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. 1980 Mar;64(3):191–200. doi: 10.1136/bjo.64.3.191

Changes in visual function and in the posterior segment of the eye during treatment of onchocerciasis with diethylcarbamazine citrate.

A C Bird, H el-Sheikh, J Anderson, H Fuglsang
PMCID: PMC1039386  PMID: 7387952

Abstract

Eighteen patients, moderately to heavily infected with onchocerciasis, were treated with a standard course of diethylcarbamazine citrate (DEC-C). In addition to the well recognised systemic reactions to treatment, the following ocular changes occurred during therapy: (1) Transient pigment epithelial lesions were detected in 7 patients by fluorescein angiography. (2) Optic disc leakage, as shown by fluorescein angiography, developed in 9 patients, and increase of pre-existing leakage was demonstrated in 3 further patients. (3) Visual field loss was documented in 5 patients. These observations have grave implications for DEC-C therapy in onchocerciasis. They emphasise the need for great caution in its use in the treatment of onchocerciasis in heavily infected patients and for close supervision of ocular function during therapy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson J., Fuglsang H. Further studies on the treatment of ocular onchocerciasis with diethylcarbamazine and suramin. Br J Ophthalmol. 1978 Jul;62(7):450–457. doi: 10.1136/bjo.62.7.450. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Anderson J., Fuglsang H. Ocular onchocerciasis. Trop Dis Bull. 1977 Apr;74(4):257–272. [PubMed] [Google Scholar]
  3. Anderson J., Fuglsang H., de C Marshall T. F. Effects of diethylcarbamazine on ocular onchocerciasis. Tropenmed Parasitol. 1976 Sep;27(3):263–278. [PubMed] [Google Scholar]
  4. Anderson J., Fuglsang H., de C Marshall T. F. Effects of suramin on ocular onchocerciasis. Tropenmed Parasitol. 1976 Sep;27(3):279–296. [PubMed] [Google Scholar]
  5. Bird A. C., Anderson J., Fuglsang H. Morphology of posterior segment lesions of the eye in patients with onchocerciasis. Br J Ophthalmol. 1976 Jan;60(1):2–20. doi: 10.1136/bjo.60.1.2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Borland R. G., Brennan D. H., Marshall J., Viveash J. P. The role of fluorescein angiography in the detection of laser-induced damage to the retina: a threshold study for Q-switched, neodymium and ruby lasers. Exp Eye Res. 1978 Oct;27(4):471–493. doi: 10.1016/0014-4835(78)90025-8. [DOI] [PubMed] [Google Scholar]
  7. Bryceson A. D., Warrell D. A., Pope H. M. Dangerous reactions to treatment of onchocerciasis with diethylcarbamazine. Br Med J. 1977 Mar 19;1(6063):742–744. doi: 10.1136/bmj.1.6063.742. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Budden F. Letter: Ocular onchocerciasis. Am J Ophthalmol. 1973 Dec;76(6):1027–1028. doi: 10.1016/0002-9394(73)90112-8. [DOI] [PubMed] [Google Scholar]
  9. Deutman A. F., Lion F. Choriocapillaris nonperfusion in acute multifocal placoid pigment epitheliopathy. Am J Ophthalmol. 1977 Nov;84(5):652–657. doi: 10.1016/0002-9394(77)90380-4. [DOI] [PubMed] [Google Scholar]
  10. Duke B. O. The effects of drugs on Onchocerca volvulus. 3. Trials of suramin at different dosages and a comparison of the brands Antrypol, Moranyl and Naganol. Bull World Health Organ. 1968;39(2):157–167. [PMC free article] [PubMed] [Google Scholar]
  11. Duke B. O., Vincelette J., Moore P. J. The populatin dynamics of Onchocerca volvulus microfilariae during treatment with suramin and diethylcarbamazine. Tropenmed Parasitol. 1976 Jun;27(2):133–144. [PubMed] [Google Scholar]
  12. Fuglsang H., Anderson J. Letter: Collapse during treatment of onchocerciasis with diethylcarbamazine. Trans R Soc Trop Med Hyg. 1974;68(1):72–73. doi: 10.1016/0035-9203(74)90259-4. [DOI] [PubMed] [Google Scholar]
  13. Fuglsang H., Anderson J. The concentration of microfilariae in the skin near the eye as a simple measure of the severity of onchocerciasis in a community and as an indicator of danger to the eye. Tropenmed Parasitol. 1977 Mar;28(1):63–67. [PubMed] [Google Scholar]
  14. Gibson D. W., Connor D. H., Brown H. L., Fuglsang H., Anderson J., Duke B. O., Buck A. A. Onchocercal dermatitis: ultrastructural studies of microfilariae and host tissues, before and after treatment with diethylcarbamazine (Hetrazan). Am J Trop Med Hyg. 1976 Jan;25(1):74–87. doi: 10.4269/ajtmh.1976.25.74. [DOI] [PubMed] [Google Scholar]
  15. Jones B. R., Anderson J., Fuglsang H. Effects of various concentrations of diethylcarbamazine citrate applied as eye drops in ocular onchocerciasis, and the possibilities of improved therapy from continuous non-pulsed delivery. Br J Ophthalmol. 1978 Jul;62(7):428–439. doi: 10.1136/bjo.62.7.428. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. MARKELL E. K., TURNER J. Cortisone and prednisone in the suppression of allergic reactions to diethylcarbamazine treatment of onchocerciasis. Am J Trop Med Hyg. 1957 May;6(3):546–552. doi: 10.4269/ajtmh.1957.6.546. [DOI] [PubMed] [Google Scholar]
  17. Paul E. V., Zimmerman L. E. Some observations on the ocular pathology of onchocerciasis. Hum Pathol. 1970 Dec;1(4):581–594. doi: 10.1016/s0046-8177(70)80058-2. [DOI] [PubMed] [Google Scholar]
  18. RODGER F. C. The pathogenesis and pathology of ocular on-chocerciasis. Part IV. The pathology. Am J Ophthalmol. 1960 Mar;49:560–594. doi: 10.1016/0002-9394(60)91658-5. [DOI] [PubMed] [Google Scholar]
  19. Thylefors B., Tønjum A. M. Visual field defects in onchocerciasis. Br J Ophthalmol. 1978 Jul;62(7):462–467. doi: 10.1136/bjo.62.7.462. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Vedy J., Sirol J. A propos d'une papillite onchocerquienne. Med Trop (Mars) 1971 Sep-Oct;31(5):559–564. [PubMed] [Google Scholar]
  21. Vedy J., Sirol J., Coulm J. La rétinopathie ponctuée albescente onchocerquienne. Note préliminaire. Bull Soc Pathol Exot Filiales. 1971 Jul-Aug;64(4):479–486. [PubMed] [Google Scholar]

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