Abstract
The presence and localisation of T and B lymphocytes in biopsy specimens of human conjunctiva and lacrimal gland from 34 patients were studied in frozen sections. Eighteen patients had follicular conjunctivitis, 13 patients had Sjögren's syndrome, and 3 were normal. All cases of follicular conjunctivitis showed a similar picture. B cells were in higher number than T cells, but both types of lymphocytes were present in the infiltrates. In the developed follicles T cells occupied the periphery and B cells the central part of the infiltrates. In patients with Sjögren's syndrome the conjunctival biopsies showed a higher number of B lymphocytes. The number of T cells was higher in the lesions from Sjögren's syndrome than in cases of follicular conjunctivitis. The infiltrate in lacrimal gland biopsies showed T cells which were scattered while B cells were more numerous and formed clusters close to vessels. Normal conjunctiva and lacrimal gland showed no adherence of either sheep erythrocytes or human erythrocytes sensitised with antibody and complement.
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- Gelfand M. C., Frank M. M., Green I. A receptor for the third component of complement in the human renal glomerulus. J Exp Med. 1975 Oct 1;142(4):1029–1034. doi: 10.1084/jem.142.4.1029. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kajdacsy-Balla A. A., Mendes N. F. Rosétte formation between human b lymphocytes and zymosan-C3 complexes using different complement sources. J Immunol Methods. 1976;9(3-4):205–209. doi: 10.1016/0022-1759(76)90195-2. [DOI] [PubMed] [Google Scholar]
- Mendes N. F. Immunological identification of human lymphoid cell populations. Lymphology. 1977 Jun;10(2):85–93. [PubMed] [Google Scholar]
- Mendes N. F., Kopersztych S., Mota N. G. T and B lymphocytes in patients with lepromatous leprosy. Clin Exp Immunol. 1974 Jan;16(1):23–29. [PMC free article] [PubMed] [Google Scholar]
- Mendes N. F., Miki S. S., Peixinho Z. F. Combined detection of human T and B lymphocytes by rosette formation with sheep erythrocytes and zymosan-C3 complexes. J Immunol. 1974 Aug;113(2):531–536. [PubMed] [Google Scholar]
- Scheinberg M. A., Mendes N. F., Kopersztych S., Cathcart E. S. Clinical applications of T, B, and K cell determinations in rheumatic diseases: a review. Semin Arthritis Rheum. 1976 Aug;6(1):1–18. doi: 10.1016/s0049-0172(76)80002-9. [DOI] [PubMed] [Google Scholar]
- Silveira N. P., Mendes N. F., Tolnai M. E. Tissue localization of two populations of human lymphocytes distinguished by membrane receptors. J Immunol. 1972 May;108(5):1456–1460. [PubMed] [Google Scholar]