Abstract
Serum copper, ceruloplasmin, and urinary copper were estimated in 13 normal subjects and 24 patients with primary retinitis pigmentosa. The serum copper levels in patients appeared to be higher and ceruloplasmin levels lower than in the normal subjects. The patients seem to fall into 2 categories with regard to urinary copper. About a third of them excreted 2-4 times more copper in the urine, while in the others the excretion is comparable to normal subjects. It appears possible that there exists in India a genetic isolate of retinitis pigmentosa with altered copper metabolism. The distribution of these patients may be different between the northern and southern parts of the country.
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Selected References
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- Ehlers N., Bülow N. Clinical copper metabolism parameters in patients with retinitis pigmentosa and other tapeto-retinal degenerations. Br J Ophthalmol. 1977 Sep;61(9):595–596. doi: 10.1136/bjo.61.9.595. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GIORGIO A. J., CARTWRIGHT G. E., WINTROBE M. M. DETERMINATION OF URINARY COPPER BY MEANS OF DIRECT EXTRACTION WITH ZINC DIBENZYL DITHIOCARBAMATE. Am J Clin Pathol. 1964 Jan;41:22–26. doi: 10.1093/ajcp/41.1.22. [DOI] [PubMed] [Google Scholar]
- Gahlot D. K., Khosla P. K., Makashir P. D., Vasuki K., Basu N. Copper metabolism in retinitis pigmentosa. Br J Ophthalmol. 1976 Nov;60(11):770–774. doi: 10.1136/bjo.60.11.770. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gouras P., Chader G. Editorials on recent advances: Retinitis pigmentosa and retinol-binding protein. Invest Ophthalmol. 1974 Apr;13(4):239–242. [PubMed] [Google Scholar]
- Lewis K. O. The nature and excretion of biliary copper in man. Clin Sci. 1973 Jul;45(1):133–134. [PubMed] [Google Scholar]
- Lewis K. O. The nature and excretion of biliary copper in man. Clin Sci. 1973 Jul;45(1):133–134. [PubMed] [Google Scholar]
- Marmor M. F., Nelson J. W., Levin A. S. Copper metabolism in American retinitis pigmentosa patients. Br J Ophthalmol. 1978 Mar;62(3):168–171. doi: 10.1136/bjo.62.3.168. [DOI] [PMC free article] [PubMed] [Google Scholar]