Mainz, Germany
bxDepartment of General, Visceral and Transplant Surgery, University Medical Center, University of Mainz, Mainz, Germany
byDepartment of General and Visceral Surgery, Klinikum Frankfurt (Oder), Germany
bzDivision of Surgical Oncology and Thoracic Surgery, Department of Surgery, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
caDepartment of General Surgery, University Hospital Brandenburg, Brandenburg Medical School Theodor Fontane, Brandenburg, Germany
cbDepartment of General, Visceral, Thoracic and Vascular Surgery, University Hospital Bonn, Bonn, Germany
ccDepartment of General and Visceral Surgery, Klinikum Magdeburg GmbH, Magdeburg, Germany
cdInstitute of Quality Assurance in Operative Medicine, Otto-von-Guericke University Hospital, Magdeburg, Germany
ceDepartment of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany
cfPediatrics Department, Translational Pediatrics and Infectious Diseases Section, Hospital Clínico Universitario de Santiago (SERGAS), Santiago de Compostela, Spain
cgGenetics, Vaccines, Infectious Diseases and Pediatrics research group GENVIP, Instituto de Investigación Sanitaria de Santiago (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain
chInstitute of Biomedical Technologies, National Research Council of Italy, Milan, Italy
ciBio4Dreams-Business, Nursery for Life Sciences, Milan, Italy
cjDepartment of Clinical Sciences, Umeå University, Umeå, Sweden
ckDepartment of Internal Medicine I, Community Hospital Mittelrhein, Koblenz, Germany
clAssociation of Medical Practices in Hematology and Internal Oncology, Troisdorf, Germany
cmAssociation for Oncological Studies (Gefos), Dortmund, Germany
cnInstitute of Pathology, Technical University of Munich, Munich, Germany
coDivision of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany
cpGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
cqDepartment of Gastroenterology, Marienhaus Hospital Ahrweiler, Ahrweiler, Germany
crDepartment of Gastroenterology, Helios Hospital Siegburg, Siegburg, Germany
csDepartment of Gastroenterology, St. Elisabeth Hospital Bonn, Bonn, Germany
ctUnit of Oncological Gastroenterology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
cuGastroenterological Centre, Dr. Plaßmann, Bonn, Germany
cvGastroenterological Centre, Dr. Geppert, Bayreuth, Germany
cwDepartment of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany
cxDepartment of Internal Medicine II, Hospital of the Ludwig Maximilians University of Munich, Munich, Germany
cyDepartment of Surgical Oncology, Centre Hospitalier Lyon-sud, Lyon, France
cz2nd Department of General Surgery, Medical University of Lublin, Lublin, Poland
daEpidemiology Section, Public Health Division, Department of Health of Madrid, Madrid, Spain
dbGastroenterology Department, Portuguese Institute of Oncology of Porto, 4200-072 Porto, Portugal
dcResearch Department of the Portuguese League Against Cancer-North (LPCC-NRNorte), 4200-177 Porto, Portugal
ddDigestive Diseases Centre GASTRO, Riga, Latvia
∗Corresponding author. Center for Human Genetics, University Hospital of Marburg, Baldingerstraße, Marburg 35033, Germany. johannes.schumacher@uni-marburg.de
dfJointly directed the study.